PMID- 30119146
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1303-6165 (Electronic)
IS  - 1300-0144 (Linking)
VI  - 48
IP  - 4
DP  - 2018 Aug 16
TI  - Relationship of serum HLA-B alleles and TNF-alpha with rheumatic heart disease.
PG  - 724-729
LID - 10.3906/sag-1707-58 [doi]
AB  - BACKGROUND/AIM: Acute rheumatic fever and rheumatic heart disease are major 
      causes of morbidity and mortality in developing countries. Genetic studies have 
      determined that the immune response in rheumatic heart disease is genetically 
      controlled and that there is a close relationship between the gene of concern and 
      the class II human leukocyte antigen (HLA) gene. The aim of this study was to 
      evaluate the relationship of serum HLA-B alleles and tumor necrosis factor alpha 
      (TNF-alpha) with rheumatic heart disease. MATERIALS AND METHODS: A total of 50 
      consecutive patients with rheumatic heart disease and 50 controls were enrolled 
      in the study. HLA alleles were analyzed using sequence-specific primer-polymerase 
      chain reaction and nucleotide sequencing. RESULTS: The HLA-B35 allele was 
      significantly more common in patients with rheumatic heart disease than the 
      control group (P = 0.043). The HLA-B44 allele was significantly more common in 
      control patients than in patients with rheumatic heart disease (P = 0.014). There 
      was a significant inverse correlation between high-sensitivity C-reactive protein 
      and mitral valve area (P = 0.001). There was no correlation between TNF-alpha levels 
      and mitral valve area (P = 0.066). CONCLUSION: Our findings confirmed the 
      association between HLA-B alleles and rheumatic heart disease.
FAU - Eyiol, Azmi
AU  - Eyiol A
AUID- ORCID: 0000-0003-2740-1966
FAU - Yayla, Cagri
AU  - Yayla C
AUID- ORCID: 0000-0002-5302-4052
FAU - Unlu, Serkan
AU  - Unlu S
AUID- ORCID: 0000-0001-6179-8579
FAU - Tufan, Abdurrahman
AU  - Tufan A
AUID- ORCID: 0000-0001-6244-9362
FAU - Cemri, Mustafa
AU  - Cemri M
AUID- ORCID: 0000-0002-8259-5970
FAU - Yalcin, Ridvan
AU  - Yalcin R
AUID- ORCID: 0000-0001-5585-1505
FAU - Boyaci, Bulent
AU  - Boyaci B
AUID- ORCID: 0000-0002-3807-2021
LA  - eng
PT  - Journal Article
DEP - 20180816
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 0 (HLA-B Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Base Sequence
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - *Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - HLA-B Antigens/blood/*genetics
MH  - Humans
MH  - Male
MH  - Mitral Valve
MH  - Polymerase Chain Reaction
MH  - Rheumatic Heart Disease/blood/*genetics
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - *Rheumatic heart disease
OT  - *human leukocyte antigen B subgroups
OT  - *tumor necrosis factor alpha
EDAT- 2018/08/18 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/08/18 06:00
PHST- 2018/08/18 06:00 [entrez]
PHST- 2018/08/18 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
AID - 10.3906/sag-1707-58 [doi]
PST - epublish
SO  - Turk J Med Sci. 2018 Aug 16;48(4):724-729. doi: 10.3906/sag-1707-58.