PMID- 30130792
OWN - NLM
STAT- MEDLINE
DCOM- 20181107
LR  - 20181107
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 177
IP  - 2
DP  - 2018
TI  - Association between Allergic Diseases and Irritable Bowel Syndrome: A 
      Retrospective Study.
PG  - 153-159
LID - 10.1159/000489611 [doi]
AB  - BACKGROUND: The relationship between allergic disease and irritable bowel 
      syndrome (IBS) is poorly understood. We aimed to investigate the potential 
      association as well as the underlying immunological mechanisms. METHODS: A 
      retrospective case-control study of 108 atopic patients from among outpatients in 
      an allergy clinic (allergic rhinitis [AR], n = 49; chronic urticaria [CU], n = 
      59) and 74 controls from among ward companions was conducted from November 2016 
      to March 2017. The detection rates and related gastrointestinal (GI) symptoms of 
      IBS, as well as immunological indices, were calculated. RESULTS: CU patients had 
      a trend of increase in the detection of IBS compared to controls (OR = 4.846; 95% 
      CI 0.967-24.279, p = 0.077). Loose stools (OR = 2.406; 95% CI 1.075-5.386, p < 
      0.05) and viscous stools (OR = 2.665; 95% CI 1.250-5.682, p < 0.05) were more 
      common in CU patients. Atopic patients positive for serum total immunoglobulin E 
      (IgE) (OR = 3.379; 95% CI 1.088-10.498, p < 0.05) or house dust mite 
      (HDM)-specific IgE (OR = 3.640; 95% CI 1.228-10.790, p < 0.05) were more likely 
      to have abdominal bloating. Besides, a positive association between levels of 
      total IgE and severity of abdominal bloating was observed (p < 0.05). An 
      HDM-specific IgE-positive reaction was independently associated with abdominal 
      bloating in atopic patients (p < 0.05). CONCLUSIONS: Allergic disease has a clear 
      clinical association with IBS with more frequent and severe symptoms of IBS. CU 
      patients have a tendency to suffer from IBS, usually with diarrhea. Serum total 
      IgE and HDM-specific IgE are positively correlated with GI symptoms in atopic 
      patients.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Fang, Zhi-Yun
AU  - Fang ZY
AD  - Department of Gastroenterology, The Second Affiliated Hospital, School of 
      Medicine, Jiaxing College, Jiaxing, China.
AD  - Department of Gastroenterology, The First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Zhang, Hong-Tao
AU  - Zhang HT
AD  - Department of Gastroenterology, The First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Lu, Chao
AU  - Lu C
AD  - Department of Gastroenterology, The First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Lu, Qi-Ming
AU  - Lu QM
AD  - Department of Gastroenterology, The Second Affiliated Hospital, School of 
      Medicine, Jiaxing College, Jiaxing, China.
FAU - Yu, Chao-Hui
AU  - Yu CH
AD  - Department of Gastroenterology, The First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Wang, Hui-Ying
AU  - Wang HY
AD  - Department of Allergy, The Second Affiliated Hospital, Zhejiang University School 
      of Medicine, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20180821
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Immunoglobulin E/*blood
MH  - Irritable Bowel Syndrome/*complications
MH  - Male
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Allergy
OT  - Gastrointestinal symptoms
OT  - Immune reaction
OT  - Irritable bowel syndrome
OT  - Rhinitis
OT  - Urticaria
EDAT- 2018/08/22 06:00
MHDA- 2018/11/08 06:00
CRDT- 2018/08/22 06:00
PHST- 2018/04/19 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/08/22 06:00 [pubmed]
PHST- 2018/11/08 06:00 [medline]
PHST- 2018/08/22 06:00 [entrez]
AID - 000489611 [pii]
AID - 10.1159/000489611 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2018;177(2):153-159. doi: 10.1159/000489611. Epub 2018 
      Aug 21.