PMID- 30125821
OWN - NLM
STAT- MEDLINE
DCOM- 20190208
LR  - 20190215
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 241
DP  - 2018 Dec 1
TI  - Low brain-derived neurotrophic factor levels in post-mortem brains of older 
      adults with depression and dementia in a large clinicopathological sample.
PG  - 176-181
LID - S0165-0327(18)31114-5 [pii]
LID - 10.1016/j.jad.2018.08.025 [doi]
AB  - BACKGROUND: Disturbances in peripheral brain-derived neurotrophic factor (BDNF) 
      have been reported in major depressive disorder (MDD). However, there are no 
      studies measuring BDNF levels directly in post-mortem brains of older subjects 
      with MDD and dementia. We aimed to verify if brain BDNF levels were lower in 
      older adults with lifetime history of MDD with and without dementia. METHODS: 
      BDNF levels of post-mortem brains from 80 community-dwelling older individuals 
      with lifetime MDD with and without dementia were compared with levels from 80 
      controls without lifetime MDD. Participants with no reliable close informant, or 
      with prolonged agonal state were excluded. Lifetime MDD was defined as at least 
      one previous episode according to the Structured Clinical Interview for DSM 
      (SCID). RESULTS: BDNF levels were lower in the MDD group with dementia than in 
      participants with dementia and without MDD as confirmed by multivariate analysis 
      adjusted for clinical and cardiovascular risk factors (ss = -0.106, 
      95%CI = -0.204; -0.009, p = 0.034). No difference was found in the group with MDD 
      without dementia compared with their controls. LIMITATIONS: The retrospective 
      assessment of a lifetime history of depression may be subject to information bias 
      and this study only establishes a cross-sectional association between lifetime 
      history of MDD and lower levels of BDNF in patients with dementia. CONCLUSIONS: 
      In this community sample of older individuals, lower brain BDNF levels were found 
      in cases with both lifetime MDD and dementia. Low BDNF levels could be a 
      moderator to accelerated brain aging observed in MDD with dementia.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Nunes, Paula Villela
AU  - Nunes PV
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil. Electronic address: 
      paula@formato.com.br.
FAU - Nascimento, Camila Fernandes
AU  - Nascimento CF
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Kim, Helena Kyunghee
AU  - Kim HK
AD  - Department of Pharmacology and Toxicology, University of Toronto, Canada.
FAU - Andreazza, Ana Cristina
AU  - Andreazza AC
AD  - Department of Pharmacology and Toxicology, University of Toronto, Canada.
FAU - Brentani, Helena Paula
AU  - Brentani HP
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Suemoto, Claudia Kimie
AU  - Suemoto CK
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Leite, Renata Elaine Paraizo
AU  - Leite REP
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Ferretti-Rebustini, Renata Eloah de Lucena
AU  - Ferretti-Rebustini REL
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil; Escola de Enfermagem, 
      Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Pasqualucci, Carlos Augusto
AU  - Pasqualucci CA
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Nitrini, Ricardo
AU  - Nitrini R
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Grinberg, Lea Tenenholz
AU  - Grinberg LT
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil; Memory and Aging Center 
      University of California, San Francisco, USA.
FAU - Yong, Lionel Trevor
AU  - Yong LT
AD  - Department of Pharmacology and Toxicology, University of Toronto, Canada.
FAU - Jacob-Filho, Wilson
AU  - Jacob-Filho W
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
FAU - Lafer, Beny
AU  - Lafer B
AD  - Faculdade de Medicina FMUSP, Universidade de Sao Paulo, PROMAN, r. Dr. Ovidio 
      Pires de Campos, 785, Sao Paulo 01060-970, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180809
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Autopsy
MH  - *Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - Cross-Sectional Studies
MH  - Dementia/*metabolism/psychology
MH  - Depressive Disorder, Major/*metabolism/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - BDNF
OT  - Dementia
OT  - Depression
OT  - Older adults
OT  - Post-mortem
EDAT- 2018/08/21 06:00
MHDA- 2019/02/09 06:00
CRDT- 2018/08/21 06:00
PHST- 2018/05/21 00:00 [received]
PHST- 2018/07/02 00:00 [revised]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/08/21 06:00 [pubmed]
PHST- 2019/02/09 06:00 [medline]
PHST- 2018/08/21 06:00 [entrez]
AID - S0165-0327(18)31114-5 [pii]
AID - 10.1016/j.jad.2018.08.025 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Dec 1;241:176-181. doi: 10.1016/j.jad.2018.08.025. Epub 
      2018 Aug 9.