PMID- 30111442
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20220719
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 39
IP  - 4
DP  - 2018 Jul 1
TI  - Physician-diagnosed eczema is an independent risk factor for incident mouse skin 
      test sensitization in adults.
PG  - 311-315
LID - 10.2500/aap.2018.39.4137 [doi]
AB  - BACKGROUND: The disrupted skin barrier in eczema has been associated with an 
      increased risk of immunoglobulin E (IgE) sensitization in childhood. However, it 
      is unclear whether eczema, independent of atopy, is a risk factor for the 
      development of allergic sensitization in adulthood. OBJECTIVE: To determine if 
      skin barrier dysfunction, independent of atopy, is a risk factor for incident 
      sensitization in adult workers at a mouse production and research facility. 
      METHODS: New employees at The Jackson Laboratory enrolled in a cohort study and 
      underwent skin-prick testing (SPT) at baseline and every 6 months to mouse and to 
      a panel of aeroallergens (net wheal >/=3 mm indicated a positive SPT result). Mouse 
      allergen exposure was measured every 6 months by using personal air monitors. 
      Physician-diagnosed eczema was defined as self-reported physician-diagnosed 
      eczema. Cox proportional hazard modeling was used to examine the association 
      between baseline physician-diagnosed eczema and incident mouse skin test 
      sensitization and adjusted for potential confounders. RESULTS: The participants 
      (N = 394) were followed up for a median of 24 months. Fifty-four percent were 
      women, 89% were white, and 64% handled mice. At baseline, 7% of the participants 
      reported physician-diagnosed eczema and 9% reported current asthma; 61% had at 
      least one positive skin test result. At 30 months, 36% of those with eczema 
      versus 14% of those without eczema had developed a positive mouse skin test 
      result (p = 0.02, log-rank test). After adjusting for age, race, sex, smoking 
      status (current, former, never), current asthma, hay fever, the number of 
      positive SPT results at baseline, and mouse allergen exposure, 
      physician-diagnosed eczema was an independent risk factor for incident mouse SPT 
      sensitization (hazard ratio 5.6 [95% confidence interval, 2.1-15.2]; p = 0.001). 
      CONCLUSION: Among adult workers at a mouse production and research facility, 
      physician-diagnosed eczema was a risk factor for incident mouse sensitization, 
      independent of atopy, which indicated that a defect in skin barrier alone may 
      increase the risk of skin sensitization, not just in childhood, but throughout 
      life.
FAU - Grant, Torie
AU  - Grant T
AD  - From the Division of Pediatric Allergy/Immunology, Johns Hopkins School of 
      Medicine, Baltimore, Maryl.
FAU - Dantzer, Jennifer
AU  - Dantzer J
AD  - From the Division of Pediatric Allergy/Immunology, Johns Hopkins School of 
      Medicine, Baltimore, Maryl.
FAU - Keet, Corinne
AU  - Keet C
AD  - From the Division of Pediatric Allergy/Immunology, Johns Hopkins School of 
      Medicine, Baltimore, Maryl.
FAU - Peng, Roger
AU  - Peng R
AD  - Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins 
      University, Baltimore, Maryl.
FAU - Paigen, Beverly J
AU  - Paigen BJ
AD  - The Jackson Laboratory, Bar Harbor, Maine.
FAU - Krevans, Mary
AU  - Krevans M
AD  - The Jackson Laboratory, Bar Harbor, Maine.
FAU - Hagberg, Karol
AU  - Hagberg K
AD  - The Jackson Laboratory, Bar Harbor, Maine.
FAU - Curtin-Brosnan, Jean
AU  - Curtin-Brosnan J
AD  - From the Division of Pediatric Allergy/Immunology, Johns Hopkins School of 
      Medicine, Baltimore, Maryl.
FAU - Shreffler, Wayne
AU  - Shreffler W
AD  - Divsions of Allergy and Immunology, Department of Pediatrics, Massachusetts 
      General Hospital and Harvard Medical School, Boston, Massachusetts.
FAU - Matsui, Elizabeth C
AU  - Matsui EC
AD  - From the Division of Pediatric Allergy/Immunology, Johns Hopkins School of 
      Medicine, Baltimore, Maryl.
LA  - eng
GR  - K24 AI114769/AI/NIAID NIH HHS/United States
GR  - P2C HD042849/HD/NICHD NIH HHS/United States
GR  - R01 ES023447/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - *Animal Technicians
MH  - Animals
MH  - Eczema/diagnosis/*epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Mice
MH  - Occupational Exposure/*adverse effects
MH  - Proportional Hazards Models
MH  - Skin Tests
MH  - Young Adult
PMC - PMC6052172
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2018/08/17 06:00
MHDA- 2019/02/12 06:00
PMCR- 2018/07/01
CRDT- 2018/08/17 06:00
PHST- 2018/08/17 06:00 [entrez]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - AAP017-18 [pii]
AID - 10.2500/aap.2018.39.4137 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2018 Jul 1;39(4):311-315. doi: 10.2500/aap.2018.39.4137.