PMID- 30109739
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 32
IP  - 12
DP  - 2018 Dec
TI  - Oral administration of powdered dried rhizomes of Curcuma longa L. (turmeric, 
      Zingiberaceae) is effective in the treatment of doxorubicin-induced kidney injury 
      in rats.
PG  - 2408-2416
LID - 10.1002/ptr.6176 [doi]
AB  - Curcumin is a polyphenol present in the rhizomes of the species Curcuma longa L. 
      ("turmeric," Zingiberaceae), which has been used for centuries as an 
      anti-inflammatory. We aimed to evaluate the anti-inflammatory effects of C. longa 
      in renal injury induced by doxorubicin (DOX, 3.5 mg.kg(-1) IV). We studied four 
      groups of Wistar rats: two groups with DOX-induced kidney injury, one fed with 
      standard food and another with standard food mixed with C. longa (5 mg.g(-1) ). 
      Two other control groups without kidney injury were fed with the same foods. We 
      measured albuminuria, body weight, and food intake every 2 weeks. After 8 weeks, 
      treatment with C. longa did not change albuminuria, but it significantly 
      attenuated the excretion of urinary inflammatory markers monocyte chemoattractant 
      protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) and significantly 
      attenuated immunostaining for desmin, vimentin, and ED-1(+) cells in renal 
      tissues of rats with DOX-induced kidney injury. In addition, treatment with 
      C. longa resulted in significantly lower glomerular and tubule interstitial 
      injury scores, compared with that in the DOX-STD group. In conclusion, 
      administration of powdered rhizomes of C. longa for 8 weeks to rats with 
      DOX-induced kidney injury did not reduce albuminuria but led to a significant 
      decrease in urinary inflammatory markers MCP-1 and TGF-beta and decreased 
      histopathological alterations and immunostaining for desmin, vimentin, and 
      ED-1(+) cells kidneys tissues.
CI  - (c) 2018 John Wiley & Sons, Ltd.
FAU - Russo, Enzo R
AU  - Russo ER
AUID- ORCID: 0000-0003-0282-6204
AD  - Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirao Preto, Sao 
      Paulo, Brazil.
FAU - Facincani, Inalda
AU  - Facincani I
AD  - Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirao Preto, Sao 
      Paulo, Brazil.
FAU - Nakazato, Katia C
AU  - Nakazato KC
AD  - Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirao Preto, Sao 
      Paulo, Brazil.
FAU - Coimbra, Terezila M
AU  - Coimbra TM
AD  - Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirao Preto, Sao 
      Paulo, Brazil.
FAU - Crevelin, Eduardo J
AU  - Crevelin EJ
AD  - Department of Chemistry, Faculty of Philosophy, Sciences and Letters at Ribeirao 
      Preto, University of Sao Paulo (USP), Ribeirao Preto, Sao Paulo, Brazil.
FAU - Pereira, Ana Maria S
AU  - Pereira AMS
AUID- ORCID: 0000-0002-3478-4718
AD  - University of Ribeirao Preto (UNAERP), Ribeirao Preto, Sao Paulo, Brazil.
FAU - Carmona, Fabio
AU  - Carmona F
AUID- ORCID: 0000-0001-5743-0325
AD  - Ribeirao Preto Medical School, University of Sao Paulo (USP), Ribeirao Preto, Sao 
      Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180815
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Plant Extracts)
RN  - 0 (Powders)
RN  - 80168379AG (Doxorubicin)
RN  - 856YO1Z64F (turmeric extract)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Administration, Oral
MH  - Albuminuria/chemically induced/drug therapy/urine
MH  - Animals
MH  - Curcuma/*chemistry
MH  - Curcumin/administration & dosage/pharmacology
MH  - Desiccation
MH  - Doxorubicin/*adverse effects
MH  - Kidney/drug effects/pathology
MH  - Kidney Diseases/*chemically induced/*drug therapy/pathology/urine
MH  - Male
MH  - Plant Extracts/*administration & dosage/pharmacology
MH  - Powders/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Rhizome/chemistry
MH  - Treatment Outcome
MH  - Zingiberaceae/chemistry
OTO - NOTNLM
OT  - Curcuma longa
OT  - Zingiberaceae
OT  - doxorubicin
OT  - herbal medicine
OT  - inflammation
OT  - proteinuria
EDAT- 2018/08/16 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/08/16 06:00
PHST- 2018/04/28 00:00 [received]
PHST- 2018/07/16 00:00 [revised]
PHST- 2018/07/17 00:00 [accepted]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/08/16 06:00 [entrez]
AID - 10.1002/ptr.6176 [doi]
PST - ppublish
SO  - Phytother Res. 2018 Dec;32(12):2408-2416. doi: 10.1002/ptr.6176. Epub 2018 Aug 
      15.