PMID- 30118569
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20190221
IS  - 1708-8208 (Electronic)
IS  - 1523-0899 (Linking)
VI  - 20
IP  - 5
DP  - 2018 Oct
TI  - Regenerative surgical treatment of peri-implantitis using either a collagen 
      membrane or concentrated growth factor: A 12-month randomized clinical trial.
PG  - 703-712
LID - 10.1111/cid.12661 [doi]
AB  - BACKGROUND: Platelet concentration based membranes, as well as collagen membranes 
      in combination with bone substitutes, have demonstrated successful outcomes in 
      regeneration of peri-implant bone defects (PBD). PURPOSE: The aim of this study 
      was to evaluate the clinical and radiographic outcomes of regenerative surgical 
      treatment (RST) of peri-implantitis using a bone substitute combined with two 
      different bioresorbable barrier membranes, either collagen membrane (CM) or 
      concentrated growth factor (CGF), during 12-month follow-up. MATERIALS AND 
      METHODS: Fifty two patients, who had at least one peri-implantitis lesion was 
      treated by using a bone substitute in combination with CGF or CM. After surgical 
      procedures, implants were allowed for submerged healing. Clinical assessments 
      were conducted at baseline, 6 and 12 months postoperatively, while radiographic 
      evaluation was performed at baseline and 12 months. RESULTS: Significant 
      reductions were obtained in the mean gingival index (GI), bleeding on probing 
      (BOP), probing depth (PD), clinical attachment level (CAL) and mucosal recession 
      (MR) values at both 6 and 12 months postoperatively compared to baseline for both 
      treatment procedures (P < 0.05). At 6 months, no statistically significant 
      difference was observed for all clinical parameters between the groups, whereas 
      the mean PD, CAL and vertical defect depth (VDD) values were statistically 
      significant in favor of the CM group at 12 months (P < 0.05). The mean defect 
      fill (DF) in the CM group (1.99 +/-0.76) was not statistically significantly 
      different from that observed in the CCF group (1.63 +/-1.00) (P = 0.154). 
      CONCLUSIONS: The outcomes of the present study suggest that both regenerative 
      approaches yielded significant improvements in both clinical and radiographic 
      assessments. The procedure using a collagen membrane in combination with a bone 
      substitute showed better results at 12 months in RST of peri-implantitis.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Isler, Sila Cagri
AU  - Isler SC
AUID- ORCID: 0000-0001-5419-9658
AD  - Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, 
      Turkey.
FAU - Soysal, Fatma
AU  - Soysal F
AD  - Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, 
      Turkey.
FAU - Ceyhanli, Tugce
AU  - Ceyhanli T
AD  - Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, 
      Turkey.
FAU - Bakirarar, Batuhan
AU  - Bakirarar B
AD  - Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, 
      Turkey.
FAU - Unsal, Berrin
AU  - Unsal B
AD  - Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180817
PL  - United States
TA  - Clin Implant Dent Relat Res
JT  - Clinical implant dentistry and related research
JID - 100888977
RN  - 0 (Bone Substitutes)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membranes, Artificial)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Bone Substitutes/therapeutic use
MH  - Collagen/*therapeutic use
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*therapeutic use
MH  - Male
MH  - Membranes, Artificial
MH  - Middle Aged
MH  - Peri-Implantitis/diagnostic imaging/*surgery
MH  - Periodontal Attachment Loss
MH  - Periodontal Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - barrier membranes
OT  - collagen
OT  - concentrated growth factor
OT  - guided bone regeneration
OT  - peri-implant defect
OT  - peri-implantitis
EDAT- 2018/08/18 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/08/18 06:00
PHST- 2018/04/06 00:00 [received]
PHST- 2018/06/17 00:00 [revised]
PHST- 2018/07/10 00:00 [accepted]
PHST- 2018/08/18 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/08/18 06:00 [entrez]
AID - 10.1111/cid.12661 [doi]
PST - ppublish
SO  - Clin Implant Dent Relat Res. 2018 Oct;20(5):703-712. doi: 10.1111/cid.12661. Epub 
      2018 Aug 17.