PMID- 30126158
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181207
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 23
IP  - 8
DP  - 2018 Aug 17
TI  - Beneficial Effect of Herbal Formulation KM1608 on Inflammatory Bowl Diseases: A 
      Preliminary Experimental Study.
LID - 10.3390/molecules23082068 [doi]
LID - 2068
AB  - Aucklandia lappa DC., Terminalia chebula Retz and Zingiber officinale Roscoe have 
      been traditionally used in east Asia to treat chronic diarrhea and abdominal 
      pain. This study aimed to evaluated the anti-inflammatory activity of KM1608, 
      which is composed of three natural herbs in a mouse model of dextran sodium 
      sulfate (DSS)-induced ulcerative colitis. The anti-inflammatory activity and 
      underlying mechanism were assessed in vitro using LPS-treated RAW264.7 cells. The 
      in vivo effect of KM1608 on DSS-induced colitis was examined after oral 
      administration in mice. KM1608 significantly inhibited the inflammatory mediators 
      such as nitric oxide, interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) 
      and tumor necrosis factor (TNF)-alpha in LPS-treated RAW264.7 cells. The inhibitory 
      effect of KM1608 was attributed to the reduction of Akt phosphorylation in the 
      LPS-treated cells. In the mouse model, oral administration of KM1608 
      significantly improved DSS-induced colitis symptoms, such as disease activity 
      index (DAI), colon length, and colon weight, as well as suppressed the expression 
      of IL-6, TNF-alpha, and myeloperoxidase (MPO) in the DSS-induced colitis tissues. 
      Taken together, KM1608 improved colitis through the regulation of inflammatory 
      responses, suggesting that KM1608 has potential therapeutic use in the treatment 
      of inflammatory diseases.
FAU - Shin, Myoung-Sook
AU  - Shin MS
AD  - College of Korean Medicine, Gachon University, Seongnam-si, Gyeonggi-do 13120, 
      Korea. ms.shin@gachon.ac.kr.
FAU - Kim, Sang-Back
AU  - Kim SB
AD  - New Drug Research Team, Kolmar, Korea Co. Ltd, Sandan-gil, Jeonui-myeon, 
      Sejong-si 30003, Korea. m302@kolmar.co.kr.
FAU - Lee, Jaemin
AU  - Lee J
AD  - College of Korean Medicine, Gachon University, Seongnam-si, Gyeonggi-do 13120, 
      Korea. jaemin.lee426@gmail.com.
FAU - Choi, Han-Seok
AU  - Choi HS
AD  - New Drug Research Team, Kolmar, Korea Co. Ltd, Sandan-gil, Jeonui-myeon, 
      Sejong-si 30003, Korea. fcosmos@kolmar.co.kr.
FAU - Park, Jimin
AU  - Park J
AD  - New Drug Research Team, Kolmar, Korea Co. Ltd, Sandan-gil, Jeonui-myeon, 
      Sejong-si 30003, Korea. jimpark@kolmar.co.kr.
FAU - Park, Jun Yeon
AU  - Park JY
AD  - Department of Food Science and Biotechnology, Kyonggi University, Suwon-si, 
      Gyeonggi-do 16227, Korea. rhemf@hanmail.net.
FAU - Lee, Sullim
AU  - Lee S
AD  - Department of Life Science, College of Bio-Nano Technology, Gachon University, 
      Seongnam-si, Gyeonggi-do 13120, Korea. sullimlee@gachon.ac.kr.
FAU - Hwang, Gwi Seo
AU  - Hwang GS
AD  - College of Korean Medicine, Gachon University, Seongnam-si, Gyeonggi-do 13120, 
      Korea. seoul@gachon.ac.kr.
FAU - Koo, Bon Am
AU  - Koo BA
AD  - New Drug Research Team, Kolmar, Korea Co. Ltd, Sandan-gil, Jeonui-myeon, 
      Sejong-si 30003, Korea. bakoo9@kolmar.co.kr.
FAU - Kang, Ki Sung
AU  - Kang KS
AD  - College of Korean Medicine, Gachon University, Seongnam-si, Gyeonggi-do 13120, 
      Korea. kkang@gachon.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180817
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Phytochemicals)
RN  - 0 (Plant Extracts)
RN  - 9042-14-2 (Dextran Sulfate)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/analysis/*chemistry/*pharmacology
MH  - Chromatography, High Pressure Liquid
MH  - Colitis/drug therapy/etiology/pathology
MH  - Cytokines/metabolism
MH  - Dextran Sulfate/adverse effects
MH  - Disease Models, Animal
MH  - Inflammation Mediators/metabolism
MH  - Inflammatory Bowel Diseases/drug therapy/pathology
MH  - Mice
MH  - Oxidation-Reduction/drug effects
MH  - Phosphorylation/drug effects
MH  - Phytochemicals/analysis
MH  - Plant Extracts/analysis/*chemistry/*pharmacology
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - RAW 264.7 Cells
PMC - PMC6222370
OTO - NOTNLM
OT  - Aucklandia lappa DC.
OT  - Terminalia chebula Retz.
OT  - Zingiber officinale Roscoe
OT  - anti-inflammatory
OT  - ulcerative colitis
COIS- The authors declare no conflict of interest.
EDAT- 2018/08/22 06:00
MHDA- 2018/11/06 06:00
PMCR- 2018/08/17
CRDT- 2018/08/22 06:00
PHST- 2018/07/17 00:00 [received]
PHST- 2018/08/03 00:00 [revised]
PHST- 2018/08/14 00:00 [accepted]
PHST- 2018/08/22 06:00 [entrez]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/08/17 00:00 [pmc-release]
AID - molecules23082068 [pii]
AID - molecules-23-02068 [pii]
AID - 10.3390/molecules23082068 [doi]
PST - epublish
SO  - Molecules. 2018 Aug 17;23(8):2068. doi: 10.3390/molecules23082068.