PMID- 30120813
OWN - NLM
STAT- MEDLINE
DCOM- 20190321
LR  - 20200225
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jan
TI  - Impaired social contacts with familiar anesthetized conspecific in CA3-restricted 
      brain-derived neurotrophic factor knockout mice.
PG  - e12513
LID - 10.1111/gbb.12513 [doi]
AB  - Familiarity is conveyed by social cues and determines behaviors toward 
      conspecifics. Here, we characterize a novel assay for social behaviors in 
      mice-contacts with anesthetized conspecific-which eliminates reciprocal 
      interactions, including intermale aggression and shows behaviors that are 
      independent of the demonstrator's activity. During the initial 10 minutes 
      (phase-1), the wild-type (WT) subjects contacted the anesthetized conspecifics 
      vigorously regardless of familiarity. During the subsequent 80 minutes (phase-2), 
      however, they contacted more with familiar than unfamiliar conspecifics. We then 
      applied this test to highly aggressive mice with a hippocampal CA3-restricted 
      knockout (KO) of brain-derived neurotrophic factor (BDNF), in which aggression 
      may mask other social behaviors. The KO mice showed less preference for 
      contacting familiar conspecifics than did WT mice during phase-2 but no 
      differences during phase-1. Among nonsocial behaviors, WT mice also spent less 
      time eating in the presence of familiar than with unfamiliar conspecifics, which 
      was not seen in KO mice. In addition, KO mice exhibited reduced pain 
      sensitization. Altogether, these findings suggest that CA3-specific deletion of 
      BDNF results in deficits in circuits that process social cues from familiar 
      conspecifics as well as pain and may underlie empathy-like behaviors.
CI  - (c) 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics 
      Society.
FAU - Ito, Wataru
AU  - Ito W
AD  - Virginia Tech Carilion Research Institute, Roanoke, Virginia.
FAU - Huang, Howard
AU  - Huang H
AD  - Virginia Tech Carilion Research Institute, Roanoke, Virginia.
FAU - Brayman, Vanessa
AU  - Brayman V
AD  - Virginia Tech Carilion Research Institute, Roanoke, Virginia.
AD  - Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, 
      Blacksburg, Virginia.
FAU - Morozov, Alexei
AU  - Morozov A
AUID- ORCID: 0000-0003-0495-3987
AD  - Virginia Tech Carilion Research Institute, Roanoke, Virginia.
AD  - School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, 
      Virginia.
AD  - Department of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School 
      of Medicine, Roanoke, Virginia.
LA  - eng
GR  - K22 MH097826/MH/NIMH NIH HHS/United States
GR  - K22MH097826/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180904
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Aggression
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - CA3 Region, Hippocampal/*metabolism/physiology
MH  - Feeding Behavior
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pain Threshold
PMC - PMC6342662
MID - NIHMS986524
OTO - NOTNLM
OT  - BDNF knockout
OT  - anesthetized conspecific
OT  - empathy
OT  - pain
OT  - social interaction
COIS- Competing interests Authors declare no competing interests.
EDAT- 2018/08/19 06:00
MHDA- 2019/03/22 06:00
PMCR- 2020/01/01
CRDT- 2018/08/19 06:00
PHST- 2017/08/18 00:00 [received]
PHST- 2018/07/20 00:00 [revised]
PHST- 2018/08/14 00:00 [accepted]
PHST- 2018/08/19 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
PHST- 2018/08/19 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.1111/gbb.12513 [doi]
PST - ppublish
SO  - Genes Brain Behav. 2019 Jan;18(1):e12513. doi: 10.1111/gbb.12513. Epub 2018 Sep 
      4.