PMID- 30127804
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1687-9848 (Print)
IS  - 1687-9856 (Electronic)
IS  - 1687-9848 (Linking)
VI  - 2018
DP  - 2018
TI  - Multiple endocrine neoplasia type 1 presenting with concurrent insulinoma and 
      prolactinoma in early-adolescence.
PG  - 7
LID - 10.1186/s13633-018-0061-6 [doi]
LID - 7
AB  - BACKGROUND: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal 
      dominant disease that generally presents with primary hyperparathyroidism. 
      However, initial presentation may vary and continued reevaluation of etiology of 
      symptoms is required for appropriate diagnosis. CASE PRESENTATION: Twelve year 
      old female presented with altered mental status that self-resolved and 
      hypoglycemia. Laboratory evaluation revealed pituitary dysfunction with central 
      hypothyroidism and adrenal insufficiency in the setting of hyperprolactinemia. 
      Macroadenoma was confirmed on imaging. Despite medical treatment of pituitary 
      hormone disorders, she continued to have significant hypoglycemia and further 
      workup revealed hyperinsulinism. Insulinoma was identified and confirmed by 
      endoscopic ultrasound. Hypoglycemia resolved after laproscopic enucleation of the 
      insulinoma. CONCLUSION: Children presenting with one endocrine tumor should be 
      investigated for other potential endocrine tumors. Multiple imaging modalities 
      may be required to confidently identify neuroendocrine tumors for appropriate 
      surgical intervention.
FAU - Akhtar, Yasmin
AU  - Akhtar Y
AD  - Department of Pediatrics, Johns Hopkins University School of Medicine, 200 N 
      Wolfe St, Rm 3120, Baltimore, MD 21287 USA. ISNI: 0000 0001 2171 9311. GRID: 
      grid.21107.35
FAU - Verardo, Angela
AU  - Verardo A
AD  - Department of Pediatrics, Johns Hopkins University School of Medicine, 200 N 
      Wolfe St, Rm 3120, Baltimore, MD 21287 USA. ISNI: 0000 0001 2171 9311. GRID: 
      grid.21107.35
FAU - Crane, Janet L
AU  - Crane JL
AUID- ORCID: 0000-0001-7713-0936
AD  - Department of Pediatrics, Johns Hopkins University School of Medicine, 200 N 
      Wolfe St, Rm 3120, Baltimore, MD 21287 USA. ISNI: 0000 0001 2171 9311. GRID: 
      grid.21107.35
LA  - eng
PT  - Case Reports
DEP - 20180806
PL  - England
TA  - Int J Pediatr Endocrinol
JT  - International journal of pediatric endocrinology
JID - 101516111
PMC - PMC6091168
OTO - NOTNLM
OT  - Insulinoma
OT  - MEN1
OT  - Prolactinoma
COIS- Per Johns Hopkins University Institutional Review Board Policy (IRB), case 
      reports do not require IRB approval. Per the United States Health Insurance 
      Portability and Accountability Act of 1996, assent and consent for publication 
      was obtained from the patient and her parent, respectively. All authors declare 
      that they have no competing interests. Springer Nature remains neutral with 
      regard to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/08/22 06:00
MHDA- 2018/08/22 06:01
PMCR- 2018/08/06
CRDT- 2018/08/22 06:00
PHST- 2018/04/04 00:00 [received]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/08/22 06:00 [entrez]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/08/22 06:01 [medline]
PHST- 2018/08/06 00:00 [pmc-release]
AID - 61 [pii]
AID - 10.1186/s13633-018-0061-6 [doi]
PST - ppublish
SO  - Int J Pediatr Endocrinol. 2018;2018:7. doi: 10.1186/s13633-018-0061-6. Epub 2018 
      Aug 6.