PMID- 30106666
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 36
IP  - 2
DP  - 2019 Jan 15
TI  - Expression of Autophagy Signaling Molecules in the Outer Membranes of Chronic 
      Subdural Hematomas.
PG  - 403-407
LID - 10.1089/neu.2018.5626 [doi]
AB  - Chronic subdural hematoma (CSDH) is fundamentally treatable, although it 
      sometimes recurs. We observed, however, several cases of spontaneous resolution 
      of CSDH outer membranes, even in a trabecular type of CSDH, after a trepanation 
      surgical procedure. In this study, we examined the expression of molecules of the 
      autophagy signaling pathway in CSDH outer membranes. Eight patients whose outer 
      membranes were obtained successfully during trepanation were included in this 
      study. By Western blot analysis, we examined the expression of mammalian target 
      of rapamycin (mTOR); GbetaL; UNC-51-like kinase-1 (ULK1); Beclin-1; 
      autophagy-related genes (Atg) 3, 5, 7, 12, 13, and 16L1beta,alpha; the autophagy marker 
      Light Chain3A/B (LC3A/B); and beta-actin, which constitute the autophagy signaling 
      pathway. The expression levels of Beclin-1, Atg12, and LC3A/B were also examined 
      by immunohistochemistry. Almost all of these molecules could be detected in all 
      samples. Beclin-1, Atg12, and LC3A/B were found to be localized in the 
      endothelial cells of vessels and fibroblasts in CSDH. We detected molecules of 
      the autophagy signaling pathway in CSDH outer membranes. Autophagy contributes to 
      the tissue homeostatic process, maintaining cellular integrity by clearing 
      debris. Our data suggest that autophagy might play an important role in the 
      spontaneous resolution of CSDH. Therefore, these molecules may be novel 
      therapeutic targets for the treatment of those with CSDH.
FAU - Osuka, Koji
AU  - Osuka K
AD  - 1 Department of Neurological Surgery, Aichi Medical University Aichi, Japan.
FAU - Watanabe, Yasuo
AU  - Watanabe Y
AD  - 2 High Technology Research Center, Pharmacology, Showa Pharmaceutical University, 
      Tokyo, Japan.
FAU - Usuda, Nobuteru
AU  - Usuda N
AD  - 3 Department of Anatomy II, Fujita Health University School of Medicine, Aichi, 
      Japan.
FAU - Aoyama, Masahiro
AU  - Aoyama M
AD  - 1 Department of Neurological Surgery, Aichi Medical University Aichi, Japan.
FAU - Takeuchi, Mikinobu
AU  - Takeuchi M
AD  - 1 Department of Neurological Surgery, Aichi Medical University Aichi, Japan.
FAU - Takayasu, Masakazu
AU  - Takayasu M
AD  - 1 Department of Neurological Surgery, Aichi Medical University Aichi, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180814
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Autophagy/*physiology
MH  - Female
MH  - Hematoma, Subdural, Chronic/*metabolism
MH  - Humans
MH  - Male
MH  - Remission, Spontaneous
MH  - Signal Transduction/physiology
MH  - Trephining
OTO - NOTNLM
OT  - autophagy
OT  - chronic subdural hematoma
OT  - spontaneous resolution
EDAT- 2018/08/15 06:00
MHDA- 2020/03/31 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2018/08/15 06:00 [entrez]
AID - 10.1089/neu.2018.5626 [doi]
PST - ppublish
SO  - J Neurotrauma. 2019 Jan 15;36(2):403-407. doi: 10.1089/neu.2018.5626. Epub 2018 
      Aug 14.