PMID- 30115946
OWN - NLM
STAT- MEDLINE
DCOM- 20191030
LR  - 20211204
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Aug 16
TI  - Differential expression of serum biomarkers in hemodialysis patients with mild 
      cognitive decline: A prospective single-center cohort study.
PG  - 12250
LID - 10.1038/s41598-018-29760-5 [doi]
LID - 12250
AB  - Studies suggest that hemodialysis patients are at a higher risk for cognitive 
      decline than healthy individuals; however, underlying mechanisms have not been 
      fully elucidated. We aimed to investigate the roles of serum biomarkers, such as 
      brain-derived neurotrophic factor (BDNF), inflammatory cytokines, fibroblast 
      growth factor (FGF)-23 and its co-receptor alpha-klotho and platelet (PLT) count in 
      mild cognitive decline (MCD) of patients undergoing hemodialysis in this 
      prospective cohort study. Serum levels of BDNF, tumour necrosis factor (TNF)-alpha, 
      interleukin (IL)-6 and the number of PLT were significantly altered in the MCD 
      group compared with those in healthy controls (HCs) or those with normal 
      cognitive function (NCF). Although serum alpha-klotho and FGF-23 levels were 
      significantly altered in the MCD group, there were no statistical differences 
      between the MCD and NCF groups. Serum BDNF levels and PLT counts were 
      significantly correlated with cognitive test scores. Receiver operating 
      characteristic (ROC) curves demonstrated that BDNF and PLT were potential 
      biomarkers for improved MCD diagnosis in patients with hemodialysis. These 
      findings suggest that hemodialysis-related MCD is associated with altered BDNF, 
      TNF-alpha and IL-6 levels as well as PLT counts and that serum BDNF levels and PLT 
      counts are potential biomarkers for hemodialysis-related MCD diagnosis.
FAU - Zhu, Bin
AU  - Zhu B
AD  - Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China.
FAU - Jin, Li-Na
AU  - Jin LN
AD  - The Blood Purification Center, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China.
FAU - Shen, Jian-Qin
AU  - Shen JQ
AD  - The Blood Purification Center, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China.
FAU - Liu, Jin-Feng
AU  - Liu JF
AD  - The Blood Purification Center, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China.
FAU - Jiang, Ri-Yue
AU  - Jiang RY
AD  - Department of Radiation Oncology, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China.
FAU - Yang, Ling
AU  - Yang L
AD  - Department of Cardiology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Luo, Ai-Lin
AU  - Luo AL
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Miao, Li-Ying
AU  - Miao LY
AD  - The Blood Purification Center, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China. lymiao@sina.com.
FAU - Yang, Chun
AU  - Yang C
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. chunyang@tjh.tjmu.edu.cn.
LA  - eng
GR  - 81703482/National Natural Science Foundation of China (National Science 
      Foundation of China)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180816
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (FGF23 protein, human)
RN  - 7Q7P4S7RRE (Fibroblast Growth Factor-23)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cognitive Dysfunction/*blood/*genetics/physiopathology
MH  - Cohort Studies
MH  - Female
MH  - Fibroblast Growth Factor-23
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
MH  - *Renal Dialysis
PMC - PMC6095882
COIS- The authors declare no competing interests.
EDAT- 2018/08/18 06:00
MHDA- 2019/10/31 06:00
PMCR- 2018/08/16
CRDT- 2018/08/18 06:00
PHST- 2018/01/08 00:00 [received]
PHST- 2018/07/18 00:00 [accepted]
PHST- 2018/08/18 06:00 [entrez]
PHST- 2018/08/18 06:00 [pubmed]
PHST- 2019/10/31 06:00 [medline]
PHST- 2018/08/16 00:00 [pmc-release]
AID - 10.1038/s41598-018-29760-5 [pii]
AID - 29760 [pii]
AID - 10.1038/s41598-018-29760-5 [doi]
PST - epublish
SO  - Sci Rep. 2018 Aug 16;8(1):12250. doi: 10.1038/s41598-018-29760-5.