PMID- 30107135
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191023
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 44
IP  - 3
DP  - 2019 Mar
TI  - High-fat diet leads to adiposity and adipose tissue inflammation: the effect of 
      whey protein supplementation and aerobic exercise training.
PG  - 255-262
LID - 10.1139/apnm-2018-0307 [doi]
AB  - There is little understanding about dietary proteins and their potential 
      contribution to obesity-induced inflammation. This study investigates the effect 
      of 10 weeks of aerobic training and whey protein (WP) supplementation on visceral 
      adipose tissue inflammation in rats fed a high-fat diet (HFD). In the first 
      phase, which lasted 9 weeks, 40 male Wistar rats were randomly divided into 2 
      groups: (1) normal diet (n = 8), and (2) HFD (n = 32). In the second phase, rats 
      fed an HFD were randomly assigned into 4 groups (n = 8/group): (1) sedentary, (2) 
      WP, (3) aerobic training, and (4) WP + aerobic training. The aerobic training was 
      performed for 10 weeks, 5 days/week at 21 m/min, 15% incline, for 60 min/day. HFD 
      significantly increased body weight, adiposity index, fat pads weight, glucose 
      levels, and insulin resistance index compared with the normal diet. Also, levels 
      of tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein-1 
      (MCP-1), hypoxia inducible factor 1 alpha (HIF-1alpha), and vascular endothelial 
      growth factor A (VEGF-A) in adipose tissue and serum levels of TNF-alpha were 
      increased in the HFD group. Glucose levels, insulin resistance index, and 
      triglycerides were reduced only by WP, independently of aerobic training. Both 
      the aerobic training and WP reduced the fat pads weight and levels of TNF-alpha, 
      HIF-1alpha, and VEGF-A in adipose tissue. Nevertheless, the levels of MCP-1 in 
      adipose tissue and serum levels of TNF-alpha and MCP-1 were not reduced significantly 
      by WP or aerobic training. These findings suggest that both aerobic training and 
      WP supplementation lead to a reduction in adiposity and ameliorate 
      obesity-induced inflammation in visceral adipose tissue.
FAU - Ahmadi-Kani Golzar, Farhad
AU  - Ahmadi-Kani Golzar F
AD  - a Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, 
      Iran.
FAU - Fathi, Rozita
AU  - Fathi R
AD  - a Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, 
      Iran.
FAU - Mahjoub, Soleiman
AU  - Mahjoub S
AD  - b Cellular and Molecular Biology Research Center, Health Research Institute, 
      Babol University of Medical Science, Babol, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180814
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Hif1a protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Whey Proteins)
RN  - 0 (vascular endothelial growth factor A, rat)
SB  - IM
MH  - Adiposity
MH  - Animals
MH  - Body Weight
MH  - Chemokine CCL2/metabolism
MH  - Diet, High-Fat
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Inflammation/*physiopathology
MH  - Insulin Resistance
MH  - Intra-Abdominal Fat/metabolism/*physiopathology
MH  - Male
MH  - *Physical Conditioning, Animal
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Whey Proteins/*administration & dosage
OTO - NOTNLM
OT  - alimentation riche en gras
OT  - entrainement physique
OT  - exercise training
OT  - high-fat diet
OT  - hypoxia
OT  - hypoxie
OT  - inflammation
OT  - proteine de lactoserum
OT  - whey protein
EDAT- 2018/08/15 06:00
MHDA- 2019/10/24 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2018/08/15 06:00 [entrez]
AID - 10.1139/apnm-2018-0307 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2019 Mar;44(3):255-262. doi: 10.1139/apnm-2018-0307. 
      Epub 2018 Aug 14.