PMID- 30110059
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20191210
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 33
IP  - 7
DP  - 2018 Jul
TI  - The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits 
      with acute massive pulmonary embolism1.
PG  - 577-587
LID - S0102-86502018000700577 [pii]
LID - 10.1590/s0102-865020180070000003 [doi]
AB  - PURPOSE: To investigate changes in the plasma concentrations of cardiac troponin 
      I (CTnI), thromboxane A2 (TXA2), prostaglandin I2 (PGI2) and endothelin-1 (ET-1) 
      in rabbits with massive pulmonary embolism (AMPE) and the impact of nitric oxide 
      inhalation (NOI) on these indices. METHODS: A total of 30 Japanese rabbits were 
      used to construct an MPE model and were divided into 3 groups equally (n=10), 
      including an EXP group (undergoing modeling alone), an NOI group (receiving NOI 2 
      h post-modeling) and a CON group (receiving intravenous physiological saline). 
      RESULTS: In the model group, plasma concentration of CTnI peaked at 16 h 
      following modeling (0.46+/-0.10 microg/ml) and significantly decreased following NOI. 
      Plasma levels of TXB2, PGI2 and ET-1 peaked at 12, 16 and 8 h following modeling, 
      respectively, and significantly decreased at different time points (0, 2, 4, 8, 
      12, 16, 20 and 24 h) following NOI. A significant correlation was observed 
      between the peak plasma CTnI concentration and peak TXB2, 6-keto prostaglandin 
      F1alpha and ET-1 concentrations in the model and NOI groups. CONCLUSION: Increases in 
      plasma TXA2, PGI2 and ET-1 levels causes myocardial damage in a rabbit model of 
      AMPE; however, NOI effectively down regulates the plasma concentration of these 
      molecules to produce a myocardial-protective effect.
FAU - Zhang, Zeming
AU  - Zhang Z
AD  - PhD, Department of Respiratory Medicine, Affiliated Zhou Pu Hospital, Shanghai 
      Health Medical College, China. Conception of the study, technical procedures, 
      manuscript writing, critical revision.
FAU - Li, Zheng
AU  - Li Z
AD  - Master, Department of Respiratory Medicine, Affiliated Hospital, Hebei 
      University, Baoding, China. Technical procedures, analysis of data, manuscript 
      writing.
FAU - Chen, Lu
AU  - Chen L
AD  - Bachelor, Department of Respiratory Medicine, Affiliated Hospital, Hebei 
      University, Baoding, China. Technical procedures, chart making.
FAU - Wang, Yancun
AU  - Wang Y
AD  - Bachelor s degree, Department of Neurology, Affiliated Zhou Pu Hospital, Shanghai 
      Health Medical College, China. Acquisition and interpretation of data.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Endothelin-1)
RN  - 0 (Troponin I)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 57576-52-0 (Thromboxane A2)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Acute Disease
MH  - Administration, Inhalation
MH  - Animals
MH  - Bronchodilator Agents/*pharmacology
MH  - Down-Regulation
MH  - Endothelin-1/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Epoprostenol/*blood
MH  - Female
MH  - Male
MH  - Nitric Oxide/*pharmacology
MH  - Pulmonary Embolism/*blood/*drug therapy/pathology
MH  - Rabbits
MH  - Random Allocation
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Thromboxane A2/*blood
MH  - Time Factors
MH  - Treatment Outcome
MH  - Troponin I/*blood
EDAT- 2018/08/16 06:00
MHDA- 2018/09/07 06:00
CRDT- 2018/08/16 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/06/09 00:00 [accepted]
PHST- 2018/08/16 06:00 [entrez]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
AID - S0102-86502018000700577 [pii]
AID - 10.1590/s0102-865020180070000003 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2018 Jul;33(7):577-587. doi: 10.1590/s0102-865020180070000003.