PMID- 30108451
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 25
IP  - 5
DP  - 2018 Jul
TI  - MicroRNA-4728 serves as a suppressor and antagonist of oncogenic MAPK in Burkitt 
      lymphoma.
PG  - 982-985
LID - 10.1016/j.sjbs.2018.05.010 [doi]
AB  - OBJECTIVE: This study identified the biological role of miR-4728 in Burkitt 
      lymphoma (BL) process. METHODS: Ramos cells were used to analyze MicroRNA-4728 
      (miR-4728) biological functions. MiR-4728 expression was investigated in 14 
      randomly chosen tumor tissues and 12 noncancerous tissues by qRT-PCR. Cyquant 
      assay was used to monitor cell proliferation. Colony formation assay was 
      performed to study the effectiveness of miR-4728 on the proliferation of cells. 
      The effects of miR-4728 on MAPK signaling pathway were detected by luciferase 
      reporter assay. The significance of differences between groups were evaluated by 
      SPSS. RESULTS: In this study, MiRNA-4728 was observed to down-regulated in BL 
      tissues compared to the noncancerous tissues. Additionally, miR-4728 inhibited 
      Ramos cell proliferation. Moreover, miR-4728 overexpression also decreased the 
      MAPK signaling activity. CONCLUSION: Our results suggested that miR-4728 serves 
      as a suppressor and antagonist of oncogenic MAPK in Burkitt lymphoma. The 
      appropriate regulation of miR-4728 might be vital to improve BL treatment.
FAU - Wang, Wei
AU  - Wang W
AD  - Baoding First Central Hospital, Baoding 071000, PR China.
FAU - Lin, Peng
AU  - Lin P
AD  - Baoding First Central Hospital, Baoding 071000, PR China.
FAU - Yao, Haiying
AU  - Yao H
AD  - Baoding First Central Hospital, Baoding 071000, PR China.
FAU - Jia, Xi
AU  - Jia X
AD  - Baoding First Central Hospital, Baoding 071000, PR China.
FAU - Sun, Jirui
AU  - Sun J
AD  - Baoding First Central Hospital, Baoding 071000, PR China.
FAU - Feng, Lin
AU  - Feng L
AD  - Pavlovian Medical College, St. Petersburg 190121, Russia.
LA  - eng
PT  - Journal Article
DEP - 20180507
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC6088107
OTO - NOTNLM
OT  - Burkitt lymphoma
OT  - MAPK
OT  - miR-4728
EDAT- 2018/08/16 06:00
MHDA- 2018/08/16 06:01
PMCR- 2018/05/07
CRDT- 2018/08/16 06:00
PHST- 2018/03/29 00:00 [received]
PHST- 2018/05/04 00:00 [revised]
PHST- 2018/05/06 00:00 [accepted]
PHST- 2018/08/16 06:00 [entrez]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2018/08/16 06:01 [medline]
PHST- 2018/05/07 00:00 [pmc-release]
AID - S1319-562X(18)30121-9 [pii]
AID - 10.1016/j.sjbs.2018.05.010 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2018 Jul;25(5):982-985. doi: 10.1016/j.sjbs.2018.05.010. Epub 
      2018 May 7.