PMID- 30121183
OWN - NLM
STAT- MEDLINE
DCOM- 20200303
LR  - 20200309
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 204
DP  - 2019 Feb
TI  - Social vs. non-social measures of learning potential for predicting community 
      functioning across phase of illness in schizophrenia.
PG  - 104-110
LID - S0920-9964(18)30492-4 [pii]
LID - 10.1016/j.schres.2018.07.046 [doi]
AB  - Studies demonstrate that dynamic assessment (i.e., learning potential) improves 
      the prediction of response to rehabilitation over static measures in individuals 
      with schizophrenia. Learning potential is most commonly assessed using 
      neuropsychological tests under a test-train-test paradigm to examine change in 
      performance. Novel learning potential approaches using social cognitive tasks may 
      have added value, particularly for the prediction of social functioning, but this 
      area is unexplored. The present study is the first to investigate whether 
      patients with schizophrenia demonstrate social cognitive learning potential 
      across phase of illness. This study included 43 participants at clinical high 
      risk (CHR), 63 first-episode, and 36 chronic schizophrenia patients. Assessment 
      of learning potential involved test-train-test versions of the Wisconsin Card 
      Sorting Test (non-social cognitive learning potential) and the Facial Emotion 
      Identification Test (social cognitive learning potential). Non-social and social 
      cognition pre-training scores (static scores) uniquely predicted concurrent 
      community functioning in patients with schizophrenia, but not in CHR 
      participants. Learning potential showed no incremental explanation of variance 
      beyond static scores. First-episode patients showed larger non-social cognitive 
      learning potential than CHR participants and were similar to chronic patients; 
      chronic patients and CHR participants were similar. Group differences across 
      phase of illness were not observed for social cognitive learning potential. 
      Subsequent research could explore whether non-social and social cognitive 
      learning potential relate differentially to non-social versus social types of 
      training and rehabilitation.
CI  - Published by Elsevier B.V.
FAU - Clayson, Peter E
AU  - Clayson PE
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United 
      States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School 
      of Medicine, University of California Los Angeles, Los Angeles, CA, United 
      States. Electronic address: pclayson@ucla.edu.
FAU - Kern, Robert S
AU  - Kern RS
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United 
      States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School 
      of Medicine, University of California Los Angeles, Los Angeles, CA, United 
      States.
FAU - Nuechterlein, Keith H
AU  - Nuechterlein KH
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States; 
      Department of Psychology, University of California Los Angeles, Los Angeles, CA, 
      United States.
FAU - Knowlton, Barbara J
AU  - Knowlton BJ
AD  - Department of Psychology, University of California Los Angeles, Los Angeles, CA, 
      United States.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States; 
      Department of Psychology, University of California Los Angeles, Los Angeles, CA, 
      United States.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT, United States.
FAU - Fiske, Alan P
AU  - Fiske AP
AD  - Department of Anthropology, University of California Los Angeles, Los Angeles, 
      CA, United States.
FAU - Ghermezi, Livon
AU  - Ghermezi L
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States.
FAU - Hayata, Jacqueline N
AU  - Hayata JN
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States.
FAU - Hellemann, Gerhard S
AU  - Hellemann GS
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States.
FAU - Horan, William P
AU  - Horan WP
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United 
      States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School 
      of Medicine, University of California Los Angeles, Los Angeles, CA, United 
      States.
FAU - Kee, Kimmy
AU  - Kee K
AD  - Department of Psychology, California State University Channel Islands, Los 
      Angeles, CA, United States.
FAU - Lee, Junghee
AU  - Lee J
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United 
      States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School 
      of Medicine, University of California Los Angeles, Los Angeles, CA, United 
      States.
FAU - Subotnik, Kenneth L
AU  - Subotnik KL
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States.
FAU - Sugar, Catherine A
AU  - Sugar CA
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States.
FAU - Ventura, Joseph
AU  - Ventura J
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States.
FAU - Yee, Cindy M
AU  - Yee CM
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA, United States; 
      Department of Psychology, University of California Los Angeles, Los Angeles, CA, 
      United States.
FAU - Green, Michael F
AU  - Green MF
AD  - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United 
      States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School 
      of Medicine, University of California Los Angeles, Los Angeles, CA, United 
      States.
LA  - eng
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180816
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chronic Disease
MH  - Cognitive Dysfunction/diagnosis/etiology/*physiopathology
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Learning/*physiology
MH  - Male
MH  - Risk
MH  - Schizophrenia/complications/*physiopathology
MH  - *Social Perception
MH  - Young Adult
PMC - PMC6377348
MID - NIHMS1503974
OTO - NOTNLM
OT  - Dynamic assessment
OT  - FEIT
OT  - Learning potential
OT  - Schizophrenia
OT  - Social cognition
OT  - WCST
COIS- Conflicts of Interest T.D.C. reports that he is a consultant to the Los Angeles 
      Department of Mental Health and to Boehringer Ingelheim Pharmaceuticals. M.F.G. 
      has been a consultant to AbbVie, ACADIA, DSP, and Takeda, is on the scientific 
      advisory board of Luc, and has received unrelated research funds from FORUM. 
      K.H.N. has been a consultant to Astellas, Genentech, Janssen, Medincell, Otsuka, 
      Takeda, and Teva, and he has received unrelated research grants from Genentech, 
      Janssen Scientific Affairs and Posit Science. K.L.S. has served as a consultant 
      to Janssen Scientific Affairs, LLC, has been on the speaker's bureau for Otsuka 
      America Pharmaceutical, Inc., and has received research support from Genentech, 
      Inc., and Janssen Scientific Affairs, LLC through grants to K.H.N. and J.V. J.V. 
      has received funding from Brain Plasticity, Inc., Genentech, Inc., and Janssen 
      Scientific Affairs, LLC, and has served as a consultant to Boehringer-Ingelheim, 
      GmbH, and Brain Plasticity, Inc. All the other authors do not have any conflict 
      of interest.
EDAT- 2018/08/20 06:00
MHDA- 2020/03/04 06:00
PMCR- 2020/02/01
CRDT- 2018/08/20 06:00
PHST- 2018/05/01 00:00 [received]
PHST- 2018/07/27 00:00 [revised]
PHST- 2018/07/31 00:00 [accepted]
PHST- 2018/08/20 06:00 [pubmed]
PHST- 2020/03/04 06:00 [medline]
PHST- 2018/08/20 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - S0920-9964(18)30492-4 [pii]
AID - 10.1016/j.schres.2018.07.046 [doi]
PST - ppublish
SO  - Schizophr Res. 2019 Feb;204:104-110. doi: 10.1016/j.schres.2018.07.046. Epub 2018 
      Aug 16.