PMID- 30106244
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20220410
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Print)
IS  - 1045-3873 (Linking)
VI  - 29
IP  - 11
DP  - 2018 Nov
TI  - Acute noncontrast T1-weighted magnetic resonance imaging predicts chronic 
      radiofrequency ablation lesions.
PG  - 1556-1562
LID - 10.1111/jce.13709 [doi]
AB  - BACKGROUND: Magnetic resonance imaging (MRI) has been used to visualize 
      radiofrequency (RF) ablation lesions but the relationship between volumes that 
      enhance in acute MRI and the chronic lesion size is unknown. OBJECTIVES: The main 
      goal was to use noncontrast (native) T1-weighted (T1w) MRI and late gadolinium 
      enhancement (LGE)-MRI to visualize lesions acutely and chronically and correlate 
      the acute area of enhancement with chronic lesion size in histology. MATERIALS 
      AND METHODS: In a canine (n = 9) model RF ablation lesions were created in both 
      ventricles. Native T1w MRI and LGE-MRI were acquired acutely after the ablation 
      procedure. After 8 weeks, another set of RF ablations was performed, and the MRI 
      study was repeated. Volume and depth of enhancement in native T1w MRI and LGE-MRI 
      acquired after the initial ablation procedure were correlated with chronic lesion 
      volume and depth in histology. RESULTS: Thirty-three lesions were analyzed. 
      Native T1w MRI visualized the acute lesions but not the chronic lesions. LGE-MRI 
      showed both acute and chronic lesions. Acute native T1w MRI volume (average of 
      102.1 +/- 48.5 mm(3) ) and depth (4.9 +/- 1.2 mm) correlated well with chronic 
      histological volume (105.9 +/- 51.8 mm(3) ) and depth (4.8 +/- 1.3 mm) with R(2) of 
      0.881 (P < 0.001) and 0.874 (P < 0.001), respectively. Acute LGE-MRI had a 
      significantly higher volume of enhancement of 499.7 +/- 214.4 mm(3) (P < 0.001) and 
      depth of 7.5 +/- 1.8 mm ( P < 0.001) when compared with chronic histological lesion 
      volume and depth. CONCLUSIONS: Native T1w MRI acquired acutely after RF ablation 
      is a good predictor of chronic lesion size. Acute LGE-MRI significantly 
      overestimates the chronic lesion size.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Kholmovski, Eugene G
AU  - Kholmovski EG
AUID- ORCID: 0000-0002-3271-7247
AD  - Division of Cardiovascular Medicine, CARMA Center, University of Utah, Salt Lake 
      City, Utah.
AD  - Department of Radiology and Imaging Sciences, UCAIR, University of Utah, Salt 
      Lake City, Utah.
FAU - Silvernagel, Josh
AU  - Silvernagel J
AD  - Department of Bioengineering, University of Utah, Salt Lake City, Utah.
AD  - Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
FAU - Angel, Nathan
AU  - Angel N
AD  - Department of Bioengineering, University of Utah, Salt Lake City, Utah.
AD  - Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
FAU - Vijayakumar, Sathya
AU  - Vijayakumar S
AD  - Division of Cardiovascular Medicine, CARMA Center, University of Utah, Salt Lake 
      City, Utah.
AD  - Department of Radiology and Imaging Sciences, UCAIR, University of Utah, Salt 
      Lake City, Utah.
FAU - Thomas, Samuel
AU  - Thomas S
AD  - Department of Medicine, School of Medicine, University of Utah, Salt Lake City, 
      Utah.
FAU - Dosdall, Derek
AU  - Dosdall D
AD  - Department of Bioengineering, University of Utah, Salt Lake City, Utah.
AD  - Department of Surgery, University of Utah, Salt Lake City, Utah.
AD  - Nora Eccles Harrison Cardiovascular Research and Training Institute, University 
      of Utah, Salt Lake City, Utah.
FAU - MacLeod, Rob
AU  - MacLeod R
AD  - Department of Bioengineering, University of Utah, Salt Lake City, Utah.
AD  - Nora Eccles Harrison Cardiovascular Research and Training Institute, University 
      of Utah, Salt Lake City, Utah.
FAU - Marrouche, Nassir F
AU  - Marrouche NF
AD  - Division of Cardiovascular Medicine, CARMA Center, University of Utah, Salt Lake 
      City, Utah.
AD  - Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
FAU - Ranjan, Ravi
AU  - Ranjan R
AUID- ORCID: 0000-0002-3321-2435
AD  - Department of Bioengineering, University of Utah, Salt Lake City, Utah.
AD  - Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
AD  - Nora Eccles Harrison Cardiovascular Research and Training Institute, University 
      of Utah, Salt Lake City, Utah.
LA  - eng
GR  - K23 HL115084/HL/NHLBI NIH HHS/United States
GR  - P41 GM103545/GM/NIGMS NIH HHS/United States
GR  - R01 HL128752/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180925
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
MH  - Animals
MH  - Dogs
MH  - Heart Diseases/*diagnostic imaging/*surgery
MH  - Magnetic Resonance Imaging/*methods
MH  - Predictive Value of Tests
MH  - Radiofrequency Ablation/*methods
PMC - PMC6235745
MID - NIHMS988962
OTO - NOTNLM
OT  - LGE-MRI
OT  - cardiac magnetic resonance image
OT  - catheter ablation
OT  - lesion visualization
OT  - noncontrast MRI
COIS- Eugene Kholmovski reports equity interest in Marrek Inc; consultant to Marrek 
      Inc.
EDAT- 2018/08/15 06:00
MHDA- 2019/11/05 06:00
PMCR- 2018/11/15
CRDT- 2018/08/15 06:00
PHST- 2018/04/06 00:00 [received]
PHST- 2018/07/30 00:00 [revised]
PHST- 2018/08/03 00:00 [accepted]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/08/15 06:00 [entrez]
PHST- 2018/11/15 00:00 [pmc-release]
AID - 10.1111/jce.13709 [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2018 Nov;29(11):1556-1562. doi: 10.1111/jce.13709. 
      Epub 2018 Sep 25.