PMID- 30111828
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20191002
LR  - 20191007
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Aug 15
TI  - Improvement of physico-chemical properties of dextran-chitosan composite 
      scaffolds by addition of nano-hydroxyapatite.
PG  - 12180
LID - 10.1038/s41598-018-30720-2 [doi]
LID - 12180
AB  - Nano-hydroxyapatite was incorporated into polymer matrix of Dextran/Chitosan to 
      achieve a novel composite scaffold by freeze drying technique. The synthesized 
      composite scaffolds were recognized by different performances such as: X-ray 
      diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and Scanning 
      electron microscope (SEM). The results revealed the complex formation between 
      dextran and chitosan with an excellent dispersion of nHA inside the polymer 
      matrix. The SEM images showed the presence of interconnected pore structure 
      inside the scaffolds. The porosity of the composites was found to decrease from 
      82% to 67% by adding nanohydroxyapatite to the polymer matrix of 
      Dextran/Chitosan. The mechanical properties of the scaffolds were measured by 
      compression test. The obtained results verified that the presence of nHA can 
      noticeably enhance young's modulus and compressive strength of the composite 
      scaffolds. All the obtained results essentially recommend that these composites 
      can be a good candidate for bone tissue engineering applications.
FAU - El-Meliegy, Emad
AU  - El-Meliegy E
AD  - Department of ceramics, National research Centre, El-Tahrir street, Dokki, Cairo, 
      Egypt.
FAU - Abu-Elsaad, N I
AU  - Abu-Elsaad NI
AD  - Department of Physics, Faculty of Science, Zagazig University, Zagazig, Egypt. 
      nagwa.ibrahim@yahoo.com.
FAU - El-Kady, Abeer M
AU  - El-Kady AM
AD  - Department of glass, National research Centre, El-Tahrir street, Dokki, Cairo, 
      Egypt.
FAU - Ibrahim, Manar A
AU  - Ibrahim MA
AD  - Department of Physics, Faculty of Science, Zagazig University, Zagazig, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180815
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
PMC - PMC6093882
COIS- The authors declare no competing interests.
EDAT- 2018/08/17 06:00
MHDA- 2018/08/17 06:01
PMCR- 2018/08/15
CRDT- 2018/08/17 06:00
PHST- 2018/03/12 00:00 [received]
PHST- 2018/07/06 00:00 [accepted]
PHST- 2018/08/17 06:00 [entrez]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2018/08/17 06:01 [medline]
PHST- 2018/08/15 00:00 [pmc-release]
AID - 10.1038/s41598-018-30720-2 [pii]
AID - 30720 [pii]
AID - 10.1038/s41598-018-30720-2 [doi]
PST - epublish
SO  - Sci Rep. 2018 Aug 15;8(1):12180. doi: 10.1038/s41598-018-30720-2.