PMID- 30128029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 16
IP  - 3
DP  - 2018 Sep
TI  - Proteins involved in cutaneous basal cell carcinoma development.
PG  - 4064-4072
LID - 10.3892/ol.2018.9126 [doi]
AB  - Basal cell carcinoma (BCC) is the most common skin malignancy type in the 
      Caucasian population, with a continuously increasing incidence rate. The etiology 
      of BCC remains unknown, but it appears to have a multifactorial origin resulting 
      from intrinsic and extrinsic factors, including short-wavelength ultraviolet B 
      radiation. The role of specific proteins in BCC that are known to be responsible 
      for the regulation of cell division and are involved in skin aging, including 
      transforming growth factor (TGF)-beta, Smad2, matrix metalloproteinases (MMPs)-1, 
      -3, -8 and -9, cathepsin-K and progerin, remains unknown. The aim of the present 
      study was to assess the mRNA and protein expression profile of samples with 
      diagnosed nodular BCC (nBCC) compared with that of healthy skin samples collected 
      from matched areas. The study group included 22 patients (10 men and 12 women; 
      mean age, 59 years; range, 44-82 years) with pathologically confirmed nBCC, and 
      22 healthy volunteers (10 men and 12 women; mean age, 59 years; range, 43-78 
      years) as a control group. The expression of the studied proteins was assessed in 
      all samples by western blotting and reverse transcription-quantitative polymerase 
      chain reaction analysis. Statistically significant increases in the expression of 
      TGF-beta, Smad2, cathepsin-K, progerin and MMP-1, -3, -8 and -9 were detected in 
      skin biopsies with diagnosed nBCC compared with the control group, confirming the 
      important role of these proteins in skin carcinogenesis.
FAU - Ciazynska, Magdalena
AU  - Ciazynska M
AD  - Department of Proliferative Diseases, Regional Oncology Centre, Lodz 93-513, 
      Poland.
FAU - Bednarski, Igor A
AU  - Bednarski IA
AD  - Department of Dermatology, Paediatric Dermatology and Dermatological Oncology, 
      Medical University of Lodz, Lodz 91-347, Poland.
FAU - Wodz, Karolina
AU  - Wodz K
AD  - Department of Experimental Immunology, Medical University of Lodz, Lodz 90-237, 
      Poland.
FAU - Kolano, Pawel
AU  - Kolano P
AD  - Department of General and Oncological Surgery, Tomaszow Health Centre, Tomaszow 
      Mazowiecki 97-200, Poland.
FAU - Narbutt, Joanna
AU  - Narbutt J
AD  - Department of Dermatology, Paediatric Dermatology and Dermatological Oncology, 
      Medical University of Lodz, Lodz 91-347, Poland.
FAU - Sobjanek, Michal
AU  - Sobjanek M
AD  - Department of Dermatology, Venereology and Allergy, Medical University of Gdansk, 
      Gdansk 80-210, Poland.
FAU - Wozniacka, Anna
AU  - Wozniacka A
AD  - Department of Dermatology and Venereology, Medical University of Lodz, Lodz 
      90-647, Poland.
FAU - Lesiak, Aleksandra
AU  - Lesiak A
AD  - Department of Dermatology, Paediatric Dermatology and Dermatological Oncology, 
      Medical University of Lodz, Lodz 91-347, Poland.
LA  - eng
PT  - Journal Article
DEP - 20180711
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6096141
OTO - NOTNLM
OT  - biomedical recurrence
OT  - gene expression
OT  - model
OT  - prognosis
OT  - prostate cancer
EDAT- 2018/08/22 06:00
MHDA- 2018/08/22 06:01
PMCR- 2018/07/11
CRDT- 2018/08/22 06:00
PHST- 2017/11/12 00:00 [received]
PHST- 2018/04/12 00:00 [accepted]
PHST- 2018/08/22 06:00 [entrez]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/08/22 06:01 [medline]
PHST- 2018/07/11 00:00 [pmc-release]
AID - OL-0-0-9126 [pii]
AID - 10.3892/ol.2018.9126 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Sep;16(3):4064-4072. doi: 10.3892/ol.2018.9126. Epub 2018 Jul 
      11.