PMID- 30130756
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20200225
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 177
IP  - 3
DP  - 2018
TI  - Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study 
      in School Children on Flores Island, Indonesia.
PG  - 192-198
LID - 10.1159/000490952 [doi]
AB  - BACKGROUND: In many rural areas of tropical countries such as Indonesia, the 
      prevalence of soil-transmitted helminths (STH) infections remains high. At the 
      same time, the burden of allergic disorders in such rural areas is reported to be 
      low and inversely associated with helminth infections. To reduce the morbidity 
      and transmission of helminth infections, the world health organization recommends 
      preventive treatment of school children by providing mass drug administration 
      (MDA) with albendazole. Here, we had an opportunity to evaluate the prevalence of 
      skin reactivity to allergens before and after albendazole treatment to get an 
      indication of the possible impact of MDA on allergic sensitization. METHODS: A 
      study was conducted among 150 school children living in an area endemic for STH 
      infections. Before and 1 year after anthelminthic treatment with albendazole, 
      stool samples were examined for the presence of STH eggs, skin prick tests (SPT) 
      for cockroach and house dust mites were performed, blood eosinophilia was 
      assessed, and total immunoglobulin E (IgE) and C-reactive protein (CRP) were 
      measured in plasma. RESULTS: Anthelminthic treatment significantly reduced the 
      prevalence of STH from 19.6 before treatment to 6% after treatment (p < 0.001). 
      Levels of total IgE (estimate: 0.30; 95% CI 0.22-0.42, p < 0.0001), CRP 
      (estimate: 0.60; 95% CI 0.42-0.86, p = 0.006), and eosinophil counts (estimate: 
      0.70; 95% CI 0.61-0.80, p < 0.001) decreased significantly. The prevalence of SPT 
      positivity increased from 18.7 to 32.7%. Multivariate analysis adjusted for 
      confounding factors showed an increased risk of being SPT positive to any 
      allergen (OR 3.04; 95% CI 1.338-6.919, p = 0.008). CONCLUSIONS: This study 
      indicates that 1 year of MDA with albendazole was associated with a reduced 
      prevalence of STH infections. This study shows that the prevalence of allergic 
      sensitization increases after 1 year of albendazole treatment. Placebo-controlled 
      and larger studies are needed to further substantiate a role of deworming 
      treatment in an increased risk of allergic sensitization.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Staal, Steven L
AU  - Staal SL
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Hogendoorn, Sarika K L
AU  - Hogendoorn SKL
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Voets, Sophie A
AU  - Voets SA
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Tepper, Rebecca C
AU  - Tepper RC
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Veenstra, Mirte
AU  - Veenstra M
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - de Vos, Ivo I
AU  - de Vos II
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - van Son, Koen C
AU  - van Son KC
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Gool, Jari K
AU  - Gool JK
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Paramitha, Antonia C
AU  - Paramitha AC
AD  - Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      Indonesia.
FAU - Aristyo, Kevin
AU  - Aristyo K
AD  - Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      Indonesia.
FAU - Wildan, Ardy
AU  - Wildan A
AD  - Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      Indonesia.
FAU - Pratiwi, Chici
AU  - Pratiwi C
AD  - Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      Indonesia.
FAU - van Ree, Ronald
AU  - van Ree R
AD  - Departments of Experimental Immunology and Otorhinolaryngology, Academic Medical 
      Center, University of Amsterdam, Amsterdam, the Netherlands.
FAU - Yazdanbakhsh, Maria
AU  - Yazdanbakhsh M
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Supali, Taniawati
AU  - Supali T
AD  - Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      Indonesia.
FAU - Djuardi, Yenny
AU  - Djuardi Y
AD  - Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      Indonesia.
FAU - Labuda, Lucja A
AU  - Labuda LA
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Tahapary, Dicky L
AU  - Tahapary DL
AD  - Division of Endocrinology, Department of Internal Medicine, Dr. Cipto 
      Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia.
FAU - Sartono, Erliyani
AU  - Sartono E
AD  - Department of Parasitology, Leiden University Medical Center, Leiden, the 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20180821
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Anthelmintics)
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Antigens, Helminth)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/administration & dosage/therapeutic use
MH  - Allergens/immunology
MH  - Ancylostomatoidea/*immunology
MH  - Animals
MH  - Anthelmintics/administration & dosage/therapeutic use
MH  - Antibodies, Helminth/*blood/immunology
MH  - Antigens, Helminth/immunology
MH  - Ascaris lumbricoides/*immunology
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Cockroaches/immunology
MH  - Female
MH  - Helminthiasis/drug therapy/*epidemiology/parasitology
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*epidemiology/immunology
MH  - Immunoglobulin E/*blood/immunology
MH  - Indonesia/epidemiology
MH  - Male
MH  - Mass Drug Administration
MH  - Pyroglyphidae/immunology
MH  - Trichuris/*immunology
PMC - PMC6492509
OTO - NOTNLM
OT  - Allergens
OT  - Mass drug administration
OT  - Skin prick test
OT  - Soil-transmitted helminths
EDAT- 2018/08/22 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/08/21
CRDT- 2018/08/22 06:00
PHST- 2018/03/30 00:00 [received]
PHST- 2018/06/16 00:00 [accepted]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/08/22 06:00 [entrez]
PHST- 2018/08/21 00:00 [pmc-release]
AID - 000490952 [pii]
AID - iaa-0177-0192 [pii]
AID - 10.1159/000490952 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2018;177(3):192-198. doi: 10.1159/000490952. Epub 2018 
      Aug 21.