PMID- 30117106
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20200225
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 56
IP  - 5
DP  - 2019 May
TI  - Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation.
PG  - 3295-3312
LID - 10.1007/s12035-018-1283-6 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins 
      in the healthy and diseased brain. As a result, there is a large body of evidence 
      that associates BDNF with neuronal maintenance, neuronal survival, plasticity, 
      and neurotransmitter regulation. Patients with psychiatric and neurodegenerative 
      disorders often have reduced BDNF concentrations in their blood and brain. A 
      current hypothesis suggests that these abnormal BDNF levels might be due to the 
      chronic inflammatory state of the brain in certain disorders, as 
      neuroinflammation is known to affect several BDNF-related signaling pathways. 
      Activation of glia cells can induce an increase in the levels of pro- and 
      antiinflammatory cytokines and reactive oxygen species, which can lead to the 
      modulation of neuronal function and neurotoxicity observed in several brain 
      pathologies. Understanding how neuroinflammation is involved in disorders of the 
      brain, especially in the disease onset and progression, can be crucial for the 
      development of new strategies of treatment. Despite the increasing evidence for 
      the involvement of BDNF and neuroinflammation in brain disorders, there is scarce 
      evidence that addresses the interaction between the neurotrophin and 
      neuroinflammation in psychiatric and neurodegenerative diseases. This review 
      focuses on the effect of acute and chronic inflammation on BDNF levels in the 
      most common psychiatric and neurodegenerative disorders and aims to shed some 
      light on the possible biological mechanisms that may influence this effect. In 
      addition, this review will address the effect of behavior and pharmacological 
      interventions on BDNF levels in these disorders.
FAU - Lima Giacobbo, Bruno
AU  - Lima Giacobbo B
AD  - Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, 
      Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av. 6681, Porto 
      Alegre, 90619-900, Brazil.
AD  - Department of Nuclear Medicine and Molecular Imaging, University of Groningen, 
      University Medical Center Groningen, Hanzeplein 1, P.O. Box 31.001, 9713 GZ, 
      Groningen, The Netherlands.
FAU - Doorduin, Janine
AU  - Doorduin J
AD  - Department of Nuclear Medicine and Molecular Imaging, University of Groningen, 
      University Medical Center Groningen, Hanzeplein 1, P.O. Box 31.001, 9713 GZ, 
      Groningen, The Netherlands.
FAU - Klein, Hans C
AU  - Klein HC
AD  - Department of Nuclear Medicine and Molecular Imaging, University of Groningen, 
      University Medical Center Groningen, Hanzeplein 1, P.O. Box 31.001, 9713 GZ, 
      Groningen, The Netherlands.
FAU - Dierckx, Rudi A J O
AU  - Dierckx RAJO
AD  - Department of Nuclear Medicine and Molecular Imaging, University of Groningen, 
      University Medical Center Groningen, Hanzeplein 1, P.O. Box 31.001, 9713 GZ, 
      Groningen, The Netherlands.
FAU - Bromberg, Elke
AU  - Bromberg E
AD  - Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, 
      Pontifical Catholic University of Rio Grande do Sul, Ipiranga Av. 6681, Porto 
      Alegre, 90619-900, Brazil.
FAU - de Vries, Erik F J
AU  - de Vries EFJ
AUID- ORCID: 0000-0002-6915-1590
AD  - Department of Nuclear Medicine and Molecular Imaging, University of Groningen, 
      University Medical Center Groningen, Hanzeplein 1, P.O. Box 31.001, 9713 GZ, 
      Groningen, The Netherlands. e.f.j.de.vries@umcg.nl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180817
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
MH  - Aging/pathology
MH  - Animals
MH  - Brain/pathology
MH  - Brain Diseases/*metabolism/*pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism/therapeutic use
MH  - Humans
MH  - Inflammation/*pathology
MH  - Models, Biological
PMC - PMC6476855
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Neuroinflammation
OT  - Neurological disorders
OT  - Neurotoxicity
EDAT- 2018/08/18 06:00
MHDA- 2019/08/21 06:00
PMCR- 2018/08/17
CRDT- 2018/08/18 06:00
PHST- 2018/03/08 00:00 [received]
PHST- 2018/07/24 00:00 [accepted]
PHST- 2018/08/18 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PHST- 2018/08/18 06:00 [entrez]
PHST- 2018/08/17 00:00 [pmc-release]
AID - 10.1007/s12035-018-1283-6 [pii]
AID - 1283 [pii]
AID - 10.1007/s12035-018-1283-6 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2019 May;56(5):3295-3312. doi: 10.1007/s12035-018-1283-6. Epub 
      2018 Aug 17.