PMID- 30112878
OWN - NLM
STAT- Publisher
LR  - 20240228
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
DP  - 2018 May 31
TI  - Higher Prevalence and Progression Rate of Chronic Kidney Disease in Elderly 
      Patients with Type 2 Diabetes Mellitus.
AB  - BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and 
      progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). 
      METHODS: We investigated the medical records of 190 elderly patients (65 years or 
      older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration 
      was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR) 
      <60 mL/min/1.73 m(2) and/or the presence of albuminuria. RESULTS: The mean age was 
      70.4 years and mean diabetes duration was 10.6 years. Among all the participants, 
      113 patients (59.5%) had CKD. The eGFR was significantly decreased between 
      baseline (65.7+/-15.0 mL/min/1.73 m(2)) and the end of follow-up (52.7+/-17.5 
      mL/min/1.73 m(2), P<0.001). At the end of follow-up, the prevalence of eGFR <60 
      mL/min/1.73 m(2) had increased by 61.6% (at baseline, 44.2%). Furthermore, in 
      patients with eGFR >/=60 mL/min/1.73 m(2), the progression rate to more than CKD 
      stage 3 was 39.6% at the end of follow-up; 30.2% of elderly diabetic patients had 
      progressed to albuminuria from normoalbuminuria. Kaplan-Meier analysis showed 
      that the time interval to worsening nephropathy was significantly shorter in 
      elderly patients with diabetes duration >/=10 years than in those with diabetes 
      duration <5 years (P=0.018). CONCLUSION: CKD was commonly observed in older 
      patients with T2DM, and the progression rate to CKD is also high. Consequently, 
      it is important to identify and manage CKD as early as possible in elderly 
      patients with T2DM, especially in those with diabetes duration >/=10 years.
CI  - Copyright (c) 2018 Korean Diabetes Association.
FAU - Kim, Kyung Soo
AU  - Kim KS
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University 
      School of Medicine, Seongnam, Korea.
FAU - Park, Seok Won
AU  - Park SW
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University 
      School of Medicine, Seongnam, Korea.
FAU - Cho, Yong Wook
AU  - Cho YW
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University 
      School of Medicine, Seongnam, Korea.
FAU - Kim, Soo Kyung
AU  - Kim SK
AUID- ORCID: 0000-0002-2601-3438
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University 
      School of Medicine, Seongnam, Korea. imdrksk@cha.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180531
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
OTO - NOTNLM
OT  - Aged
OT  - Albuminuria
OT  - Diabetes mellitus, type 2
OT  - Morbidity
OT  - Renal insufficiency, chronic
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2018/08/17 06:00
MHDA- 2018/08/17 06:00
CRDT- 2018/08/17 06:00
PHST- 2017/10/23 00:00 [received]
PHST- 2018/03/18 00:00 [accepted]
PHST- 2018/08/17 06:00 [entrez]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
AID - 42.e19 [pii]
PST - aheadofprint
SO  - Diabetes Metab J. 2018 May 31.