PMID- 30113522
OWN - NLM
STAT- MEDLINE
DCOM- 20190814
LR  - 20231005
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 51
IP  - 1
DP  - 2019 Jan
TI  - Equivalent Hypertrophy and Strength Gains in beta-Hydroxy-beta-Methylbutyrate- or 
      Leucine-supplemented Men.
PG  - 65-74
LID - 10.1249/MSS.0000000000001752 [doi]
AB  - Ingestion of proteins with high leucine content during resistance training (RT) 
      can augment hypertrophy. Some data suggest that a leucine metabolite, beta-hydroxy, 
      beta-methylbutyrate (HMB), is substantially more anabolically efficacious than 
      leucine. PURPOSE: We aimed to test whether supplementation with HMB versus 
      leucine, added to whey protein, would result in differential muscle hypertrophy 
      and strength gains in young men performing RT. METHODS: Twenty-six 
      resistance-trained men (23 +/- 2 yr) performed 12 wk of RT with three phases. Phase 
      1: 8 wk of periodized RT (three training sessions per week). Phase 2: 2 wk 
      overreaching period (five sessions per week). Phase 3: 2 wk taper (three sessions 
      per week). Participants were randomly assigned to twice daily ingestion of: whey 
      protein (25 g) plus HMB (1.5 g) (whey+HMB; n = 13) or whey protein (25 g) plus 
      leucine (1.5 g) (whey+leu; n = 13). Skeletal muscle biopsies were performed 
      before and after RT. Measures of fat- and bone-free mass, vastus lateralis (VL) 
      muscle thickness and muscle cross-sectional area (CSA) (both by ultrasound), 
      muscle fiber CSA, and 1-repetition maximum (1-RM) strength tests were determined. 
      RESULTS: We observed increases in fat- and bone-free mass, VL muscle thickness, 
      muscle CSA and fiber type CSA and 1-RM strength with no differences between 
      groups at any phase. We observed no differences between groups or time-group 
      interactions in hormone concentrations at any phase of the RT program. 
      CONCLUSIONS: beta-Hydroxy-beta-methylbutyrate added to whey did not result in greater 
      increases in any measure of muscle mass, strength, or hormonal concentration 
      compared to leucine added to whey. Our results show that HMB is no more effective 
      in stimulating RT-induced hypertrophy and strength gains than leucine.
FAU - Jakubowski, Josephine S
AU  - Jakubowski JS
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - Wong, Edwin P T
AU  - Wong EPT
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - Nunes, Everson A
AU  - Nunes EA
AD  - Department of Physiological Sciences, Federal University of Santa Catarina, 
      Florianopolis, BRAZIL.
FAU - Noguchi, Kenneth S
AU  - Noguchi KS
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - Vandeweerd, Joshua K
AU  - Vandeweerd JK
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - Murphy, Kevin T
AU  - Murphy KT
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - Morton, Robert W
AU  - Morton RW
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - McGlory, Chris
AU  - McGlory C
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
FAU - Phillips, Stuart M
AU  - Phillips SM
AD  - Department of Kinesiology, McMaster University, Ontario, CANADA.
LA  - eng
PT  - Journal Article
PT  - Pragmatic Clinical Trial
PT  - Randomized Controlled Trial
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (IGF1 protein, human)
RN  - 0 (Performance-Enhancing Substances)
RN  - 0 (Valerates)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 3F752311CD (beta-hydroxyisovaleric acid)
RN  - 3XMK78S47O (Testosterone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - GMW67QNF9C (Leucine)
RN  - WI4X0X7BPJ (Hydrocortisone)
EIN - Med Sci Sports Exerc. 2021 Jan;53(1):247. PMID: 33323831
MH  - Adult
MH  - Biopsy
MH  - Body Composition
MH  - Creatine Kinase/blood
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Human Growth Hormone/blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Leucine/*administration & dosage
MH  - Male
MH  - Muscle Strength/*physiology
MH  - Muscle, Skeletal/*anatomy & histology/diagnostic imaging/*physiology
MH  - Performance-Enhancing Substances/*administration & dosage
MH  - *Resistance Training
MH  - Testosterone/blood
MH  - Ultrasonography
MH  - Valerates/*administration & dosage
MH  - Young Adult
PMC - PMC6303132
EDAT- 2018/08/17 06:00
MHDA- 2019/08/15 06:00
PMCR- 2018/12/21
CRDT- 2018/08/17 06:00
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2019/08/15 06:00 [medline]
PHST- 2018/08/17 06:00 [entrez]
PHST- 2018/12/21 00:00 [pmc-release]
AID - MSS51088 [pii]
AID - 10.1249/MSS.0000000000001752 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2019 Jan;51(1):65-74. doi: 10.1249/MSS.0000000000001752.