PMID- 30122875
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181114
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 24
IP  - 30
DP  - 2018 Aug 14
TI  - Host genetic factors affecting hepatitis B infection outcomes: Insights from 
      genome-wide association studies.
PG  - 3347-3360
LID - 10.3748/wjg.v24.i30.3347 [doi]
AB  - The clinical outcome of hepatitis B virus (HBV) infection depends on the success 
      or failure of the immune responses to HBV, and varies widely among individuals, 
      ranging from asymptomatic self-limited infection, inactive carrier state, chronic 
      hepatitis, cirrhosis, hepatocellular carcinoma, to liver failure, depending on 
      the success or failure of immune response to HBV. Genome-wide association studies 
      (GWAS) identified key genetic factors influencing the pathogenesis of HBV-related 
      traits. In this review, we discuss GWAS for persistence of HBV infection, 
      antibody response to hepatitis B vaccine, and HBV-related advanced liver 
      diseases. HBV persistence is associated with multiple genes with diverse roles in 
      immune mechanisms. The strongest associations are found within the classical 
      human leukocyte antigen (HLA) genes, highlighting the central role of antigen 
      presentation in the immune response to HBV. Associated variants affect both 
      epitope binding specificities and expression levels of HLA molecules. Several 
      other susceptibility genes regulate the magnitude of adaptive immune responses, 
      determining immunity vs tolerance. HBV persistence and nonresponse to vaccine 
      share the same risk variants, implying overlapping genetic bases. On the other 
      hand, the risk variants for HBV-related advanced liver diseases are largely 
      different, suggesting different host-virus dynamics in acute vs chronic HBV 
      infections. The findings of these GWAS are likely to pave the way for developing 
      more effective preventive and therapeutic interventions by personalizing the 
      management of HBV infection.
FAU - Akcay, Izzet Mehmet
AU  - Akcay IM
AD  - Department of Molecular Biology and Genetics, Istanbul Technical University, 
      Istanbul 34469, Turkey.
FAU - Katrinli, Seyma
AU  - Katrinli S
AD  - Department of Molecular Biology and Genetics, Istanbul Technical University, 
      Istanbul 34469, Turkey.
FAU - Ozdil, Kamil
AU  - Ozdil K
AD  - Department of Gastroenterology and Hepatology, Umraniye Teaching and Research 
      Hospital, Istanbul 34764, Turkey.
FAU - Doganay, Gizem Dinler
AU  - Doganay GD
AD  - Department of Molecular Biology and Genetics, Istanbul Technical University, 
      Istanbul 34469, Turkey.
FAU - Doganay, Levent
AU  - Doganay L
AD  - Department of Gastroenterology and Hepatology, Umraniye Teaching and Research 
      Hospital, Istanbul 34764, Turkey. levent.doganay@saglik.gov.tr.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Alleles
MH  - Antigen Presentation/genetics/immunology
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA Antigens/*genetics/immunology
MH  - Hepatitis B/*genetics/immunology/therapy/virology
MH  - Hepatitis B Vaccines/immunology/*therapeutic use
MH  - Hepatitis B virus/*immunology
MH  - Humans
MH  - Immunogenicity, Vaccine/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Precision Medicine/methods
PMC - PMC6092584
OTO - NOTNLM
OT  - Antigen presentation
OT  - Cirrhosis
OT  - Genome-wide association studies
OT  - Hepatitis B infection
OT  - Hepatocellular carcinoma
OT  - Immune response to hepatitis B virus
COIS- Conflict-of-interest statement: We declare no potential conflict of interests.
EDAT- 2018/08/21 06:00
MHDA- 2018/11/10 06:00
PMCR- 2018/08/14
CRDT- 2018/08/21 06:00
PHST- 2018/04/09 00:00 [received]
PHST- 2018/05/29 00:00 [revised]
PHST- 2018/06/25 00:00 [accepted]
PHST- 2018/08/21 06:00 [entrez]
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
PHST- 2018/08/14 00:00 [pmc-release]
AID - 10.3748/wjg.v24.i30.3347 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2018 Aug 14;24(30):3347-3360. doi: 
      10.3748/wjg.v24.i30.3347.