PMID- 30121663
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20190212
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 48
IP  - 6
DP  - 2018
TI  - Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and 
      Neuronal Structural Plasticity in Rats.
PG  - 2470-2482
LID - 10.1159/000492684 [doi]
AB  - BACKGROUND/AIMS: Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective 
      effects in various studies. This study aimed to investigate the neuronal 
      mechanisms underlying the neuroprotective and antidepressant-like effects of 
      ginsenoside Rg1 in a rat model of depression. METHODS: Chronic unpredictable mild 
      stress was used to induce depression-like behaviors in rats. Transmission 
      electron microscopy was used to observe neuronal synapses within the basolateral 
      amygdala (BLA). The expression of microRNA (miR)-134 in the BLA was verified by 
      real-time quantitative PCR. Finally, the synaptic plasticity-associated proteins 
      CAMP-response element binding protein (CREB) and brain-derived neurotrophic 
      factor (BDNF) were detected by immunoblotting. RESULTS: Results showed that 
      chronic stress effectively induced depression-like behaviors in rats, which were 
      associated with significant ultrastructural changes within BLA neurons. Moreover, 
      chronic stress decreased the expression of miR-134 in the BLA, which was 
      accompanied by decreased phosphorylation of CREB and decreased expression of 
      BDNF. Remarkably, chronic administration of ginsenoside Rg1 (40 mg/kg, i.p., 5 
      weeks) significantly ameliorated the neuronal structural abnormalities and 
      biochemical changes induced by chronic stress, as well as preventing 
      depression-like behaviors in these rats. CONCLUSION: Results suggested that 
      ginsenoside Rg1 may exhibit neuroprotection and antidepressant-like effects by 
      activating the CREB-BDNF system within the BLA in this rat model of depression. 
      Amelioration of depression-like behaviors by ginsenoside Rg1 appears to involve 
      modulation of the synapse-associated factor miR-134 within the BLA. Therefore, 
      these findings demonstrate some of the neuronal mechanisms associated with 
      depression and the therapeutic potential of ginsenoside Rg1 for use in the 
      treatment of depression in clinical trials.
CI  - (c) 2018 The Author(s). Published by S. Karger AG, Basel.
FAU - Yu, Hongluan
AU  - Yu H
AD  - Department of Psychiatry, Qilu Hospital of Shandong University, Jinan, China.
FAU - Fan, Cuiqin
AU  - Fan C
AD  - Department of Physiology, Shandong University, School of Medicine, Jinan, China.
FAU - Yang, Lejin
AU  - Yang L
AD  - Department of Psychiatry, Qilu Hospital of Shandong University, Jinan, China.
FAU - Yu, Shuyan
AU  - Yu S
AD  - Department of Physiology, Shandong University, School of Medicine, Jinan, China.
FAU - Song, Qiqi
AU  - Song Q
AD  - Department of Physiology, Shandong University, School of Medicine, Jinan, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Physiology, Shandong University, School of Medicine, Jinan, China.
FAU - Mao, Xueqin
AU  - Mao X
AD  - Department of Psychiatry, Qilu Hospital of Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
DEP - 20180817
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (Ginsenosides)
RN  - 0 (MIRN134 microRNA, rat)
RN  - 0 (MicroRNAs)
RN  - PJ788634QY (ginsenoside Rg1)
SB  - IM
MH  - Animals
MH  - Basolateral Nuclear Complex/drug effects/*metabolism/ultrastructure
MH  - Behavior, Animal/*drug effects
MH  - Depressive Disorder/pathology/prevention & control
MH  - Disease Models, Animal
MH  - Ginsenosides/*pharmacology/therapeutic use
MH  - Locomotion/drug effects
MH  - Male
MH  - MicroRNAs/metabolism
MH  - Microscopy, Electron, Transmission
MH  - Neuronal Plasticity/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - *Stress, Physiological
OTO - NOTNLM
OT  - BDNF
OT  - Chronic unpredictable mild stress
OT  - Ginsenoside Rg1
OT  - MiR-134
OT  - Structural plasticity
EDAT- 2018/08/20 06:00
MHDA- 2018/09/11 06:00
CRDT- 2018/08/20 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/08/20 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2018/08/20 06:00 [entrez]
AID - 000492684 [pii]
AID - 10.1159/000492684 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2018;48(6):2470-2482. doi: 10.1159/000492684. Epub 2018 Aug 
      17.