PMID- 30123046
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20230928
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 15
IP  - 11
DP  - 2018
TI  - The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult 
      Cardiovascular Diseases.
PG  - 1098-1104
LID - 10.7150/ijms.25857 [doi]
AB  - Background: The relationship of serum antigen-specific immunoglobulin E (IgE) 
      with cardiovascular diseases (CVDs) remains poorly understood. This study aimed 
      to explore the association of antigen-specific and total IgE with CVDs using data 
      derived from the National Health and Nutrition Examination Survey (NHANES) 
      2005-2006. Methods and Results: The association of serum total or 
      antigen-specific IgE levels with CVDs was analyzed by survey-weighted logistic 
      regression modeling, adjusted by age, sex, race, education, body mass index, 
      blood pressure, total cholesterol, C-reactive protein, homocysteine, diabetes, 
      smoking, and alcohol consumption. 4953 subjects were included. Coronary heart 
      disease was significantly related to serum total IgE levels. The association of 
      serum total IgE levels with coronary heart disease was further validated by 
      negative, >/=1 and 1-6 positive antigen-specific IgE. Myocardial infarction was 
      positively associated with serum total IgE levels only when all antigen-specific 
      IgE were negative, but inversely associated with serum total IgE when 
      plant-specific IgE test results were positive. More specifically, myocardial 
      infarction was also inversely related to positive oak, birch, or peanut-specific 
      IgE. In addition, serum total IgE are positively associated with angina when at 
      least one specific IgE were positive. Conclusions: Serum antigen-specific IgE, as 
      well as total IgE, is significantly associated with CVDs independently of a long 
      list of established cardiovascular risk factors, which is more informative than 
      total IgE per se.
FAU - Xu, Zhiyan
AU  - Xu Z
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Peking Union Medical College, Beijing, China.
AD  - Department of Anatomy, Histology and Embryology; Institute of Basic Medical 
      Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 
      Beijing, China.
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Guo, Xiaoxiao
AU  - Guo X
AD  - Department of Cardiology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Li, Yao
AU  - Li Y
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Peking Union Medical College, Beijing, China.
FAU - Hu, Yi
AU  - Hu Y
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, 
      Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese 
      Academy of Sciences (CAS), Beijing, China.
FAU - Ma, Chao
AU  - Ma C
AD  - Department of Anatomy, Histology and Embryology; Institute of Basic Medical 
      Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 
      Beijing, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20180701
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allergens
MH  - Cardiovascular Diseases/*blood
MH  - Child
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Young Adult
PMC - PMC6097256
OTO - NOTNLM
OT  - Antigen-specific IgE
OT  - Cardiovascular diseases
OT  - Immune system
OT  - Immunoglobulin E
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2018/08/21 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/01/01
CRDT- 2018/08/21 06:00
PHST- 2018/03/04 00:00 [received]
PHST- 2018/05/22 00:00 [accepted]
PHST- 2018/08/21 06:00 [entrez]
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ijmsv15p1098 [pii]
AID - 10.7150/ijms.25857 [doi]
PST - epublish
SO  - Int J Med Sci. 2018 Jul 1;15(11):1098-1104. doi: 10.7150/ijms.25857. eCollection 
      2018.