PMID- 30109559
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20221207
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 50
IP  - 12
DP  - 2018 Dec
TI  - Association between MCP-1 2518 A>G gene polymorphism and chronic kidney disease.
PG  - 2245-2253
LID - 10.1007/s11255-018-1955-1 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is involved in the pathogenesis of 
      chronic kidney diseases (CKD). MCP-1 2518 A>G gene polymorphism is associated 
      with MCP-1 status. We performed a meta-analysis to assess the association between 
      MCP-1 2518 A>G gene polymorphism and CKD risk. The eligible studies regarding the 
      relationship between MCP-1 2518 A>G gene polymorphism and CKD risk were searched 
      through electronic databases. The pooled odds ratios (ORs) and its 95% confidence 
      intervals (CIs) were calculated by using a fixed-effects model, or in the 
      presence of heterogeneity, a random-effects model. A total of 2415 cases and 2011 
      controls were recruited in our investigation. A allele/GG genotype was not 
      associated with CKD risk in overall populations, Asians, Caucasians, and 
      Africans. AA/AG genotype was not associated with the risk of CKD in overall 
      populations, Asians, Caucasians, and Africans. AA genotype was associated with a 
      lower risk of CKD in Caucasians (OR 0.816, 95% CI 0.703-0.947). AG genotype was 
      associated with a higher risk of CKD in Caucasians (OR 1.230, 95% CI 
      1.042-1.452). There was no marked publication bias. In conclusion, AA genotype 
      may be a protective factor against CKD susceptibility in Caucasians. AG genotype 
      may be a risk factor for CKD risk in Caucasians. However, more studies are needed 
      in the future.
FAU - Mao, Song
AU  - Mao S
AD  - Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai, China. edjh123456@sina.com.
FAU - Wu, Liangxia
AU  - Wu L
AD  - Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai, China. wlxmed@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20180814
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Black People/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Renal Insufficiency, Chronic/*genetics
MH  - White People/*genetics
OTO - NOTNLM
OT  - Chronic kidney diseases
OT  - Gene polymorphism
OT  - MCP-1 2518 A>G
EDAT- 2018/08/16 06:00
MHDA- 2019/04/09 06:00
CRDT- 2018/08/16 06:00
PHST- 2018/01/23 00:00 [received]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/08/16 06:00 [entrez]
AID - 10.1007/s11255-018-1955-1 [pii]
AID - 10.1007/s11255-018-1955-1 [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2018 Dec;50(12):2245-2253. doi: 10.1007/s11255-018-1955-1. Epub 
      2018 Aug 14.