PMID- 30106214
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Linking)
VI  - 29
IP  - 11
DP  - 2018 Nov
TI  - Cessation of pacing in super-responders of cardiac resynchronization therapy: A 
      randomized controlled trial.
PG  - 1548-1555
LID - 10.1111/jce.13711 [doi]
AB  - BACKGROUND: The consequence of cessation of biventricular pacing in 
      super-responders of cardiac resynchronization therapy (CRT) has not been fully 
      investigated. METHODS: In this prospective, single-blinded clinical trial, 21 
      super-responders were randomly assigned to the ceased pacing (CeP, 11 patients) 
      group or the continued pacing (CoP, 10 patients) group. Patients randomized to 
      the CeP group underwent cessation of biventricular pacing. New York Heart 
      Association (NYHA) class, quality of life (QOL) assessed with Minnesota 
      questionnaire, 6-minute walking distance (6MWD), left ventricular end systolic 
      volume (LVESV), left ventricular end-diastolic volume (LVEDV), and left 
      ventricular ejection fraction (LVEF) were compared between groups at 3- and 
      6-month follow-up. RESULTS: No significant difference was observed between the 
      CeP and CoP groups regarding NYHA class, QOL, 6MWD, LVESV, LVEDV, or LVEF after 3 
      months (all P > 0.05). After 6 months, there existed no significant difference 
      between the CeP and CoP groups with regard to NYHA class, QOL, 6MWD, LVESV, and 
      LVEDV (all P > 0.05); however, LVEF was significantly lower in the CeP group than 
      that of the CoP group (0.49 +/- 0.10 vs 0.60 +/- 0.11, P = 0.04), and LVEF was 
      significantly reduced in the CeP group compared with the baseline value at 
      randomization (0.49 +/- 0.10 vs 0.54 +/- 0.06, P = 0.04). CONCLUSION: LVEF was 
      significantly reduced in super-responders of CRT 6 months after cessation of 
      pacing. Super-responders to CRT should receive continued, long-term pacing to 
      preserve recovered LV function.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Liang, Yixiu
AU  - Liang Y
AUID- ORCID: 0000-0001-5467-8958
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Wang, Qingqing
AU  - Wang Q
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Zhang, Mingliang
AU  - Zhang M
AD  - Department of Cardiology, Central Hospital of Tai'an, Shandong, China.
FAU - Wang, Jingfeng
AU  - Wang J
AUID- ORCID: 0000-0002-6397-2988
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Chen, Haiyan
AU  - Chen H
AD  - Department of Echocardiography, Shanghai Institute of Medical Imaging, Zhongshan 
      Hospital, Fudan University, Shanghai, China.
FAU - Yu, Ziqing
AU  - Yu Z
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Gong, Xue
AU  - Gong X
AD  - Department of Cardiology, Deltahealth Hospital, Shanghai, China.
FAU - Su, Yangang
AU  - Su Y
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Ge, Junbo
AU  - Ge J
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180925
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
MH  - Aged
MH  - Cardiac Resynchronization Therapy/methods/*trends
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Single-Blind Method
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*physiopathology/*therapy
MH  - Ventricular Function, Left/*physiology
MH  - Withholding Treatment/*trends
OTO - NOTNLM
OT  - cardiac resynchronization therapy (CRT)
OT  - heart failure
OT  - super-responder
EDAT- 2018/08/15 06:00
MHDA- 2019/11/05 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/02/21 00:00 [received]
PHST- 2018/08/03 00:00 [revised]
PHST- 2018/08/06 00:00 [accepted]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/08/15 06:00 [entrez]
AID - 10.1111/jce.13711 [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2018 Nov;29(11):1548-1555. doi: 10.1111/jce.13711. 
      Epub 2018 Sep 25.