PMID- 30110686
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20200427
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 97
IP  - 1
DP  - 2019
TI  - Whole-Body Plethysmography and Blood Gas Analysis in Patients with Acute 
      Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
PG  - 24-33
LID - 10.1159/000491096 [doi]
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart 
      disease (CHD) often occur together. However, COPD is underdiagnosed among CHD 
      patients. OBJECTIVES: This study investigated the prevalence of COPD and relevant 
      pulmonary function test (PFT) impairments in patients with acute myocardial 
      infarction (AMI). METHODS: Patients undergoing coronary angiography for AMI were 
      prospectively included. Body plethysmography, lung diffusing capacity, blood gas 
      analysis, and echocardiography were performed. The following patient subgroups 
      were compared: with versus without COPD, ST elevation myocardial infarction 
      (STEMI) versus non-STEMI (NSTEMI). The prevalence of PFT impairments was also 
      recorded. RESULTS: A total of 100 patients (51 with NSTEMI, 49 with STEMI) were 
      included. Twenty patients had diagnosed COPD, of whom 15 were diagnosed for the 
      first time; 80% of all COPD patients were not receiving COPD therapy. Patients 
      with COPD had higher maximum creatine kinase (p = 0.008) and troponin T (p = 
      0.054) levels than those without COPD. Hypoxaemia was more common in COPD 
      patients (lower oxygen saturation [p = 0.008] and partial pressure of oxygen 
      [PaO2] [p = 0.005]). PaO2 was significantly lower in STEMI compared with NSTEMI 
      (p = 0.017). Independent of a COPD diagnosis, 65 patients had relevant PFT 
      impairments. CONCLUSIONS: The high prevalence of undiagnosed COPD and relevant 
      pulmonary function impairments in this cohort of patients with AMI, and the fact 
      that pulmonary disease was untreated in the majority of COPD patients, highlight 
      the importance of a general pulmonary workup of patients with AMI. Furthermore, 
      patients with CHD should undergo screening for COPD, given the fact that COPD 
      patients had larger infarction size.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Dreher, Michael
AU  - Dreher M
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital Aachen, 
      Aachen, Germanymdreher@ukaachen.de.
FAU - Daher, Ayham
AU  - Daher A
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital Aachen, 
      Aachen, Germany.
FAU - Keszei, Andras
AU  - Keszei A
AD  - Department of Medical Informatics, University Hospital Aachen, Aachen, Germany.
FAU - Marx, Nikolaus
AU  - Marx N
AD  - Department of Cardiology, Angiology, and Intensive Care Medicine, University 
      Hospital Aachen, Aachen, Germany.
FAU - Muller, Tobias
AU  - Muller T
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital Aachen, 
      Aachen, Germany.
FAU - Cornelissen, Christian
AU  - Cornelissen C
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital Aachen, 
      Aachen, Germany.
FAU - Brandenburg, Vincent
AU  - Brandenburg V
AD  - Department of Cardiology, Angiology, and Intensive Care Medicine, University 
      Hospital Aachen, Aachen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180815
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
MH  - Blood Gas Analysis/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Hospital Mortality/trends
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*complications/mortality/surgery
MH  - *Percutaneous Coronary Intervention
MH  - Plethysmography, Whole Body/*methods
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/*complications/diagnosis/epidemiology
MH  - Registries
MH  - Risk Factors
MH  - Survival Rate/trends
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Chronic obstructive pulmonary disease
OT  - Pulmonary function tests
EDAT- 2018/08/16 06:00
MHDA- 2020/04/28 06:00
CRDT- 2018/08/16 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/06/15 00:00 [accepted]
PHST- 2018/08/16 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2018/08/16 06:00 [entrez]
AID - 000491096 [pii]
AID - 10.1159/000491096 [doi]
PST - ppublish
SO  - Respiration. 2019;97(1):24-33. doi: 10.1159/000491096. Epub 2018 Aug 15.