PMID- 30110046
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181114
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Print)
IS  - 0066-782X (Linking)
VI  - 111
IP  - 1
DP  - 2018 Jul
TI  - Effects of Coexistence Hypertension and Type II Diabetes on Heart Rate 
      Variability and Cardiorespiratory Fitness.
PG  - 64-72
LID - S0066-782X2018000700064 [pii]
LID - 10.5935/abc.20180105 [doi]
AB  - BACKGROUND: Type 2 diabetes Mellitus (T2DM) is associated with cardiac autonomic 
      dysfunction, which is an independent predictor of mortality in chronic diseases. 
      However, whether the coexistence of systemic arterial hypertension (HTN) with 
      DMT2 alters cardiac autonomic modulation remains unknown. OBJECTIVE: To evaluate 
      the influence of HTN on cardiac autonomic modulation and cardiorespiratory 
      fitness in subjects with DMT2. METHODS: 60 patients of both genders were 
      evaluated and allocated to two groups: DMT2 patients (n = 32; 51 +/- 7.5 years old) 
      and DMT2 + HTN patients (n = 28; 51 +/- 6.9 years old). RR intervals were obtained 
      during rest in supine position. Linear and nonlinear indices of heart rate 
      variability (HRV) were computed using Kubios HRV software. Pulmonary gas exchange 
      was measured breath-by-breath, using a portable telemetric system during maximal 
      incremental exercise testing on a cycle ergometer. Statistical analysis included 
      Shapiro-Wilk test followed by Student's t Test, Pearson correlation and linear 
      regression. RESULTS: We found that patients in the DMT2+HTN group showed lower 
      values of mean RR intervals (801.1 vs 871.5 ms), Shannon entropy (3 vs 3.2) and 
      fractal dimension SD 1 (9.5 vs 14.5), when contrasted with patients in the DMT2 
      group. Negative correlations were found between some HRV nonlinear indices and 
      exercise capacity indices. CONCLUSION: HTN negatively affects the cardiac 
      autonomic function in diabetic patients, who are already prone to develop 
      autonomic dysfunction. Strategies are need to improve cardiac autonomic 
      functionality in this population.
FAU - Bassi, Daniela
AU  - Bassi D
AD  - Departamento de Fisioterapia, Universidade Ceuma, Sao Luis, MA - Brazil.
FAU - Cabiddu, Ramona
AU  - Cabiddu R
AD  - Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP 
      - Brazil.
FAU - Mendes, Renata G
AU  - Mendes RG
AD  - Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP 
      - Brazil.
FAU - Tossini, Natalia
AU  - Tossini N
AD  - Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP 
      - Brazil.
FAU - Arakelian, Vivian M
AU  - Arakelian VM
AD  - Departamento de Fisioterapia, Universidade Nove de Julho, Sao Paulo, SP - Brazil.
FAU - Caruso, Flavia C R
AU  - Caruso FCR
AD  - Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP 
      - Brazil.
FAU - Bonjorno Junior, Jose C
AU  - Bonjorno Junior JC
AD  - Departamento de Medicina, Universidade Federal de Sao Carlos, Sao Carlos, SP - 
      Brazil.
FAU - Arena, Ross
AU  - Arena R
AD  - Departamento de Fisioterapia, Universidade de Illinois em Chicago, Chicago, IL - 
      EUA.
FAU - Borghi-Silva, Audrey
AU  - Borghi-Silva A
AD  - Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP 
      - Brazil.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
CIN - Arq Bras Cardiol. 2018 Jul;111(1):73-74. PMID: 30110047
CIN - Arq Bras Cardiol. 2018 Oct;111(4):640-642. PMID: 30365689
MH  - Autonomic Nervous System/*physiopathology
MH  - Cardiorespiratory Fitness/*physiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Diabetic Angiopathies/etiology/*physiopathology
MH  - Exercise Test
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Hypertension/complications/*physiopathology
MH  - Male
MH  - Middle Aged
PMC - PMC6078357
COIS- Potential Conflict of Interest No potential conflict of interest relevant to this 
      article was reported.
EDAT- 2018/08/16 06:00
MHDA- 2018/10/23 06:00
PMCR- 2018/07/01
CRDT- 2018/08/16 06:00
PHST- 2017/09/13 00:00 [received]
PHST- 2018/03/14 00:00 [accepted]
PHST- 2018/08/16 06:00 [entrez]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - S0066-782X2018000700064 [pii]
AID - 10.5935/abc.20180105 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2018 Jul;111(1):64-72. doi: 10.5935/abc.20180105.