PMID- 30127717
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 11
DP  - 2018
TI  - Visualizing BDNF Transcript Usage During Sound-Induced Memory Linked Plasticity.
PG  - 260
LID - 10.3389/fnmol.2018.00260 [doi]
LID - 260
AB  - Activity-dependent BDNF (brain-derived neurotrophic factor) expression is 
      hypothesized to be a cue for the context-specificity of memory formation. So far, 
      activity-dependent BDNF cannot be explicitly monitored independently of basal 
      BDNF levels. We used the BLEV ( B DNF- live-exon- visualization) reporter mouse 
      to specifically detect activity-dependent usage of Bdnf exon-IV and -VI promoters 
      through bi-cistronic co-expression of CFP and YFP, respectively. Enriching 
      acoustic stimuli led to improved peripheral and central auditory brainstem 
      responses, increased Schaffer collateral LTP, and enhanced performance in the 
      Morris water maze. Within the brainstem, neuronal activity was increased and 
      accompanied by a trend for higher expression levels of Bdnf exon-IV-CFP and 
      exon-VI-YFP transcripts. In the hippocampus BDNF transcripts were clearly 
      increased parallel to changes in parvalbumin expression and were localized to 
      specific neurons and capillaries. Severe acoustic trauma, in contrast, elevated 
      neither Bdnf transcript levels, nor auditory responses, parvalbumin or LTP. 
      Together, this suggests that critical sensory input is essential for recruitment 
      of activity-dependent auditory-specific BDNF expression that may shape network 
      adaptation.
FAU - Matt, Lucas
AU  - Matt L
AD  - Department of Pharmacology, Institute of Pharmacy, Toxicology, and Clinical 
      Pharmacy, University of Tubingen, Tubingen, Germany.
FAU - Eckert, Philipp
AU  - Eckert P
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Panford-Walsh, Rama
AU  - Panford-Walsh R
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Geisler, Hyun-Soon
AU  - Geisler HS
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Bausch, Anne E
AU  - Bausch AE
AD  - Department of Pharmacology, Institute of Pharmacy, Toxicology, and Clinical 
      Pharmacy, University of Tubingen, Tubingen, Germany.
FAU - Manthey, Marie
AU  - Manthey M
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Muller, Nicolas I C
AU  - Muller NIC
AD  - Animal Physiology Group, Department of Biology, University of Kaiserslautern, 
      Kaiserslautern, Germany.
FAU - Harasztosi, Csaba
AU  - Harasztosi C
AD  - Section of Physiological Acoustics and Communication, Department of 
      Otolaryngology, Tubingen Hearing Research Center, University of Tubingen, 
      Tubingen, Germany.
FAU - Rohbock, Karin
AU  - Rohbock K
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Ruth, Peter
AU  - Ruth P
AD  - Department of Pharmacology, Institute of Pharmacy, Toxicology, and Clinical 
      Pharmacy, University of Tubingen, Tubingen, Germany.
FAU - Friauf, Eckhard
AU  - Friauf E
AD  - Animal Physiology Group, Department of Biology, University of Kaiserslautern, 
      Kaiserslautern, Germany.
FAU - Ott, Thomas
AU  - Ott T
AD  - Transgenic Facility Tubingen, University of Tubingen, Tubingen, Germany.
FAU - Zimmermann, Ulrike
AU  - Zimmermann U
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Ruttiger, Lukas
AU  - Ruttiger L
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Schimmang, Thomas
AU  - Schimmang T
AD  - Instituto de Biologiay Genetica Molecular, Universidad de Valladolid, Consejo 
      Superior de Investigaciones Cientificas (CSIC), Valladolid, Spain.
FAU - Knipper, Marlies
AU  - Knipper M
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
FAU - Singer, Wibke
AU  - Singer W
AD  - Department of Otolaryngology, Tubingen Hearing Research Centre, Molecular 
      Physiology of Hearing, University of Tubingen, Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180731
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC6089339
OTO - NOTNLM
OT  - Bdnf exon-IV
OT  - Bdnf exon-VI
OT  - LTP
OT  - feed-forward inhibition
OT  - memory acquisition
OT  - parvalbumin
OT  - sound-accentuation
OT  - vasculature
EDAT- 2018/08/22 06:00
MHDA- 2018/08/22 06:01
PMCR- 2018/01/01
CRDT- 2018/08/22 06:00
PHST- 2018/04/18 00:00 [received]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/08/22 06:00 [entrez]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/08/22 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2018.00260 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2018 Jul 31;11:260. doi: 10.3389/fnmol.2018.00260. 
      eCollection 2018.