PMID- 30111706
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 6
IP  - 3
DP  - 2018 Aug 15
TI  - Messing with the Sentinels-The Interaction of Staphylococcus aureus with 
      Dendritic Cells.
LID - 10.3390/microorganisms6030087 [doi]
LID - 87
AB  - Staphylococcus aureus (S. aureus) is a dangerous pathogen as well as a frequent 
      colonizer, threatening human health worldwide. Protection against S. aureus 
      infection is challenging, as the bacteria have sophisticated strategies to escape 
      the host immune response. To maintain equilibrium with S. aureus, both innate and 
      adaptive immune effector mechanisms are required. Dendritic cells (DCs) are 
      critical players at the interface between the two arms of the immune system, 
      indispensable for inducing specific T cell responses. In this review, we 
      highlight the importance of DCs in mounting innate as well as adaptive immune 
      responses against S. aureus with emphasis on their role in S. aureus-induced 
      respiratory diseases. We also review what is known about mechanisms that S. 
      aureus has adopted to evade DCs or manipulate these cells to its advantage.
FAU - Darisipudi, Murthy N
AU  - Darisipudi MN
AUID- ORCID: 0000-0002-3315-4570
AD  - Department of Immunology, University Medicine Greifswald, 
      Ferdinand-Sauerbruch-Strasse DZ7, D-17475 Greifswald, Germany. 
      venkata.darisipudi@uni-greifswald.de.
FAU - Nordengrun, Maria
AU  - Nordengrun M
AUID- ORCID: 0000-0002-5749-8861
AD  - Department of Immunology, University Medicine Greifswald, 
      Ferdinand-Sauerbruch-Strasse DZ7, D-17475 Greifswald, Germany. 
      maria.nordengruen@uni-greifswald.de.
FAU - Broker, Barbara M
AU  - Broker BM
AUID- ORCID: 0000-0002-5020-8542
AD  - Department of Immunology, University Medicine Greifswald, 
      Ferdinand-Sauerbruch-Strasse DZ7, D-17475 Greifswald, Germany. 
      broeker@uni-greifswald.de.
FAU - Peton, Vincent
AU  - Peton V
AUID- ORCID: 0000-0003-1909-9189
AD  - Department of Immunology, University Medicine Greifswald, 
      Ferdinand-Sauerbruch-Strasse DZ7, D-17475 Greifswald, Germany. 
      vincent.peton@uni-greifswald.de.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180815
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC6163568
OTO - NOTNLM
OT  - S. aureus
OT  - adaptive immunity
OT  - dendritic cells
OT  - immune evasion
OT  - infection
OT  - innate immunity
COIS- The authors declare no conflict of interest.
EDAT- 2018/08/17 06:00
MHDA- 2018/08/17 06:01
PMCR- 2018/08/15
CRDT- 2018/08/17 06:00
PHST- 2018/07/06 00:00 [received]
PHST- 2018/08/12 00:00 [revised]
PHST- 2018/08/14 00:00 [accepted]
PHST- 2018/08/17 06:00 [entrez]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2018/08/17 06:01 [medline]
PHST- 2018/08/15 00:00 [pmc-release]
AID - microorganisms6030087 [pii]
AID - microorganisms-06-00087 [pii]
AID - 10.3390/microorganisms6030087 [doi]
PST - epublish
SO  - Microorganisms. 2018 Aug 15;6(3):87. doi: 10.3390/microorganisms6030087.