PMID- 30110090
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20191231
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Print)
IS  - 1516-4446 (Linking)
VI  - 40
IP  - 4
DP  - 2018 Oct-Dec
TI  - Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and 
      anxiety-like behavior in mice.
PG  - 376-381
LID - 10.1590/1516-4446-2017-2310 [doi]
AB  - OBJECTIVE: Sleep apnea has been associated with anxiety, but the mechanisms of 
      the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative 
      stress, which might enhance anxiety-like behavior in rodents. To clarify the 
      apnea-anxiety connection, we tested the effect of intermittent hypoxia, a model 
      of sleep apnea, on the anxiety behavior of mice. METHODS: The rodents were 
      exposed daily to 480 one-minute cycles of intermittent hypoxia to a nadir of 7+/-1% 
      inspiratory oxygen fraction or to a sham procedure with room air. After 7 days, 
      the mice from both groups were placed in an elevated plus maze and were video 
      recorded for 10 min to allow analysis of latency, frequency, and duration in open 
      and closed arms. Glyoxalase-1 (Glo1) and glutathione reductase-1 (GR1) were 
      measured in the cerebral cortex, hippocampus, and striatum by Western blotting. 
      RESULTS: Compared to controls, the intermittent hypoxia group displayed less 
      anxiety-like behavior, perceived by a statistically significant increase in the 
      number of entries and total time spent in open arms. A higher expression of GR1 
      in the cortex was also observed. CONCLUSION: The lack of a clear anxiety response 
      as an outcome of intermittent hypoxia exposure suggests the existence of 
      additional layers in the anxiety mechanism in sleep apnea, possibly represented 
      by sleepiness and irreversible neuronal damage.
FAU - Carissimi, Alicia
AU  - Carissimi A
AD  - Programa de Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Martinez, Denis
AU  - Martinez D
AD  - Programa de Pos-Graduacao em Cardiologia e Ciencias Cardiovasculares, UFRGS, 
      Porto Alegre, RS, Brazil.
AD  - Divisao de Cardiologia, Hospital de Clinicas de Porto Alegre (HCPA), UFRGS, Porto 
      Alegre, RS, Brazil.
AD  - Programa de Pos-Graduacao em Medicina, Ciencias Medicas, UFRGS, Porto Alegre, RS, 
      Brazil.
FAU - Kim, Lenise J
AU  - Kim LJ
AD  - Departamento de Psicobiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, SP, Brazil.
FAU - Fiori, Cintia Z
AU  - Fiori CZ
AD  - Programa de Pos-Graduacao em Cardiologia e Ciencias Cardiovasculares, UFRGS, 
      Porto Alegre, RS, Brazil.
AD  - Divisao de Cardiologia, Hospital de Clinicas de Porto Alegre (HCPA), UFRGS, Porto 
      Alegre, RS, Brazil.
FAU - Vieira, Luciana R
AU  - Vieira LR
AD  - Programa de Pos-Graduacao em Medicina, Ciencias Medicas, UFRGS, Porto Alegre, RS, 
      Brazil.
FAU - Rosa, Darlan P
AU  - Rosa DP
AD  - Programa de Pos-Graduacao em Medicina, Ciencias Medicas, UFRGS, Porto Alegre, RS, 
      Brazil.
AD  - Faculdade Cenecista de Bento Goncalves (CNEC), Bento Goncalves, RS, Brazil.
FAU - Pires, Gabriel N
AU  - Pires GN
AD  - Departamento de Psicobiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180809
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 4.4.1.5 (Lactoylglutathione Lyase)
SB  - IM
MH  - Animals
MH  - Anxiety/diagnosis/*etiology/physiopathology
MH  - Cerebral Cortex/enzymology
MH  - Corpus Striatum/enzymology
MH  - Disease Models, Animal
MH  - Glutathione Reductase/*analysis/metabolism
MH  - Hypoxia/*complications/enzymology/psychology
MH  - Lactoylglutathione Lyase/*analysis/metabolism
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Oxidative Stress/physiology
MH  - Sleep Apnea Syndromes/*complications/enzymology/physiopathology/psychology
PMC - PMC6899376
COIS- DM is co-owner of a sleep medicine clinic. GNP is currently an employee of 
      Springer Nature, although this position has no relation with the present article 
      or any of this author's academic activities. The other authors report no 
      conflicts of interest.
EDAT- 2018/08/16 06:00
MHDA- 2018/09/19 06:00
PMCR- 2018/08/09
CRDT- 2018/08/16 06:00
PHST- 2017/04/20 00:00 [received]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/08/16 06:00 [entrez]
PHST- 2018/08/09 00:00 [pmc-release]
AID - S1516-44462018005006102 [pii]
AID - 10.1590/1516-4446-2017-2310 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2018 Oct-Dec;40(4):376-381. doi: 10.1590/1516-4446-2017-2310. 
      Epub 2018 Aug 9.