PMID- 30127510 OWN - NLM STAT- MEDLINE DCOM- 20191024 LR - 20191024 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 8 IP - 1 DP - 2018 Aug 20 TI - Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial. PG - 12477 LID - 10.1038/s41598-018-30127-z [doi] LID - 12477 AB - Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and working memory and its association with brain-derived neurotrophic factor (BDNF) levels. Forty females with fibromyalgia were randomized to receive eight sessions of active or sham tDCS. Anodal stimulation (2 mA) was applied over the DLPFC and online combined with a working memory training (WMT) for 20 minutes. Pre and post-treatment neurocognitive tests were administered. Data analysis on deltas considering years of education and BDNF as covariates, indicated active-tDCS + WMT significantly increased immediate memory indexed by Rey Auditory Verbal Learning Test score when compared to sham. This effect was dependent on basal BDNF levels. In addition, the model showed active stimulation increased orthographic and semantic verbal fluency scores (Controlled Oral Word Association Test) and short-term memory (Forward Digit Span). The combination of both techniques seemed to produce effects on specific cognitive functions related to short-term and long-term episodic memory and executive functions, which has clinical relevance for top-down treatment approaches in FM. FAU - Santos, Vinicius Souza Dos Souza Dos AU - Santos VSDSD AD - Post-graduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. FAU - Zortea, Maxciel AU - Zortea M AD - Post-graduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. FAU - Alves, Rael Lopes AU - Alves RL AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. AD - Graduation Program in Psychology, UFRGS, Porto Alegre, Brazil. FAU - Naziazeno, Catia Cilene Dos Santos AU - Naziazeno CCDS AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. FAU - Saldanha, Julia Schirmer AU - Saldanha JS AD - Post-graduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. FAU - Carvalho, Sandra da Conceicao Ribeiro de AU - Carvalho SDCR AD - Laboratory of Neurophysiology, University of Minho, Braga, Portugal. AD - Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, United States. FAU - Leite, Antonio Jorge da Costa AU - Leite AJDC AUID- ORCID: 0000-0002-0323-9012 AD - Laboratory of Neurophysiology, University of Minho, Braga, Portugal. AD - Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, United States. FAU - Torres, Iraci Lucena da Silva AU - Torres ILDS AD - Post-Graduation Program in Biological Sciences, Physiology, UFRGS, Porto Alegre, Brazil. AD - Pharmacology of Pain and Neuromodulation: Pre-clinical Investigations, UFRGS, Porto Alegre, Brazil. FAU - Souza, Andressa de AU - Souza A AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. AD - Post-Graduation Program in Health and Human Development, La Salle University, Philadelphia, United States. FAU - Calvetti, Prisla Ucker AU - Calvetti PU AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. FAU - Fregni, Felipe AU - Fregni F AD - Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, United States. FAU - Caumo, Wolnei AU - Caumo W AD - Post-graduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. wcaumo@hcpa.edu.br. AD - Laboratory of Pain & Neuromodulation, Clinical Hospital of Porto Alegre (HCPA), Porto Alegre, Brazil. wcaumo@hcpa.edu.br. AD - Pain and Palliative Care Service at Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Brazil. wcaumo@hcpa.edu.br. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20180820 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Cognition/*physiology MH - Cognitive Dysfunction MH - Executive Function/physiology MH - Female MH - Fibromyalgia/*physiopathology MH - Humans MH - Learning MH - Male MH - Memory, Short-Term MH - Middle Aged MH - Neuropsychological Tests MH - Prefrontal Cortex/physiopathology MH - Transcranial Direct Current Stimulation/methods PMC - PMC6102237 COIS- The authors declare no competing interests. EDAT- 2018/08/22 06:00 MHDA- 2019/10/28 06:00 PMCR- 2018/08/20 CRDT- 2018/08/22 06:00 PHST- 2018/01/31 00:00 [received] PHST- 2018/07/17 00:00 [accepted] PHST- 2018/08/22 06:00 [entrez] PHST- 2018/08/22 06:00 [pubmed] PHST- 2019/10/28 06:00 [medline] PHST- 2018/08/20 00:00 [pmc-release] AID - 10.1038/s41598-018-30127-z [pii] AID - 30127 [pii] AID - 10.1038/s41598-018-30127-z [doi] PST - epublish SO - Sci Rep. 2018 Aug 20;8(1):12477. doi: 10.1038/s41598-018-30127-z.