PMID- 30115079 OWN - NLM STAT- MEDLINE DCOM- 20190314 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 20 IP - 1 DP - 2018 Aug 16 TI - Myocardial native T2 measurement to differentiate light-chain and transthyretin cardiac amyloidosis and assess prognosis. PG - 58 LID - 10.1186/s12968-018-0478-3 [doi] LID - 58 AB - BACKGROUND: To assess the diagnostic and prognosis value of myocardial native T2 measurement in the distinction between Light-chain (AL) and Transthyretin (ATTR) cardiac amyloidosis (CA). METHODS: Forty-four patients with CA (24 AL; 20 ATTR) and 40 healthy subjects underwent 1.5 T cardiovascular magnetic resonance (CMR). They all underwent T1 and T2 mapping (modified Look-Locker inversion recovery), cine and late gadolinium enhancement (LGE) imaging. The Query Amyloid Late Enhancement (QALE) score, myocardial native T2, T1 and extra cellular volume fraction (ECV) were calculated for all patients. RESULTS: Of the 44 patients, 36 (82%) exhibited enhancement on LGE images. Mean QALE score of AL (7.9 +/- 6) and ATTR (10.5 +/- 5) patients were similar (p = 0.6). Myocardial native T2 was significantly (p < 0.0001) higher in AL (63.2 +/- 4.7 ms) than in ATTR (56.2 +/- 3.1 ms) patients, and both higher (p < 0.001) than healthy subjects (51.1 +/- 3.1 ms). Myocardial native T2 was highly correlated with myocardial native T1 (Spearman's rho = 0.79; p < 0.001) and exhibited higher diagnostic performance than T1 to separate AL and ATTR patients: the area under curve (AUC) of T2 was 0.94 (95% CI: 0.86-1, p < 0.001) and the AUC of T1 was 0.77 (95% CI: 0.62-0.91, p = 0.03). Myocardial native T2 did not impact overall survival in patients (HR 1.03 (0.94-1.12); p = 0.53) in contrast to ECV that was the best predictor of outcome (HR 1.66 per 0.1 increase in ECV (1.24-2.22); p = 0.0006). CONCLUSIONS: Myocardial native T2 significantly is increased in CA, especially in AL patients in comparison to ATTR patients. Myocardial native T2 does not impact survival in CA patients in contrast to ECV that was the best predictor of outcome. TRIAL REGISTRATION: Trial Registration and unique number: CNIL cardio 1778041. Date of registration: 20 December 2012. FAU - Ridouani, Fourat AU - Ridouani F AUID- ORCID: 0000-0003-2582-464X AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. ridouanifourat@gmail.com. FAU - Damy, Thibaud AU - Damy T AD - Cardiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, Creteil, France. AD - National Referal Centre for Cardiac Amyloidoses, Henri Mondor Hospital, Creteil, France. FAU - Tacher, Vania AU - Tacher V AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. FAU - Derbel, Haytham AU - Derbel H AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. FAU - Legou, Francois AU - Legou F AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. FAU - Sifaoui, Islem AU - Sifaoui I AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. FAU - Audureau, Etienne AU - Audureau E AD - Public Health Department, Henri Mondor Hospital, CEpiA EA7376, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, Creteil, France. FAU - Bodez, Diane AU - Bodez D AD - Cardiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, Creteil, France. AD - National Referal Centre for Cardiac Amyloidoses, Henri Mondor Hospital, Creteil, France. FAU - Rahmouni, Alain AU - Rahmouni A AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. FAU - Deux, Jean-Francois AU - Deux JF AD - Radiology Department, Henri Mondor Hospital, University Paris Est Creteil, Assistance Publique-Hopitaux de Paris, 51 av Mal de Lattre de Tassigny, 94000, Creteil, France. AD - National Referal Centre for Cardiac Amyloidoses, Henri Mondor Hospital, Creteil, France. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180816 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) RN - Amyloidosis, Hereditary, Transthyretin-Related SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Amyloid Neuropathies, Familial/*diagnostic imaging/pathology MH - Cardiomyopathies/*diagnostic imaging/pathology MH - Contrast Media/administration & dosage MH - Diagnosis, Differential MH - Female MH - Humans MH - Immunoglobulin Light-chain Amyloidosis/*diagnostic imaging/pathology MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Predictive Value of Tests MH - Prognosis MH - Reproducibility of Results MH - Retrospective Studies PMC - PMC6097442 OTO - NOTNLM OT - Amyloidosis OT - CMR OT - T2 mapping COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Our local ethics committee (Hopital Henri-Mondor) approved the research and consent was obtained for all our patients. CONSENT FOR PUBLICATION: A written informed consent for publication was obtained from all the participant in the study. COMPETING INTERESTS: Author(s) declare(s) that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/08/18 06:00 MHDA- 2019/03/15 06:00 PMCR- 2018/08/16 CRDT- 2018/08/18 06:00 PHST- 2017/12/29 00:00 [received] PHST- 2018/07/19 00:00 [accepted] PHST- 2018/08/18 06:00 [entrez] PHST- 2018/08/18 06:00 [pubmed] PHST- 2019/03/15 06:00 [medline] PHST- 2018/08/16 00:00 [pmc-release] AID - S1097-6647(23)00595-1 [pii] AID - 478 [pii] AID - 10.1186/s12968-018-0478-3 [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2018 Aug 16;20(1):58. doi: 10.1186/s12968-018-0478-3.