PMID- 30124029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230702
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 35
IP  - 4
DP  - 2018 Aug 25
TI  - [Research progress of producing genetically modified pigs by CRISPR/Cas9 in the 
      medical field].
PG  - 637-642
LID - 10.7507/1001-5515.201802046 [doi]
AB  - As pigs are similar to humans in anatomy, physiology and pathology, nutrition 
      metabolism and disease characteristics, genetically modified pigs are already 
      used for the studies of disease mechanism, pathology and toxicology and the 
      evaluation of drugs. But the production of large modified animals is difficult, 
      cumbersome, time-consuming and costly. With the breakthrough of gene editing 
      technology, clustered regularly interspersed short palindromic repeat 
      (CRISPR)/CRISPR-associated 9( Cas9)(CRISPR/Cas9) technology has greatly improved 
      the mutation efficiency, reduced the cost and simplified the steps, and promoted 
      the widespread application of genetically modified pigs. In this paper, the 
      production methods of genetically modified pigs and the research progress of 
      genetically modified pigs by CRISPR/Cas9 in the medical field were reviewed.
FAU - Gao, Mengyu
AU  - Gao M
AD  - Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, 
      West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
FAU - Yang, Guang
AU  - Yang G
AD  - Experimental Animal Center, West China Hospital, Sichuan University, Chengdu 
      610041, P.R.China.
FAU - Bao, Ji
AU  - Bao J
AD  - Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, 
      West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
PMC - PMC9935125
OTO - NOTNLM
OT  - clustered regularly interspersed short palindromic repeat/CRISPR-associated 9
OT  - gene editing
OT  - genetically modified pig
OT  - large animal disease models
EDAT- 2018/08/21 06:00
MHDA- 2018/08/21 06:01
PMCR- 2018/08/01
CRDT- 2018/08/21 06:00
PHST- 2018/08/21 06:00 [entrez]
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2018/08/21 06:01 [medline]
PHST- 2018/08/01 00:00 [pmc-release]
AID - swyxgcxzz-35-4-637 [pii]
AID - 10.7507/1001-5515.201802046 [doi]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 Aug 25;35(4):637-642. doi: 
      10.7507/1001-5515.201802046.