PMID- 30112278 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230928 IS - 2213-5979 (Print) IS - 2213-5979 (Electronic) IS - 2213-5979 (Linking) VI - 11 DP - 2018 Sep TI - The application of frequency-domain photoacoustics to temperature-dependent measurements of the Gruneisen parameter in lipids. PG - 56-64 LID - 10.1016/j.pacs.2018.07.005 [doi] AB - The Gruneisen parameter is an essential factor in biomedical photoacoustic (PA) diagnostics. In most PA imaging applications, the variation of the Gruneisen parameter with tissue type is insignificant. This is not the case for PA imaging and characterization of lipids, as they have a very distinct Gruneisen parameter compared with other tissue types. One example of PA applications involving lipids is the imaging and characterization of atherosclerotic plaques. Intravascular photoacoustic (IVPA) imaging is a promising diagnostic tool that can evaluate both plaque severity and composition. The literature for IVPA has mainly focused on using the difference in absorption coefficients between plaque components and healthy arterial tissues. However, the Gruneisen parameters for lipids and their behavior with temperature have not been well established in the literature. In this study we employ frequency-domain photoacoustic measurements to estimate the Gruneisen parameter by virtue of the ability of this modality to independently measure both the absorption coefficient and the Gruneisen parameter through the use of the phase channel. The values of the Gruneisen parameters of some lipids are calculated as functions of temperature in the range 25-45 degrees C. FAU - Liang, Simon AU - Liang S AD - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada. AD - Department of Medicine, University of British Columbia, Canada. FAU - Lashkari, Bahman AU - Lashkari B AD - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada. FAU - Choi, Sung Soo Sean AU - Choi SSS AD - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada. FAU - Ntziachristos, Vasilis AU - Ntziachristos V AD - Institute for Biological and Medical Imaging, Technische Universitat Munchen and Helmholtz Zentrum Munchen, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany. FAU - Mandelis, Andreas AU - Mandelis A AD - Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada. AD - Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, M5S 3G9, Canada. AD - Institute for Biological and Medical Imaging, Technische Universitat Munchen and Helmholtz Zentrum Munchen, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany. LA - eng PT - Journal Article DEP - 20180803 PL - Germany TA - Photoacoustics JT - Photoacoustics JID - 101622604 PMC - PMC6091231 OTO - NOTNLM OT - Atherosclerosis OT - Frequency-domain biomedical photoacoustics OT - Gruneisen parameter OT - Intravascular imaging OT - Ultrasound EDAT- 2018/08/17 06:00 MHDA- 2018/08/17 06:01 PMCR- 2018/08/03 CRDT- 2018/08/17 06:00 PHST- 2018/03/30 00:00 [received] PHST- 2018/07/15 00:00 [revised] PHST- 2018/07/26 00:00 [accepted] PHST- 2018/08/17 06:00 [entrez] PHST- 2018/08/17 06:00 [pubmed] PHST- 2018/08/17 06:01 [medline] PHST- 2018/08/03 00:00 [pmc-release] AID - S2213-5979(18)30013-2 [pii] AID - 10.1016/j.pacs.2018.07.005 [doi] PST - epublish SO - Photoacoustics. 2018 Aug 3;11:56-64. doi: 10.1016/j.pacs.2018.07.005. eCollection 2018 Sep.