PMID- 30125564
OWN - NLM
STAT- MEDLINE
DCOM- 20181227
LR  - 20181227
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 836
DP  - 2018 Oct 5
TI  - The dorsal hippocampal group III metabotropic glutamate receptors are involved in 
      morphine effect on memory formation in male mice.
PG  - 44-49
LID - S0014-2999(18)30476-X [pii]
LID - 10.1016/j.ejphar.2018.08.023 [doi]
AB  - This study investigated the role of dorsal hippocampal (CA1) group III 
      metabotropic glutamate (mGlu) receptors in impairment of memory formation and 
      state-dependent memory induced by morphine. For this purpose, the CA1 area was 
      cannulated and one-trial passive avoidance task was selected to assess the memory 
      function. Morphine was administrated subcutaneously (s.c.) and mGlu receptors 
      agonist or antagonist were microinjected into CA1 regions. The obtained results 
      indicated that pre-training administration of morphine (5 mg/kg; s.c.) decreased 
      memory retention. Moreover, pre-test administration of morphine (5 mg/kg; s.c.) 
      induced morphine state-dependent memory retention under pre-training morphine 
      effect (5 mg/kg; s.c.). Although, intra-CA1 microinjection of lower doses of 
      group III mGlu receptors agonist, L-AP4, (10 and 20 mmol/mouse) and antagonist, 
      CPPG, (10 and 15 mmol/mouse) did not affect memory retention, but higher dose of 
      the drugs (30 mmol/mouse) decreased memory retention. Pre-test microinjection of 
      L-AP4 (10, 20 and 30 mmol/mouse; intra-CA1) had no effect on morphine-induced 
      amnesia, but same doses of L-AP4 plus an effective dose of morphine (1 mg/kg; 
      s.c.) reversed morphine-induced amnesia. Interestingly, amnesia induced by 
      pre-training morphine (5 mg/kg; s.c.) was significantly reversed by pre-test 
      administration of CPPG (30 mmol/mouse; intra-CA1). On the other hand, pre-test 
      co-administration of CPPG (10 and 15 mmol/mouse; intra-CA1) and morphine 
      (5 mg/kg; s.c.) following pre-training morphine (5 mg/kg; s.c.) decreased memory 
      retention. Taken together, our results suggested that morphine effects on memory 
      formation might be mediated via the activity of dorsal hippocampal metabotropic 
      glutamate receptors.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Alijanpour, Sakineh
AU  - Alijanpour S
AD  - Department of Biology, Faculty of Science, Gonbad Kavous University, Gonbad 
      Kavous, Iran. Electronic address: Alijanpour@gonbad.ac.ir.
FAU - Arabi-Shirazi, Ameneh
AU  - Arabi-Shirazi A
AD  - Department of Biology, Tehran North branch, Islamic Azad University, Tehran, 
      Iran.
FAU - Khakpai, Fatemeh
AU  - Khakpai F
AD  - Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences 
      Branch, Islamic Azad University, Tehran, Iran.
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran 
      University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism 
      Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Sharifi, Khadijeh-Alsadat
AU  - Sharifi KA
AD  - Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180818
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (2-amino-4-phosphono-propinate)
RN  - 0 (Propionates)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (cyclopropyl-4-phosphonophenylglycine)
RN  - 76I7G6D29C (Morphine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Glycine/analogs & derivatives/pharmacology
MH  - Hippocampus/drug effects/*metabolism/physiology
MH  - Male
MH  - Memory/*drug effects
MH  - Mice
MH  - Morphine/*pharmacology
MH  - Propionates/pharmacology
MH  - Receptors, Metabotropic Glutamate/*metabolism
OTO - NOTNLM
OT  - CPPG
OT  - L-AP4
OT  - Memory retention
OT  - Mice
OT  - Morphine
EDAT- 2018/08/21 06:00
MHDA- 2018/12/28 06:00
CRDT- 2018/08/21 06:00
PHST- 2018/04/22 00:00 [received]
PHST- 2018/07/21 00:00 [revised]
PHST- 2018/08/16 00:00 [accepted]
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2018/12/28 06:00 [medline]
PHST- 2018/08/21 06:00 [entrez]
AID - S0014-2999(18)30476-X [pii]
AID - 10.1016/j.ejphar.2018.08.023 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2018 Oct 5;836:44-49. doi: 10.1016/j.ejphar.2018.08.023. Epub 
      2018 Aug 18.