PMID- 30123216
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20221207
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Genetic Regulation of the Thymic Stromal Lymphopoietin (TSLP)/TSLP Receptor 
      (TSLPR) Gene Expression and Influence of Epistatic Interactions Between IL-33 and 
      the TSLP/TSLPR Axis on Risk of Coronary Artery Disease.
PG  - 1775
LID - 10.3389/fimmu.2018.01775 [doi]
LID - 1775
AB  - The thymic stromal lymphopoietin (TSLP)/TSLP receptor (TSLPR) axis is involved in 
      multiple inflammatory immune diseases, including coronary artery disease (CAD). 
      To explore the causal relationship between this axis and CAD, we performed a 
      three-stage case-control association analysis with 3,628 CAD cases and 3,776 
      controls using common variants in the genes TSLP, interleukin 7 receptor (IL7R), 
      and TSLPR. Three common variants in the TSLP/TSLPR axis were significantly 
      associated with CAD in a Chinese Han population [rs3806933(T) in TSLP, 
      P(adj) = 4.35 x 10(-5), odds ratio (OR) = 1.18; rs6897932(T) in IL7R, 
      P(adj) = 1.13 x 10(-7), OR = 1.31; g.19646A>G(A) in TSLPR, 
      P(adj) = 2.04 x 10(-6), OR = 1.20]. Reporter gene analysis demonstrated that 
      rs3806933 and rs6897932 could influence TSLP and IL7R expression, respectively. 
      Furthermore, the "T" allele of rs3806933 might increase plasma TSLP levels 
      (R(2) = 0.175, P < 0.01). In a stepwise procedure, the risk for CAD increased by 
      nearly fivefold compared with the maximum effect of any single variant 
      (P(adj) = 6.99 x 10(-4), OR = 4.85). In addition, the epistatic interaction 
      between TSLP and IL33 produced a nearly threefold increase in the risk of CAD in 
      the combined model of rs3806933(TT)-rs7025417(TT) (P(adj) = 3.67 x 10(-4), 
      OR = 2.98). Our study illustrates that the TSLP/TSLPR axis might be involved in 
      the pathogenesis of CAD through upregulation of mRNA or protein expression of the 
      referenced genes and might have additive effects on the CAD risk when combined 
      with IL-33 signaling.
FAU - Nie, Shao-Fang
AU  - Nie SF
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Zha, Ling-Feng
AU  - Zha LF
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
AD  - Innovation Institute, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Fan, Qian
AU  - Fan Q
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
AD  - Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Liao, Yu-Hua
AU  - Liao YH
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Zhang, Hong-Song
AU  - Zhang HS
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Chen, Qian-Wen
AU  - Chen QW
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Wang, Fan
AU  - Wang F
AD  - Department of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, 
      Cleveland, OH, United States.
FAU - Tang, Ting-Ting
AU  - Tang TT
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Xia, Ni
AU  - Xia N
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Xu, Cheng-Qi
AU  - Xu CQ
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Zhang, Jiao-Yue
AU  - Zhang JY
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Lu, Yu-Zhi
AU  - Lu YZ
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Zeng, Zhi-Peng
AU  - Zeng ZP
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Jiao, Jiao
AU  - Jiao J
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Li, Yuan-Yuan
AU  - Li YY
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Xie, Tian
AU  - Xie T
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Zhang, Wen-Juan
AU  - Zhang WJ
AD  - Department of Geriatrics, the Central Hospital of Wuhan, Tongji Medica College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Wang, Dan
AU  - Wang D
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Wang, Chu-Chu
AU  - Wang CC
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Fa, Jing-Jing
AU  - Fa JJ
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Xiong, Hong-Bo
AU  - Xiong HB
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Ye, Jian
AU  - Ye J
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Yang, Qing
AU  - Yang Q
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Wang, Peng-Yun
AU  - Wang PY
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Tian, Sheng-Hua
AU  - Tian SH
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Lv, Qiu-Lun
AU  - Lv QL
AD  - Section of Molecule Medicine, Department of Medicine, University of Oklahoma 
      Health Sciences Center, Oklahoma City, OK, United States.
FAU - Li, Qing-Xian
AU  - Li QX
AD  - Jining Medical College Affiliated Hospital, Jining, China.
FAU - Qian, Jin
AU  - Qian J
AD  - Suizhou Central Hospital, Suizhou, China.
FAU - Li, Bin
AU  - Li B
AD  - Xiangyang Central Hospital, Xiangyang, China.
FAU - Wu, Gang
AU  - Wu G
AD  - Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Wu, Yan-Xia
AU  - Wu YX
AD  - Wuhan No. 1 Hospital, Wuhan, China.
FAU - Yang, Yan
AU  - Yang Y
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Yang, Xiang-Ping
AU  - Yang XP
AD  - School of Basic Medicine, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Hu, Yu
AU  - Hu Y
AD  - Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Qing K
AU  - Wang QK
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Cheng, Xiang
AU  - Cheng X
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Key Laboratory for Biological Targeted Therapy of Education Ministry and Hubei 
      Province, Union Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Tu, Xin
AU  - Tu X
AD  - Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life 
      Science and Technology, Center for Human Genome Research, Cardio-X Institute, 
      Huazhong University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180803
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (CRLF2 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (IL33 protein, human)
RN  - 0 (Interleukin-33)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Interleukin-7)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Coronary Artery Disease/diagnosis/*etiology/*metabolism/mortality
MH  - Cytokines/blood/*genetics/metabolism
MH  - *Epistasis, Genetic
MH  - Female
MH  - *Gene Expression Regulation
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-33/*genetics/metabolism
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Proportional Hazards Models
MH  - Receptors, Cytokine/*genetics/metabolism
MH  - Receptors, Interleukin-7/genetics
MH  - Signal Transduction
MH  - Thymic Stromal Lymphopoietin
PMC - PMC6085432
OTO - NOTNLM
OT  - IL-33
OT  - coronary artery disease
OT  - epistatic
OT  - genetic regulation
OT  - thymic stromal lymphopoietin/TSLP receptor
EDAT- 2018/08/21 06:00
MHDA- 2019/09/17 06:00
PMCR- 2018/01/01
CRDT- 2018/08/21 06:00
PHST- 2018/03/21 00:00 [received]
PHST- 2018/07/18 00:00 [accepted]
PHST- 2018/08/21 06:00 [entrez]
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.01775 [doi]
PST - epublish
SO  - Front Immunol. 2018 Aug 3;9:1775. doi: 10.3389/fimmu.2018.01775. eCollection 
      2018.