PMID- 30107337
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 171
DP  - 2018 Nov 1
TI  - Angiopep-2 modified PEGylated 2-methoxyestradiol micelles to treat the PC12 cells 
      with oxygen-glucose deprivation/reoxygenation.
PG  - 638-646
LID - S0927-7765(18)30533-2 [pii]
LID - 10.1016/j.colsurfb.2018.08.009 [doi]
AB  - 2-Methoxyestradiol (2ME2), as a microtubule and hypoxia-inducible factor-1 
      (HIF-1) inhibitor, can be used to treat cerebral ischemia-reperfusion (I/R) 
      injury. However, its poor water solubility compromises its efficacy as a 
      neuroprotectant. Herein, we synthesized PEGylated 2ME2 and angiopep-2 capped 
      PEGylated 2ME2 and fabricated angiopep-2 modified PEGylated 2ME2 micelles 
      containing free 2ME2 (ANG-PEG-2ME2/2ME2) via emulsion-solvent evaporation method. 
      The effect of the micelles on ischemia-reoxygenation injury was evaluated by 
      oxygen-glucose deprivation/reoxygenation (OGD/R) models with different degrees of 
      PC12 cell damage. In comparison with free 2ME2, the micelles significantly 
      increased the cell viability, inhibited reactive oxygen species (ROS) generation 
      and apoptosis for PC12 cells with 0.5 and 4 h OGD followed by 24 h reoxygenation. 
      Taken together, the angiopep-2 modified 2ME2-loaded micelles could effectively 
      reduce the injury of PC12 cells induced by OGD/R.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hu, Lijun
AU  - Hu L
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China.
FAU - Wang, Yun
AU  - Wang Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China.
FAU - Zhang, Yihui
AU  - Zhang Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China.
FAU - Yang, Ning
AU  - Yang N
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China.
FAU - Han, Huijie
AU  - Han H
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China.
FAU - Shen, Yuanyuan
AU  - Shen Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China. Electronic address: shenyuanyuan@sjtu.edu.cn.
FAU - Cui, Derong
AU  - Cui D
AD  - Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to 
      Shanghai Jiao Tong University, Shanghai 200233, China. Electronic address: 
      cuishuning118@163.com.
FAU - Guo, Shengrong
AU  - Guo S
AD  - School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, China. Electronic address: srguo@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180808
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Angiopep-2)
RN  - 0 (Micelles)
RN  - 0 (Peptides)
RN  - 0 (Reactive Oxygen Species)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 6I2QW73SR5 (2-Methoxyestradiol)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - 2-Methoxyestradiol/chemical synthesis/chemistry/*pharmacology
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Cell Survival/drug effects
MH  - Glucose/*chemistry/metabolism
MH  - Micelles
MH  - Oxidation-Reduction
MH  - Oxygen/*chemistry/metabolism
MH  - PC12 Cells
MH  - Particle Size
MH  - Peptides/*chemistry
MH  - Polyethylene Glycols/*chemistry
MH  - Rats
MH  - Reactive Oxygen Species/antagonists & inhibitors/metabolism
MH  - Surface Properties
OTO - NOTNLM
OT  - OGD/R
OT  - PC12 cells
OT  - PEGylated 2-methoxyestradiol micelles
EDAT- 2018/08/15 06:00
MHDA- 2019/01/08 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/05/16 00:00 [received]
PHST- 2018/08/04 00:00 [revised]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/08/15 06:00 [entrez]
AID - S0927-7765(18)30533-2 [pii]
AID - 10.1016/j.colsurfb.2018.08.009 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2018 Nov 1;171:638-646. doi: 
      10.1016/j.colsurfb.2018.08.009. Epub 2018 Aug 8.