PMID- 30127051 OWN - NLM STAT- MEDLINE DCOM- 20191022 LR - 20220129 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 8 IP - 8 DP - 2018 Aug 20 TI - Protocol of economic evaluation and equity impact analysis of mHealth and community groups for prevention and control of diabetes in rural Bangladesh in a three-arm cluster randomised controlled trial. PG - e022035 LID - 10.1136/bmjopen-2018-022035 [doi] LID - e022035 AB - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of death and disability worldwide, generating substantial economic burden for people with diabetes and their families, and to health systems and national economies. Bangladesh has one of the largest numbers of adults with diabetes in the South Asian region. This paper describes the planned economic evaluation of a three-arm cluster randomised control trial of mHealth and community mobilisation interventions to prevent and control T2DM and non-communicable diseases' risk factors in rural Bangladesh (D-Magic trial). METHODS AND ANALYSIS: The economic evaluation will be conducted as a within-trial analysis to evaluate the incremental costs and health outcomes of mHealth and community mobilisation interventions compared with the status quo. The analyses will be conducted from a societal perspective, assessing the economic impact for all parties affected by the interventions, including implementing agencies (programme costs), healthcare providers, and participants and their households. Incremental cost-effectiveness ratios (ICERs) will be calculated in terms of cost per case of intermediate hyperglycaemia and T2DM prevented and cost per case of diabetes prevented among individuals with intermediate hyperglycaemia at baseline and cost per mm Hg reduction in systolic blood pressure. In addition to ICERs, the economic evaluation will be presented as a cost-consequence analysis where the incremental costs and all statistically significant outcomes will be listed separately. Robustness of the results will be assessed through sensitivity analyses. In addition, an analysis of equity impact of the interventions will be conducted. ETHICS AND DISSEMINATION: The approval to conduct the study was obtained by the University College London Research Ethics Committee (4766/002) and by the Ethical Review Committee of the Diabetic Association of Bangladesh (BADAS-ERC/EC/t5100246). The findings of this study will be disseminated through different means within academia and the wider policy sphere. TRIAL REGISTRATION NUMBER: ISRCTN41083256; Pre-results. CI - (c) Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. FAU - Haghparast-Bidgoli, Hassan AU - Haghparast-Bidgoli H AUID- ORCID: 0000-0001-6365-2944 AD - Institute for Global Health, University College London, London, UK. FAU - Shaha, Sanjit Kumar AU - Shaha SK AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Kuddus, Abdul AU - Kuddus A AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Chowdhury, Md Alimul Reza AU - Chowdhury MAR AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Jennings, Hannah AU - Jennings H AD - Institute for Global Health, University College London, London, UK. FAU - Ahmed, Naveed AU - Ahmed N AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Morrison, Joanna AU - Morrison J AD - Institute for Global Health, University College London, London, UK. FAU - Akter, Kohenour AU - Akter K AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Nahar, Badrun AU - Nahar B AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Nahar, Tasmin AU - Nahar T AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - King, Carina AU - King C AUID- ORCID: 0000-0002-6885-6716 AD - Institute for Global Health, University College London, London, UK. FAU - Skordis-Worrall, Jolene AU - Skordis-Worrall J AD - Institute for Global Health, University College London, London, UK. FAU - Batura, Neha AU - Batura N AUID- ORCID: 0000-0002-8175-8125 AD - Institute for Global Health, University College London, London, UK. FAU - Khan, Jahangir A AU - Khan JA AD - Liverpool School of Tropical Medicine, Liverpool, UK. FAU - Mansaray, Anthony AU - Mansaray A AD - ICAP Sierra Leone, Freetown, Sierra Leone. FAU - Hunter, Rachael AU - Hunter R AUID- ORCID: 0000-0002-7447-8934 AD - Institute of Epidemiology & Health, University College London, London, UK. FAU - Khan, A K Azad AU - Khan AKA AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Costello, Anthony AU - Costello A AD - Institute for Global Health, University College London, London, UK. AD - World Health Organization, Geneva, Switzerland. FAU - Azad, Kishwar AU - Azad K AD - Diabetic Association of Bangladesh, Dhaka, Dhaka District, Bangladesh. FAU - Fottrell, Edward AU - Fottrell E AD - Institute for Global Health, University College London, London, UK. LA - eng SI - ISRCTN/ISRCTN41083256 GR - 001/WHO_/World Health Organization/International GR - MR/M016501/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20180820 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adult MH - Bangladesh MH - Community Health Services/*methods MH - Cost-Benefit Analysis MH - Diabetes Mellitus, Type 2/*prevention & control MH - Female MH - Health Care Costs MH - Humans MH - Male MH - Program Evaluation MH - Research Design MH - Risk Factors MH - Rural Population MH - Telemedicine/economics/*methods PMC - PMC6104763 OTO - NOTNLM OT - health economics OT - health policy COIS- Competing interests: None declared. EDAT- 2018/08/22 06:00 MHDA- 2019/10/23 06:00 PMCR- 2018/08/20 CRDT- 2018/08/22 06:00 PHST- 2018/08/22 06:00 [entrez] PHST- 2018/08/22 06:00 [pubmed] PHST- 2019/10/23 06:00 [medline] PHST- 2018/08/20 00:00 [pmc-release] AID - bmjopen-2018-022035 [pii] AID - 10.1136/bmjopen-2018-022035 [doi] PST - epublish SO - BMJ Open. 2018 Aug 20;8(8):e022035. doi: 10.1136/bmjopen-2018-022035.