PMID- 30113763
OWN - NLM
STAT- MEDLINE
DCOM- 20190129
LR  - 20190129
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 62
IP  - 6
DP  - 2018 Dec
TI  - Hyperbaric oxygen treatment for the management of radiation-induced xerostomia.
PG  - 841-846
LID - 10.1111/1754-9485.12789 [doi]
AB  - INTRODUCTION: Hyperbaric oxygen therapy (HBOT) is widely used for the treatment 
      of the late effects of radiation therapy. We report a prospective observational 
      cohort study of 51 patients designed to examine the effectiveness of hyperbaric 
      oxygen treatment (HBOT) for xerostomia following radiotherapy. METHODS: Objective 
      (saliva volume) and subjective (quality of life scoring and visual analogue scale 
      (VAS) of discomfort) measurements associated with xerostomia were compared prior 
      to commencement of HBOT, after 30 sessions (over 6 weeks) of HBOT at 243 kPa for 
      90 minutes daily for five days per week and at 6-week review (12 weeks from 
      commencement). RESULTS: One hundred and one courses of treatment in 99 patients 
      were examined. For 53 (53%) courses in 51 patients, data were recorded before and 
      after HBOT and so could be included in the analysis. Thirty-four (34%) of these 
      patients had complete data for all three time points. The unit of study was per 
      treatment course, not per person. There were no major complications to HBOT. 
      There was a statistically significant difference in saliva volume following HBOT 
      (P = 0.016). The mean saliva volume increase was 0.9 mL over a 5-min collection 
      period (95% CI 0.2-1.5). There was also a statistically significant improvement 
      in discomfort after HBOT (P < 0.001) and QOL (P < 0.001). The mean visual 
      analogue scale for discomfort (VAS on a 0-10 scale) score decreased by 1.4 units 
      (95% CI 0.7-2.1), whilst the mean QOL score was 10 points lower after treatment 
      (95% CI 5.9-14.4). CONCLUSION: Hyperbaric oxygen therapy may be a safe and 
      effective treatment for symptoms of xerostomia after radiation therapy and should 
      be considered when available.
CI  - (c) 2018 The Royal Australian and New Zealand College of Radiologists.
FAU - Sherlock, Susannah
AU  - Sherlock S
AUID- ORCID: 0000-0002-3925-3086
AD  - Hyperbaric Medicine Unit, Royal Brisbane and Women's Hospital, Brisbane, 
      Queensland, Australia.
AD  - Anaesthesia and Perioperative Services, Royal Brisbane and Women's Hospital, 
      Brisbane, Queensland, Australia.
AD  - Faculty of Medicine, The University of Queensland, Brisbane, Queensland, 
      Australia.
FAU - Way, Mandy
AU  - Way M
AD  - QIMR Berghofer Institute, Biostatistics, Brisbane, Queensland, Australia.
FAU - Tabah, Alexis
AU  - Tabah A
AD  - Hyperbaric Medicine Unit, Royal Brisbane and Women's Hospital, Brisbane, 
      Queensland, Australia.
AD  - Faculty of Medicine, The University of Queensland, Brisbane, Queensland, 
      Australia.
AD  - Intensive Care Unit, Redcliffe Hospital, Redcliffe, Queensland, Australia.
LA  - eng
GR  - The Australian and New Zealand College of Anaesthetists/
PT  - Journal Article
PT  - Observational Study
DEP - 20180816
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*radiotherapy
MH  - Pain Measurement
MH  - Quality of Life
MH  - Radiation Injuries/*therapy
MH  - Treatment Outcome
MH  - Xerostomia/*etiology/*therapy
OTO - NOTNLM
OT  - head and neck neoplasm
OT  - hyperbaric oxygenation
OT  - observational study
OT  - radiation therapy
OT  - xerostomia
EDAT- 2018/08/17 06:00
MHDA- 2019/01/30 06:00
CRDT- 2018/08/17 06:00
PHST- 2018/04/10 00:00 [received]
PHST- 2018/07/14 00:00 [accepted]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2019/01/30 06:00 [medline]
PHST- 2018/08/17 06:00 [entrez]
AID - 10.1111/1754-9485.12789 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2018 Dec;62(6):841-846. doi: 10.1111/1754-9485.12789. 
      Epub 2018 Aug 16.