PMID- 30109670 OWN - NLM STAT- MEDLINE DCOM- 20191021 LR - 20211214 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 28 IP - 12 DP - 2018 Dec TI - Comparison of Great Curvature Plication with Duodenal-Jejunal Bypass (GCP-DJB) and Sleeve Gastrectomy (SG) on Metabolic Indices and Gut Hormones in Type 2 Diabetes Mellitus Rats. PG - 4014-4021 LID - 10.1007/s11695-018-3459-6 [doi] AB - OBJECTIVE: The present study compared the therapeutic effects of great curvature plication with duodenal-jejunal bypass (GCP-DJB) and the commonly used sleeve gastrectomy (SG) in rats with type 2 diabetes mellitus (T2DM). METHODS: The rats were randomly divided into three groups: Control group (n = 6), SG group (n = 6), and GCP-DJB group (n = 6). Body weight, daily food intake, fasting blood glucose level, fasting insulin level, insulin resistance index, and fasting serum concentrations of glucagon-like peptide-1 (GLP-1), peptide tyrosine tyrosine (PYY), and bile acid were measured. In addition, postoperative changes in body weight and daily food intake at 2, 4, 6, 8, 10, and 12 weeks were also recorded. At week 12, an oral glucose tolerance test (OGTT) and insulin release test were performed to determine glucose tolerance. The insulin resistance index (IRI) was also measured. The postprandial secretion curves and area under the curve (AUC) of GLP-1, gastric inhibitory polypeptide (GIP), PYY, and bile acid were also calculated. RESULTS: Before surgery, no significant differences in body weight, daily food intake, fasting blood glucose, fasting insulin, insulin resistance index, fasting GLP-1, PYY, and bile acid were found among the three groups (P > 0.05). At postoperative week 12, body weight and food intake in the SG and GCP-DJB groups were lower than those in the Control group (P < 0.05), and body weight in the GCP-DJB group was lowest (P < 0.05). Glucose tolerance, postprandial serum insulin (INS), GLP-1, PYY, and bile acid were significantly higher in the SG and GCP-DJB groups than in the Control group (P < 0.05). The parameters related to glucose metabolism in the GCP-DJB group were higher than those in the SG group with the exception of serum insulin (P < 0.05). In addition, IRI and GIP secretion were significantly lower in the SG and GCP-DJB groups than in the Control group (P < 0.05) and were lowest in the GCP-DJB group (P < 0.05). CONCLUSION: Both GCP-DJB and SG are surgical options for the treatment of T2DM. The underlying mechanism of these treatments may be related to the decrease in body weight, food intake, GIP, IRI, and the increase in INS, GLP-1, PYY, and bile acid. According to the various metabolic indicators related to the hypoglycemic effects in T2DM, GCP-DJB was superior to SG. FAU - Qiu, Nian-Cun AU - Qiu NC AUID- ORCID: 0000-0001-6492-0744 AD - Department of General Surgery, Hainan Branch of Chinese PLA General Hospital, Sanya, 572000, China. AD - Department of General Surgery, Chang Zheng Hospital affiliated to Second Military Medical University, Shanghai, 200003, China. FAU - Li, Wei AU - Li W AD - Department of General Surgery, Chang Zheng Hospital affiliated to Second Military Medical University, Shanghai, 200003, China. FAU - Liu, Miao-E AU - Liu ME AD - Key Laboratory of Reproductive Genetics, Women's Hospital, Zhejiang University, Zhejiang, 310000, China. FAU - Cen, Xiao-Xia AU - Cen XX AD - Department of General Surgery, Chang Zheng Hospital affiliated to Second Military Medical University, Shanghai, 200003, China. FAU - Shan, Cheng-Xiang AU - Shan CX AD - Department of General Surgery, Chang Zheng Hospital affiliated to Second Military Medical University, Shanghai, 200003, China. FAU - Zhang, Wei AU - Zhang W AD - Department of General Surgery, Chang Zheng Hospital affiliated to Second Military Medical University, Shanghai, 200003, China. FAU - Liu, Qing AU - Liu Q AD - Department of General Surgery, Hainan Branch of Chinese PLA General Hospital, Sanya, 572000, China. FAU - Wang, Yang AU - Wang Y AD - Department of Hepatobiliary and Pancreatic Surgical Oncology, Chinese PLA General Hospital, Beijing, 100000, China. AD - , Beijing, China. FAU - Zhu, Ya-Ting AU - Zhu YT AD - Department of General Surgery, Hainan Branch of Chinese PLA General Hospital, Sanya, 572000, China. AD - , Beijing, China. FAU - Qiu, Ming AU - Qiu M AD - Department of General Surgery, Chang Zheng Hospital affiliated to Second Military Medical University, Shanghai, 200003, China. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 RN - 0 (Biomarkers) RN - 0 (Gastrointestinal Hormones) SB - IM MH - Animals MH - Bariatric Surgery/*methods MH - Biomarkers/blood MH - Diabetes Mellitus, Type 2/blood/diagnosis/*surgery MH - Duodenum/*surgery MH - Gastrectomy/methods MH - Gastrointestinal Hormones/*blood MH - Jejunum/*surgery MH - Male MH - Random Allocation MH - Rats MH - Rats, Sprague-Dawley MH - Treatment Outcome OTO - NOTNLM OT - Metabolic surgery OT - Therapeutic effects OT - Type 2 diabetes mellitus EDAT- 2018/08/16 06:00 MHDA- 2019/10/23 06:00 CRDT- 2018/08/16 06:00 PHST- 2018/08/16 06:00 [pubmed] PHST- 2019/10/23 06:00 [medline] PHST- 2018/08/16 06:00 [entrez] AID - 10.1007/s11695-018-3459-6 [pii] AID - 10.1007/s11695-018-3459-6 [doi] PST - ppublish SO - Obes Surg. 2018 Dec;28(12):4014-4021. doi: 10.1007/s11695-018-3459-6.