PMID- 30128812
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20190325
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 70
IP  - 10
DP  - 2018 Nov
TI  - Human leukocyte antigen (HLA)-C and its association with HIV-1 transmission in 
      discordant couple and mother-to-child cohorts.
PG  - 633-638
LID - 10.1007/s00251-018-1075-1 [doi]
AB  - Human leukocyte antigen (HLA) molecules play a key role in regulating the immune 
      response towards infectious agents like human immunodeficiency virus type-1 
      (HIV-1). They have been shown to influence transmission as well as the 
      progression of HIV-1 towards acquired immune deficiency syndrome (AIDS). Roles of 
      HLA-A and HLA-B have been documented extensively; however, HLA-C has been poorly 
      studied. In the present study, we have evaluated the role of HLA-C in discordant 
      couple and mother-to-child cohorts. HLA-C*07 was higher both in HIV-1-infected 
      spouses and infants as compared to exposed uninfected spouses and infants. 
      However, this was not significant. HLA-C*15 was significantly higher in 
      HIV-1-exposed uninfected babies as compared to infected babies. Lack of treatment 
      in mothers and breastfeeding were significantly associated with HIV-1 
      transmission. HLA-C*07 may be a susceptible allele in HIV-1 transmission, whereas 
      HLA-C*15 may be a protective allele in mother-to-child cohorts, independent of 
      feeding options and treatment. These findings could be important in targeting 
      immune responses via population-specific vaccine strategies against HIV-1.
FAU - Bardeskar, N S
AU  - Bardeskar NS
AD  - Department of Infectious Diseases Biology, ICMR-National Institute for Research 
      in Reproductive Health, JM Street, Parel, Mumbai, 400012, India.
FAU - Chavan, V
AU  - Chavan V
AD  - Department of Infectious Diseases Biology, ICMR-National Institute for Research 
      in Reproductive Health, JM Street, Parel, Mumbai, 400012, India.
FAU - Ahir-Bist, S
AU  - Ahir-Bist S
AD  - Department of Infectious Diseases Biology, ICMR-National Institute for Research 
      in Reproductive Health, JM Street, Parel, Mumbai, 400012, India.
FAU - Nanavati, R
AU  - Nanavati R
AD  - Department of Neonatology, Seth GS Medical College and KEM Hospital, Parel, 
      Mumbai, 400012, India.
FAU - Samant-Mavani, P
AU  - Samant-Mavani P
AD  - Department of Obstetrics and Gynaecology, Seth GS Medical College and KEM 
      Hospital, Parel, Mumbai, 400012, India.
FAU - Mehta, P
AU  - Mehta P
AD  - Department of Microbiology, Seth GS Medical College and KEM Hospital, Parel, 
      Mumbai, 400012, India.
FAU - Mania-Pramanik, Jayanti
AU  - Mania-Pramanik J
AD  - Department of Infectious Diseases Biology, ICMR-National Institute for Research 
      in Reproductive Health, JM Street, Parel, Mumbai, 400012, India. 
      jayantimania@rediffmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180820
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - HIV Infections/*genetics/immunology/*transmission/virology
MH  - HIV-1/*genetics/pathogenicity
MH  - HLA-C Antigens/*genetics/immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Mother-Child Relations
OTO - NOTNLM
OT  - Discordant couple cohort
OT  - HIV-1 transmission
OT  - HLA-C
OT  - Human leukocyte antigen
OT  - Mother-to-child cohort
EDAT- 2018/08/22 06:00
MHDA- 2019/03/26 06:00
CRDT- 2018/08/22 06:00
PHST- 2018/05/29 00:00 [received]
PHST- 2018/08/08 00:00 [accepted]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/08/22 06:00 [entrez]
AID - 10.1007/s00251-018-1075-1 [pii]
AID - 10.1007/s00251-018-1075-1 [doi]
PST - ppublish
SO  - Immunogenetics. 2018 Nov;70(10):633-638. doi: 10.1007/s00251-018-1075-1. Epub 
      2018 Aug 20.