PMID- 30116179
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 12
DP  - 2018
TI  - Acute MDMA and Nicotine Co-administration: Behavioral Effects and Oxidative 
      Stress Processes in Mice.
PG  - 149
LID - 10.3389/fnbeh.2018.00149 [doi]
LID - 149
AB  - 3,4-Methylenedioxy-methylamphetamine (MDMA), a synthetic substance commonly known 
      as ecstasy, is a worldwide recreational drug of abuse. As MDMA and nicotine 
      activate the same neuronal pathways, we examined the influence of 
      co-administration of nicotine (0.05 mg/kg) and MDMA (1 mg/kg) on cognitive 
      processes, nicotine-induced behavioral sensitization and on processes linked with 
      oxidative stress and alpha7 nicotinic acetylcholine receptors (nAChRs) expression in 
      the brain of male Swiss mice. For behavioral study the passive avoidance (PA) 
      test and locomotor sensitization paradigm were used. Also, the oxidative stress 
      parameters as well as expression levels of alpha7 nAChRs in prefrontal cortex and 
      hippocampus of mice treated with MDMA alone or in combination with nicotine were 
      assessed. The results revealed that MDMA injections as well as co-administrations 
      of MDMA and nicotine improved memory consolidation in male Swiss mice tested in 
      PA task. Furthermore, one of the main findings of the present study is that MDMA 
      increased locomotor activity in nicotine-sensitized mice. Our study showed for 
      the first time strong behavioral and biochemical interactions between nicotine 
      and MDMA. Both drugs are very often used in combination, especially by young 
      people, thus these results may help explaining why psychoactive substances are 
      being co-abused and why this polydrug administration is still a social problem.
FAU - Budzynska, Barbara
AU  - Budzynska B
AD  - Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 
      Lublin, Poland.
FAU - Wnorowski, Artur
AU  - Wnorowski A
AD  - Department of Biopharmacy, Medical University of Lublin, Lublin, Poland.
FAU - Kaszubska, Katarzyna
AU  - Kaszubska K
AD  - Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 
      Lublin, Poland.
FAU - Biala, Grazyna
AU  - Biala G
AD  - Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 
      Lublin, Poland.
FAU - Kruk-Slomka, Marta
AU  - Kruk-Slomka M
AD  - Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 
      Lublin, Poland.
FAU - Kurzepa, Jacek
AU  - Kurzepa J
AD  - Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.
FAU - Boguszewska-Czubara, Anna
AU  - Boguszewska-Czubara A
AD  - Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20180802
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC6082960
OTO - NOTNLM
OT  - MDMA
OT  - behavioral sensitization
OT  - cholinergic receptors
OT  - memory
OT  - nicotine
OT  - oxidative stress
EDAT- 2018/08/18 06:00
MHDA- 2018/08/18 06:01
PMCR- 2018/01/01
CRDT- 2018/08/18 06:00
PHST- 2018/04/07 00:00 [received]
PHST- 2018/06/28 00:00 [accepted]
PHST- 2018/08/18 06:00 [entrez]
PHST- 2018/08/18 06:00 [pubmed]
PHST- 2018/08/18 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2018.00149 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2018 Aug 2;12:149. doi: 10.3389/fnbeh.2018.00149. 
      eCollection 2018.