PMID- 30124489
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20190725
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 18
IP  - 6
DP  - 2018 Dec
TI  - Role of allergen-specific T-follicular helper cells in immunotherapy.
PG  - 495-501
LID - 10.1097/ACI.0000000000000480 [doi]
AB  - PURPOSE OF REVIEW: The discovery of novel T-cell subsets including follicular 
      helper T (Tfh) cells has broadened our knowledge on the complex immune networks 
      in allergic diseases. This review summarizes the evidence for Tfh cells in 
      controlling immune responses to allergens with a particular focus on 
      immunoglobulin E (IgE) production and discusses the implication of such 
      regulation in allergen-specific immunotherapy. RECENT FINDINGS: Tfh cells support 
      the production of IgE in animal models for allergic diseases. Among Tfh cells, 
      the type 2 subset (Tfh2) is considered as the major player that secretes IL-4 and 
      promotes the isotype switching to IgE. In human inflammatory airway diseases, 
      including allergic rhinitis, asthma, and nasal polyps, the increased frequencies 
      of circulating or tissue Tfh2 cells have been reported. Notably, the frequencies 
      of Dermatophagoides pteronyssinus group 1 (Der p 1)-specific IL-4 Tfh cells in 
      blood positively correlated with serum Der p-specific IgE levels in allergic 
      rhinitis patients. After allergen immunotherapy (AIT), Der p 1-specific IL-4 Tfh 
      cells declined in allergic rhinitis patients, which associated with the remission 
      of clinical symptoms. SUMMARY: Allergen-specific IL-4 Tfh cells contribute to the 
      production of allergen-specific IgE and correlate with clinical efficacy of AIT 
      in allergic rhinitis patients, which suggest allergen-specific Tfh cells as a 
      promising therapeutic target and biomarker for AIT in allergic rhinitis.
FAU - Yao, Yin
AU  - Yao Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, People's 
      Republic of China.
FAU - Wang, Zhi-Chao
AU  - Wang ZC
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, People's 
      Republic of China.
FAU - Yu, Di
AU  - Yu D
AD  - Department of Immunology and Infectious Disease, John Curtin School of Medical 
      Research, Australian National University, Canberra, Australia.
FAU - Liu, Zheng
AU  - Liu Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - *Allergens/immunology/therapeutic use
MH  - Animals
MH  - *Antigens, Dermatophagoides/immunology/therapeutic use
MH  - *Asthma/immunology/pathology/therapy
MH  - *Desensitization, Immunologic
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - *Nasal Polyps/immunology/pathology/therapy
MH  - *T-Lymphocytes, Helper-Inducer/immunology/pathology
EDAT- 2018/08/21 06:00
MHDA- 2019/07/26 06:00
CRDT- 2018/08/21 06:00
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2018/08/21 06:00 [entrez]
AID - 10.1097/ACI.0000000000000480 [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2018 Dec;18(6):495-501. doi: 
      10.1097/ACI.0000000000000480.