PMID- 30116540
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2052-4897 (Print)
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 6
IP  - 1
DP  - 2018
TI  - Cardiac structure and function with and without metabolic syndrome: the 
      Echocardiographic Study of Latinos (Echo-SOL).
PG  - e000484
LID - 10.1136/bmjdrc-2017-000484 [doi]
LID - e000484
AB  - OBJECTIVE: We assessed the hypothesis that metabolic syndrome is associated with 
      adverse changes in cardiac structure and function in participants of the 
      Echocardiographic Study of Latinos (Echo-SOL). METHODS: Non-diabetic Echo-SOL 
      participants were included in this cross-sectional analysis. Metabolic syndrome 
      was defined according to the American Heart Association/National Heart, Lung, and 
      Blood Institute 2009 Joint Scientific Statement. Survey multivariable linear 
      regression analyses using sampling weights were used adjusting for multiple 
      potential confounding variables. Additional analysis was stratified according to 
      the presence/absence of obesity (body mass index (BMI) >/=25 kg/m(2)) and the 
      presence/absence of metabolic syndrome. RESULTS: Within Echo-SOL, 1260 
      individuals met inclusion criteria (59% female; mean age 55.2 years). Compared 
      with individuals without metabolic syndrome, those with metabolic syndrome had 
      lower medial and lateral E' velocities (-0.4 cm/s, (SE 0.1), p=0.0002; -0.5 cm/s 
      (0.2), p=0.02, respectively), greater E/E' (0.5(0.2), p=0.01) and worse 
      two-chamber left ventricular longitudinal strain (0.9%(0.3), p=0.009), after 
      adjusting for potential confounding variables. Increased left ventricular mass 
      index (9.8 g/m(2) (1.9), p<0.0001 and 7.5 g/m(2) (1.7), p<0.0001), left 
      ventricular end-diastolic volume (11.1 mL (3.0), p=0.0003 and 13.3 mL (2.7), 
      p<0.0001), left ventricular end-systolic volume (5.0 mL (1.4), p=0.0004 and 
      5.7 mL (1.3) p<0.0001) and left ventricular stroke volume (10.2 mL (1.8), 
      p<0.0001 and 13.0 mL (2.0), p<0.0001) were observed in obese individuals with and 
      without metabolic syndrome compared with individuals with normal weight without 
      metabolic syndrome. In sensitivity analyses, individuals with normal weight (BMI 
      <25 kg/m(2)) and metabolic syndrome had worse left ventricular global 
      longitudinal strain (2.1%(0.7), p=0.002) and reduced left ventricular ejection 
      fraction (-3.5%(1.4), p=0.007) compared with normal-weight individuals without 
      metabolic syndrome. CONCLUSIONS: In a sample of US Hispanics/Latinos metabolic 
      syndrome was associated with worse left ventricular systolic and diastolic 
      function. Adverse changes in left ventricular size and function were observed in 
      obese individuals with and without metabolic syndrome but decreased left 
      ventricular function was also present in normal-weight individuals with metabolic 
      syndrome.
FAU - Burroughs Pena, Melissa
AU  - Burroughs Pena M
AD  - Stanford Health Care, Oakland, California, USA.
FAU - Swett, Katrina
AU  - Swett K
AD  - Department of Epidemiology and Prevention, Wake Forest School of Medicine, 
      Winston-Salem, North Carolina, USA.
FAU - Schneiderman, Neil
AU  - Schneiderman N
AD  - Department of Psychology, Miller School of Medicine, University of Miami, Miami, 
      Florida, USA.
FAU - Spevack, Daniel M
AU  - Spevack DM
AD  - Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York, 
      USA.
FAU - Ponce, Sonia G
AU  - Ponce SG
AD  - Department of Family and Preventive Medicine, University of California, San 
      Diego, California, USA.
FAU - Talavera, Gregory A
AU  - Talavera GA
AD  - Division of Health Promotion and Behavioral Science, Graduate School of Public 
      Health, San Diego State University, San Diego, California, USA.
FAU - Kansal, Mayank M
AU  - Kansal MM
AD  - Division of Cardiology, University of Illinois, Chicago, Illinois, USA.
FAU - Daviglus, Martha L
AU  - Daviglus ML
AD  - Institute for Minority Health Research, University of Illinois, Chapel Hill, USA.
FAU - Cai, Jianwen
AU  - Cai J
AD  - Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel 
      Hill, North Carolina, USA.
FAU - Hurwitz, Barry E
AU  - Hurwitz BE
AD  - Department of Psychology, Miller School of Medicine, University of Miami, Miami, 
      Florida, USA.
FAU - Llabre, Maria M
AU  - Llabre MM
AD  - Department of Psychology, Miller School of Medicine, University of Miami, Miami, 
      Florida, USA.
FAU - Rodriguez, Carlos J
AU  - Rodriguez CJ
AD  - Department of Epidemiology and Prevention, Wake Forest School of Medicine, 
      Winston-Salem, North Carolina, USA.
LA  - eng
GR  - R01 HL104199/HL/NHLBI NIH HHS/United States
GR  - N01HC65236/HL/NHLBI NIH HHS/United States
GR  - N01HC65235/HL/NHLBI NIH HHS/United States
GR  - N01HC65234/HL/NHLBI NIH HHS/United States
GR  - P30 DK111022/DK/NIDDK NIH HHS/United States
GR  - N01HC65233/HL/NHLBI NIH HHS/United States
GR  - N01HC65237/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180813
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
PMC - PMC6091897
OTO - NOTNLM
OT  - echocardiography
OT  - hispanics
OT  - metabolic syndrome
OT  - obesity
COIS- Competing interests: None declared.
EDAT- 2018/08/18 06:00
MHDA- 2018/08/18 06:01
PMCR- 2018/08/13
CRDT- 2018/08/18 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2018/04/11 00:00 [revised]
PHST- 2018/04/19 00:00 [accepted]
PHST- 2018/08/18 06:00 [entrez]
PHST- 2018/08/18 06:00 [pubmed]
PHST- 2018/08/18 06:01 [medline]
PHST- 2018/08/13 00:00 [pmc-release]
AID - bmjdrc-2017-000484 [pii]
AID - 10.1136/bmjdrc-2017-000484 [doi]
PST - epublish
SO  - BMJ Open Diabetes Res Care. 2018 Aug 13;6(1):e000484. doi: 
      10.1136/bmjdrc-2017-000484. eCollection 2018.