PMID- 30112025
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 16
IP  - 2
DP  - 2018 Aug
TI  - Evaluation of blood vessel injury, oxidative stress and circulating inflammatory 
      factors in an L-NAME-induced preeclampsia-like rat model.
PG  - 585-594
LID - 10.3892/etm.2018.6217 [doi]
AB  - Preeclampsia is a pregnancy-specific disease characterized by hypertension as 
      well as proteinuria after the 20th week of pregnancy. Animal models are effective 
      tools for studying the pathogenesis, diagnostic criteria and treatment methods of 
      preeclampsia. The present study sought to establish and evaluate a 
      preeclampsia-like Sprague Dawley (SD) rat model using N-nitro-L-arginine methyl 
      ester (L-NAME). Rats were randomly assigned to 7 groups (n=10 in each): Control 
      rats and rats treated with low-dose L-NAME (40 mg/kg body weight/day) starting 
      from gestational day (GD) 9, medium-L-NAME (75 mg/kg body weight/day) starting 
      from GD 9 (9D ML group), high-dose L-NAME (125 mg/kg body weight/day) starting 
      from GD 9, low-dose L-NAME starting from GD 10, medium-dose L-NAME starting from 
      GD 10 and high-dose L-NAME starting from GD 10. Blood pressure (BP), 24-h 
      proteinuria, fetal intrauterine growth, histopathological changes, the plasma 
      soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PLGF) ratio 
      and cytokine levels were evaluated. Elevated BP, increased urinary albumin 
      excretion, severe endotheliosis, mesangial expansion and increased sFlt-1/PLGF 
      ratios were observed in the experimental groups compared with the control group 
      (P<0.05), particularly in the 9D ML group. The results of the present study may 
      optimize the conditions of the previously established L-NAME-induced preeclampsia 
      SD rat model and aid further study into the pathogenesis of preeclampsia.
FAU - Shu, Wen
AU  - Shu W
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Li, Hanying
AU  - Li H
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
AD  - Graduate School of Medicine, Tianjin Medical University, Tianjin 300070, P.R. 
      China.
FAU - Gong, Hao
AU  - Gong H
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
AD  - Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China.
FAU - Zhang, Mei
AU  - Zhang M
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Niu, Xiulong
AU  - Niu X
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Ma, Yongqiang
AU  - Ma Y
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Cai, Wei
AU  - Cai W
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Yang, Guohong
AU  - Yang G
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Wei, Maoti
AU  - Wei M
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Yang, Ning
AU  - Yang N
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
FAU - Li, Yuming
AU  - Li Y
AD  - Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, 
      Pingjin Hospital Heart Center, Tianjin 300162, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180524
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6090470
OTO - NOTNLM
OT  - hypertension
OT  - nitric oxide
OT  - oxidative stress
OT  - preeclampsia
OT  - proteinuria
EDAT- 2018/08/17 06:00
MHDA- 2018/08/17 06:01
PMCR- 2018/05/24
CRDT- 2018/08/17 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2018/04/13 00:00 [accepted]
PHST- 2018/08/17 06:00 [entrez]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2018/08/17 06:01 [medline]
PHST- 2018/05/24 00:00 [pmc-release]
AID - ETM-0-0-6217 [pii]
AID - 10.3892/etm.2018.6217 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Aug;16(2):585-594. doi: 10.3892/etm.2018.6217. Epub 2018 May 
      24.