PMID- 30127914
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 16
IP  - 3
DP  - 2018 Sep
TI  - Mitochondrial ROS activate interleukin-1beta expression in allergic rhinitis.
PG  - 3193-3200
LID - 10.3892/ol.2018.8984 [doi]
AB  - Allergic rhinitis (AR) is the most common cause of inflammation of the nasal 
      mucosa. It is also the most common form of non-infectious rhinitis associated 
      with an immunoglobulin E (IgE)-mediated immune response against allergens. 
      Previous studies have indicated that interleukin-1beta (IL-1beta) has a pathological 
      role in the development of allergic asthma. The present study was designed to 
      assess whether IL-1beta participates in the pathogenesis of AR. A total of 45 
      patients with AR were enrolled in the present study and were identified to have 
      increased IL-1beta expression expressed by peripheral blood mononuclear cells 
      (PBMCs), and the mitochondrial reactive oxygen species (ROS) and NLRP3 are 
      required for IL-1beta synthesis in monocytes/macrophages and PBMCs from patients 
      with AR. The levels of IL-1beta and interleukin-17 (IL-17) were increased in 
      patients with AR and were positively correlated with each other. The results of 
      the present study suggested that patients with AR have raised mitochondrial ROS 
      levels, which may upregulate the expression of IL-1beta, affecting IL-17-production 
      and serving a role in the pathogenesis of AR.
FAU - Shi, Qiping
AU  - Shi Q
AD  - Endocrine Department, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong 510632, P.R. China.
AD  - Biomedical Translational Research Institute, Jinan University, Guangzhou, 
      Guangdong 510632, P.R. China.
FAU - Lei, Zhiwei
AU  - Lei Z
AD  - Biomedical Translational Research Institute, Jinan University, Guangzhou, 
      Guangdong 510632, P.R. China.
FAU - Cheng, Gui
AU  - Cheng G
AD  - Endocrine Department, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong 510632, P.R. China.
FAU - Li, Dehai
AU  - Li D
AD  - Biomedical Translational Research Institute, Jinan University, Guangzhou, 
      Guangdong 510632, P.R. China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Biomedical Translational Research Institute, Jinan University, Guangzhou, 
      Guangdong 510632, P.R. China.
FAU - Luo, Simin
AU  - Luo S
AD  - Endocrine Department, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong 510632, P.R. China.
FAU - Yang, Hengwen
AU  - Yang H
AD  - Biomedical Translational Research Institute, Jinan University, Guangzhou, 
      Guangdong 510632, P.R. China.
FAU - Jia, Haiying
AU  - Jia H
AD  - Endocrine Department, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong 510632, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180618
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6096070
OTO - NOTNLM
OT  - NLRP3
OT  - allergic rhinitis
OT  - inflammasome
OT  - interleukin-17
OT  - interleukin-1beta
OT  - mitochondrial reactive oxygen species
EDAT- 2018/08/22 06:00
MHDA- 2018/08/22 06:01
PMCR- 2018/06/18
CRDT- 2018/08/22 06:00
PHST- 2017/03/01 00:00 [received]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/08/22 06:00 [entrez]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/08/22 06:01 [medline]
PHST- 2018/06/18 00:00 [pmc-release]
AID - OL-0-0-8984 [pii]
AID - 10.3892/ol.2018.8984 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Sep;16(3):3193-3200. doi: 10.3892/ol.2018.8984. Epub 2018 Jun 
      18.