PMID- 30110089 OWN - NLM STAT- MEDLINE DCOM- 20180918 LR - 20191231 IS - 1809-452X (Electronic) IS - 1516-4446 (Print) IS - 1516-4446 (Linking) VI - 40 IP - 4 DP - 2018 Oct-Dec TI - Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels. PG - 367-375 LID - 10.1590/1516-4446-2017-2271 [doi] AB - OBJECTIVE: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. METHODS: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the open-field test, novel object recognition and step-down inhibitory avoidance test. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-line derived neurotrophic factor (GDNF) levels were evaluated in the hippocampus and frontal cortex. RESULTS: Hypericum impaired the acquisition of short- and long-term aversive memory in male rats, evaluated in the inhibitory avoidance test. Female rats had no immediate memory acquisition and decreased short-term memory acquisition in the inhibitory avoidance test. Hypericum also decreased the recognition index of male rats in the object recognition test. Female rats did not recognize the new object in either the short-term or the long-term memory tasks. Hypericum decreased BDNF in the hippocampus of male and female rats. Hypericum also decreased NGF in the hippocampus of female rats. CONCLUSIONS: The long-term administration of hypericum appears to cause significant cognitive impairment in rats, possibly through a reduction in the levels of neurotrophic factors. This effect was more expressive in females than in males. FAU - Valvassori, Samira S AU - Valvassori SS AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. AD - Laboratorio de Sinalizacao Neural e Psicofarmacologia, PPGCS, UNASAU, UNESC, Criciuma, SC, Brazil. FAU - Borges, Cenita AU - Borges C AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. FAU - Bavaresco, Daniela V AU - Bavaresco DV AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. AD - Laboratorio de Sinalizacao Neural e Psicofarmacologia, PPGCS, UNASAU, UNESC, Criciuma, SC, Brazil. FAU - Varela, Roger B AU - Varela RB AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. AD - Laboratorio de Sinalizacao Neural e Psicofarmacologia, PPGCS, UNASAU, UNESC, Criciuma, SC, Brazil. FAU - Resende, Wilson R AU - Resende WR AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. AD - Laboratorio de Sinalizacao Neural e Psicofarmacologia, PPGCS, UNASAU, UNESC, Criciuma, SC, Brazil. FAU - Peterle, Bruna R AU - Peterle BR AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. AD - Laboratorio de Sinalizacao Neural e Psicofarmacologia, PPGCS, UNASAU, UNESC, Criciuma, SC, Brazil. FAU - Arent, Camila O AU - Arent CO AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. FAU - Budni, Josiane AU - Budni J AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. FAU - Quevedo, Joao AU - Quevedo J AD - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), Unidade Academica de Ciencias da Saude (UNASAU), Universidade do Extremo Sul Catarinense (UNESC), Criciuma, SC, Brazil. AD - Department of Psychiatry and Behavioral Sciences, Center for Experimental Models in Psychiatry, The University of Texas Medical School at Houston, Houston, TX, USA. LA - eng PT - Journal Article DEP - 20180809 PL - Brazil TA - Braz J Psychiatry JT - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) JID - 100895975 RN - 0 (Nerve Growth Factors) RN - 0 (Plant Extracts) SB - IM MH - Animals MH - Cognition/*drug effects MH - Dose-Response Relationship, Drug MH - Female MH - Frontal Lobe/drug effects/*metabolism MH - Hippocampus/drug effects/*metabolism MH - *Hypericum MH - Locomotion/drug effects MH - Male MH - Memory/drug effects MH - Models, Animal MH - Nerve Growth Factors/*analysis/drug effects MH - Pattern Recognition, Physiological/drug effects MH - Plant Extracts/administration & dosage/*pharmacology MH - Random Allocation MH - Rats, Wistar MH - Sex Factors MH - Treatment Outcome PMC - PMC6899380 COIS- The authors report no conflicts of interest. EDAT- 2018/08/16 06:00 MHDA- 2018/09/19 06:00 PMCR- 2018/08/09 CRDT- 2018/08/16 06:00 PHST- 2017/03/09 00:00 [received] PHST- 2017/09/21 00:00 [accepted] PHST- 2018/08/16 06:00 [pubmed] PHST- 2018/09/19 06:00 [medline] PHST- 2018/08/16 06:00 [entrez] PHST- 2018/08/09 00:00 [pmc-release] AID - S1516-44462018005006101 [pii] AID - 10.1590/1516-4446-2017-2271 [doi] PST - ppublish SO - Braz J Psychiatry. 2018 Oct-Dec;40(4):367-375. doi: 10.1590/1516-4446-2017-2271. Epub 2018 Aug 9.