PMID- 30107667
OWN - NLM
STAT- MEDLINE
DCOM- 20181003
LR  - 20190318
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 8
DP  - 2018 Aug 8
TI  - [Angiofibroma of soft tissue: a clinicopathologic analysis of 24 cases].
PG  - 616-621
LID - 10.3760/cma.j.issn.0529-5807.2018.08.009 [doi]
AB  - Objective: To investigate the clinicopathologic and genetic features, pathologic 
      diagnosis and differential diagnosis of angiofibroma of soft tissue(AFST). 
      Methods: The clinicopathologic characteristics of 24 cases diagnosed at Fudan 
      University Shanghai Cancer Center from 2011 to 2017 were analyzed; 
      immunohistochemical staining and interphase fluorescence in situ hybridization 
      (FISH) were performed, and the literatures were also reviewed. Results: There 
      were 15 male and 9 female (maleratiofemale=1.7ratio1.0) patients with age of onset 
      ranging from 8 to 68 years (mean, 45 years). Fourteen cases occurred in 
      extremities, including upper limbs (n=3) and lower limbs (n=11); seven cases were 
      in the trunk, and 1 case each was in the temporal region, retroperitoneum and 
      liver, respectively. Clinically, the tumors usually presented as a slowly growing 
      painless mass. Tumor sizes ranged from 0.8 to 14 cm (mean 4.6 cm). 
      Microscopically, most lesions were well-circumscribed, with fibrous capsules. Few 
      cases infiltrated the surrounding fibrofatty tissue focally. The tumors were 
      mainly composed of sparse short spindle cells and numerous small, branching, 
      thin-walled blood vessels distributed in amyxoid, fibromyxoid or collagenous 
      matrix, often accompanied by medium-sized, round or irregular and ecstatic 
      vessels at the tumor periphery.By immunohistochemistry, all tested cases 
      expressed vimentin (5/5), and showed variable positivity for EMA (2/4), ER (1/2), 
      PR (2/3), alpha-SMA (1/18)and desmin (1/10). Ki-67 proliferation index were all less 
      than 5%. CD34, CD31 and ERG staining clearly outlined the contours of blood 
      vessels in the stroma. Four cases were tested for NCOA2 gene rearrangement by 
      FISH, of which three were positive. Follow-up data was available in 17 patients 
      (range, 3 to 69 months; mean, 30 months) were all free of disease. Conclusions: 
      Soft tissue angiofibroma is a benign fibroblastic neoplasm characterized by a 
      prominent and complex vasculature set in a myxoid-to-collagenous stroma, and 
      cytogenetically a distinctive NCOA2 gene rearrangement. Caution should be 
      exercised for the possibility of potentially misinterpretation of AFST as 
      vascular tumors and other myxoid soft tissue tumors.
FAU - Xu, X L
AU  - Xu XL
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Liu, J G
AU  - Liu JG
AD  - Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University and 
      Shanghai Respiratory Research Institute, Shanghai 200032, China.
FAU - Sun, M
AU  - Sun M
FAU - Yu, L
AU  - Yu L
FAU - Liu, Q Y
AU  - Liu QY
FAU - Bai, Q M
AU  - Bai QM
FAU - Wu, L J
AU  - Wu LJ
FAU - Wang, J
AU  - Wang J
LA  - chi
GR  - 81202083/National Natural Science Foundation of China-Youth Foundation/
GR  - 15ZR1407500/Shanghai Municipal Natural Science Foundation/
GR  - 2015ZB0201/Shanghai Key Developing Disciplines/
GR  - HDC12014105/Shanghai Hospital Development Center Emerging Advanced Technology 
      Joint Research Project/
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (ACTA2 protein, human)
RN  - 0 (Actins)
RN  - 0 (Desmin)
RN  - 0 (NCOA2 protein, human)
RN  - 0 (Nuclear Receptor Coactivator 2)
RN  - 0 (Vimentin)
SB  - IM
MH  - Actins/analysis
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Angiofibroma/blood supply/chemistry/genetics/pathology
MH  - Child
MH  - China
MH  - Desmin/analysis
MH  - Diagnosis, Differential
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mitotic Index
MH  - Neoplasms, Fibrous Tissue
MH  - Nuclear Receptor Coactivator 2/genetics
MH  - *Soft Tissue Neoplasms/blood supply/genetics/pathology
MH  - Tumor Burden
MH  - Vimentin/analysis
MH  - Young Adult
OTO - NOTNLM
OT  - Angiofibroma
OT  - Diagnosis, differential
OT  - Immunohistochemistry
OT  - In situ hybridization, fluorescence
EDAT- 2018/08/16 06:00
MHDA- 2018/10/04 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/08/15 06:00 [entrez]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2018/10/04 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2018.08.009 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Aug 8;47(8):616-621. doi: 
      10.3760/cma.j.issn.0529-5807.2018.08.009.